Hydrochlorides
Medchemexpress LLC SHP2-IN-6 hydrochloride | 2169223-49-6 | 98.9% | 25 MG
JAB-3068 hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. It inhibits the proliferation of KYSE-520 cells with an IC50 of 2.17 μM. This product is intended for research use only and is not for sale to patients.
- Potent SHP2 inhibitor with an IC50 of 25.8 nM
- Inhibits KYSE-520 cell proliferation with an IC50 of 2.17 μM
- Extracted from patent WO2017211303A1, compound 7
- For research use only
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.9% | 1088.21 | 25 MG
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively, and induces apoptosis.
- Antagonist of inhibitor of apoptosis proteins (IAPs)
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells in cooperation with IFNγ or viral double-stranded RNA (dsRNA)
- Downregulates cIAP-1, activates RIPK1, and triggers activation of extrinsic and intrinsic apoptosis pathways in H1975 NSCLC cells
- Involves in apoptosis in HCC827 NSCLC cells due to induction of cell death and active caspase-3/8 activities by AZD5582 and IFNγ co-treatment
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in MDA-MB-231 xenograft-bearing mice
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 | 25 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist. It demonstrates high selectivity with EC50s of 0.028 μM for OX2R and 2.75 μM for OX1R. This compound has been shown to ameliorate narcolepsy-cataplexy symptoms in mouse models, increasing wakefulness and decreasing NREM sleep time.
- Selective orexin type-2 receptor (OX2R) agonist
- Nonpeptide compound
- EC50 of 0.028 μM for OX2R
- Ameliorates narcolepsy-cataplexy symptoms in mouse models
- Increases wakefulness
- Decreases NREM sleep time
eMolecules 246257-69-2 | DICYCLOPROPYLAMINE HYDROCHLORIDE | MFCD06796385 | 1g
Ambeed | Ethyl 7-amino-5-chloro-1H-indole-2-carboxylate | 100mg | 596569065 | A644870 | 59694-51-8 | MFCD20923225 | 238.670 | C11H11ClN2O2
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Sigma Aldrich Fine Chemicals Biosciences Alosetron hydrochloride >=98% (HPLC) | 122852-69-1 | MFCD09028027 | 10MG
Alosetron hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 330.81 | 122852-69-1 | MFCD09028027 | 10MG
Sigma Aldrich Fine Chemicals Biosciences 3-Pyridylacetic acid hydrochloride 98% | 6419-36-9 | MFCD00012819 | 25G
3-Pyridylacetic acid hydrochloride 98% | Purity: 98% | Mol Wt: 173.6 | 6419-36-9 | MFCD00012819 | 25G
Sigma Aldrich Fine Chemicals Biosciences 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | 23007-85-4 | MFCD00012790 | 10MG
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | Mol Wt: 209.72 | 23007-85-4 | MFCD00012790 | 10MG
Chem-Impex International, Inc. 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 10G
2-Iminothiolane hydrochloride, 4781-83-3, MFCD00039013, 10G
AdipoGen Terbinafine hydrochloride
Chemical. CAS 78628-80-5. Formula C21H25N . HCl. MW 291.4 . 36.5. Synthetic. Terbinafine is an antifungal and antimycotic compound that is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. It is clinically used to treat nail and skin infections. Inhibits ergosterol synthesis, essential component of fungal cell membranes. Potent non-competitive inhibitor at the stage of squalene epoxidation IC50=30nM for C. albicans. Selective activator of the K2P channel TASK3 pEC50 = 6.2. Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 pIC50 = 5.69. K2P channels might also be a target for ist antifungal activity. Shown to exhibit at higher concentrations anti-tumor and anti-angiogenic activity by inducing cell cycle arrest, and to display interesting anti-inflammatory and free radical scavenging activities.
Chem-Impex International, Inc. O-Benzyl-hydroxylamine hydrochloride | 2687-43-6 | MFCD00012952 | 250G
O-Benzyl-hydroxylamine hydrochloride, 2687-43-6, MFCD00012952, 250G
Med Vet International Terbinafine Hcl (Lamisil) 250mg Tablet White Round 30 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Terbinafine HCL (Lamisil) 250mg Tablet White Round 30 Tablets.
Medchemexpress LLC uPSEM792 hydrochloride | 2341841-08-3 | 99.9% | 277.75 g/mol | C14H16ClN3O | 10 MG
uPSEM792 hydrochloride is an ultrapotent pharmacologically selective effector molecule (uPSEM) that acts as a high-affinity agonist for engineered PSAM4-GlyR receptors. It is provided for research use only and is commonly used in neuroscience experiments to selectively activate PSAM4-based receptors.
- High potency agonist for PSAM4-GlyR with reported Ki ≈ 0.7 nM.
- Suitable for in vitro and in vivo research applications.
- Supplied as the hydrochloride salt with high chemical purity.
- Available in small research-scale quantities for experimental use.
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 99.9% | 591.23 | 25 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It is used as a tocolytic agent and shows less activity on VP receptors in human and rat liver and kidney.
- Potent, orally bioavailable, non-peptide oxytocin receptor antagonist
- IC50s of 8.9 nM for rat uterus oxytocin receptor
- IC50s of 26 nM for human uterus oxytocin receptor
- Used as a tocolytic agent
- Less active on VP receptor in human and rat liver and kidney
- Exhibits similar pharmacokinetics in rats and dogs
- Orally available with demonstrated bioavailability in rats
Apexbio Technology LLC RS 127445 199864-87-4 5mg
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity