Hydrochlorides
![Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242004.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 10 MG
VU 0255035 is a selective, competitive antagonist of the M1 muscarinic acetylcholine receptor used in preclinical research on central nervous system disorders. The compound (CAS 1135243-19-4) has molecular formula C18H20N6O3S2 and is supplied as a high-purity research-grade material for in vitro and in vivo pharmacology.
- Selective M1 receptor antagonism for pharmacological and mechanistic studies.
- High chemical purity suitable for analytical and biological assays.
- Available in multiple small-quantity formats for flexibility in dosing and screening.
- Suitable for both in vitro and in vivo experimental applications.
- Stable when stored under recommended conditions for research use.
Apexbio Technology LLC Dapoxetine HCl 129938-20-1 25mg
Dapoxetine hydrochloride (CAS 129938-20-1) is a short-acting selective serotonin reuptake inhibitor (SSRI) It exerts its pharmacological effect by inhibiting the reuptake of serotonin (5-HT) at the presynaptic membrane thereby increasing serotonin activity in the synaptic cleft This modulation of serotonergic neurotransmission has been shown to delay ejaculation latency making dapoxetine hydrochloride an established model compound for investigating serotonergic regulation of ejaculatory control It is widely used in research on the neurobiology and therapeutic approaches to premature ejaculation and related disorders
Apexbio Technology LLC Tirofiban hydrochloride monohydrate 150915-40-5 10mM (in 1mL DMSO)
Tirofiban hydrochloride monohydrate (CAS 150915-40-5) is a small-molecule inhibitor targeting platelet glycoprotein IIb/IIIa receptors It is designed to reversibly antagonize the binding of fibrinogen to these receptors thereby inhibiting platelet aggregation and thrombus formation Tirofiban hydrochloride monohydrate exerts its biological activity primarily through selective reversible inhibition of glycoprotein IIb/IIIa-mediated platelet aggregation Based on these pharmacological properties tirofiban hydrochloride monohydrate holds research potential in antithrombotic therapy and the investigation of unstable angina and thrombus-associated cardiovascular conditions
Abcam VU 0238429, allosteric M5 modulator, 5MG
MW 351.28 Da, Purity >99%. Selective, positive allosteric M5 modulator (EC50 values are 1.16 and >30 μM at M5 and M1/ M3 receptors, respectively). Shows no activity at M2 and M4 receptors.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Cyclopentanecarboxylic acid, 1-(4-nitrophenyl)-, 2-(diethylamino)ethyl ester, hydrochloride | 98636-73-8 | MFCD00673872 | 99.6% | 370.87 g/mol | C18H27ClN2O4 | 25 MG
Nitrocaramiphen hydrochloride is a selective M1 muscarinic receptor antagonist supplied as the hydrochloride salt for research use. It inhibits muscarine-induced hyperpolarization in muscle fibers and is provided as a white to off-white solid suitable for biochemical and pharmacological studies.
- Selective M1 receptor antagonist (Ki: 5.5 nM).
- High purity: 99.6% (manufacturer COA).
- White to off-white solid, molecular formula C18H27ClN2O4.
- Molecular weight 370.87 g/mol.
- Available in small milligram quantities for research use.
- Store sealed away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC LY-272015 hydrochloride | 172895-15-7 | 99.5% | 372.89 | C21H25ClN2O2 | 5 MG
LY-272015 hydrochloride is a research compound used as a selective 5-HT2B (serotonin) receptor antagonist for preclinical pharmacology studies. It is orally active in animal models and has been reported to show antihypertensive effects in DOCA-salt hypertensive rats. The material is supplied as a solid for laboratory use with supporting analytical documentation.
- Selective 5-HT2B receptor antagonist for target-specific studies.
- Orally active in preclinical models, useful for in vivo pharmacology.
- High purity suitable for research applications.
- Supplied as an off-white to light yellow solid for ease of handling.
- Provided with data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Iso-H7 dihydrochloride | 140663-38-3 | 99.1% | 364.29 | 50 MG
Iso-H7 dihydrochloride is an inhibitor of protein kinase with IC50 values of 22 and 34 μM to PKC and PKA respectively. It has negative control of PKA on satellite cell myogenesis. This product offers high purity and is suitable for various research applications.
- Inhibits protein kinase with IC50 values of 22 and 34 μM to PKC and PKA.
- Exhibits negative control of PKA on satellite cell myogenesis.
- Boasts a high purity of 99.06%.
- Has a molecular weight of 364.29.
- Presents as a white to off-white solid.
- Readily soluble in water and DMSO.
- Recommended shipping at room temperature and storage at 4°C.
Cayman Chemical Terbinafine hydrochloride
A broad-spectrum antifungal agent; has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml); selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively); induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and HUVECs from 90-120 μM
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 500 MG
Nilotinib hydrochloride dihydrate is the hydrochloride dihydrate salt of nilotinib (AMN107), an orally active Bcr-Abl tyrosine kinase inhibitor used in research on chronic myelogenous leukemia. Supplied as a solid powder for laboratory research, the material is provided with assay data and manufacturer storage guidance for short- and long-term handling.
- High purity (99.9%).
- Solid powder form suitable for research use.
- Molecular formula C28H27ClF3N7O3; molecular weight 602.01 g/mol.
- Available in multiple pack sizes, including 500 mg.
- Store sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Bestatin hydrochloride | 65391-42-6 | MFCD00058004 | 99.9% | 50 MG
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, primarily used for cancer research. This compound has demonstrated a range of biological activities both in vitro and in vivo.
- Enhances ATRA-induced differentiation
- Inhibits ATRA-driven phosphorylation of p38 MAPK in ATRA-sensitive APL NB4 cells
- Slowing cell cycle progression at 600 μM
- Inhibits mitosis and multinuclearity in D. discoideum
- Not cytotoxic at 0-600 μM
- Reduces CD13 expression in diabetic mice
- Inhibits MMP-9 specific gelationolytic band densities
- Downregulates HIF-1α and VEGF expression in diabetic mice retinas
- Increases splenocytes producing hemolytic anti-SRBC antibodies
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 50 MG
GW405833 (L768242) hydrochloride is a potent and selective cannabinoid receptor 2 (CB2) agonist, exhibiting high affinity for CB2 over CB1. It also functions as a non-competitive CB1 antagonist and can inhibit cAMP production stimulated by Forskolin. This compound notably inhibits glycolysis by down-regulating HIF-1α, suggesting its role in alleviating acute liver failure (ALF).
- Potent, selective cannabinoid receptor 2 (CB2) agonist.
- Exhibits non-competitive CB1 antagonist activity.
- Inhibits glycolysis by down-regulating HIF-1α.
- Alleviates acute liver failure (ALF).
- Reverses mechanical pain in neuropathic and inflammatory pain models.
Medchemexpress LLC Gr 55562 dihydrochloride | 159533-25-2 | 99.0% | 448.39 | C23H27Cl2N3O2 | 5 MG
GR 55562 dihydrochloride is a selective serotonin 5-HT1B and 5-HT1D receptor antagonist supplied as the dihydrochloride salt for research use. It is commonly used in receptor pharmacology and behavioral studies to probe serotonergic mechanisms in vitro and in vivo.
- Selective 5-HT1B/5-HT1D receptor antagonist.
- Suitable for in vivo and in vitro studies.
- High purity (99.0%).
- Provided as the dihydrochloride salt for improved solubility.
- Available in small quantities for research use (5 MG, 10 MG).
- Includes documentation: datasheet, COA, and SDS.
Chem-Impex International, Inc. O-Benzyl-hydroxylamine hydrochloride | 2687-43-6 | MFCD00012952 | 250G
O-Benzyl-hydroxylamine hydrochloride, 2687-43-6, MFCD00012952, 250G
Medchemexpress LLC 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 137.63 | C4H8ClNS | 100 MG
2-Iminothiolane hydrochloride is a thiolating reagent that converts primary amines into free sulfhydryl (-SH) groups for protein, peptide, and oligosaccharide modification. It reacts under mild conditions (pH 7-10) to form an amidine linkage while introducing a reactive thiol, enabling subsequent labeling, crosslinking, or conjugation for research applications.
- Introduces free sulfhydryl groups to primary amines.
- Reacts efficiently at neutral to slightly basic pH (7-10).
- Forms stable amidine linkages upon conjugation.
- Enables protein and peptide labeling and crosslinking.
- Suitable for bioconjugation and assay development.