Hydrochlorides
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 100 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of the TGF-β type I receptor kinase (ALK5) used for biochemical and cell-based studies. It potently inhibits ALK5 kinase activity and reduces Smad2/3 phosphorylation in cellular assays, making it suitable for research on TGF-β/Smad signaling and related applications.
- Potent ALK5 inhibition, IC50 = 2.72 nM.
- Cellular activity: inhibits Smad2/3 phosphorylation in A549 cells, IC50 = 8.68 nM.
- High reported purity (99.22%).
- Supplied as the hydrochloride salt; available in research pack sizes including 100 mg.
- Molecular weight 334.85 g·mol-1; formula C14H11ClN4S2.
![Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000308312.png-250.jpg)
Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG
TP0427736 hydrochloride is a research-grade small-molecule ALK5 (TGF-β receptor I) inhibitor supplied as the hydrochloride salt. The compound is provided as a high-purity solid intended for in vitro biochemical and cellular studies, with documented solubility in water and DMSO and recommended cold storage for long-term stability.
- High purity suitable for research assays.
- Hydrochloride salt form improves aqueous and DMSO solubility.
- Documented solubility values aid experimental planning.
- Stable when stored as powder at recommended cold temperatures.
- Appropriate for pathway, target validation, and pharmacology studies.
Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 500 UG
XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. It has an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
- Potent Kv7 (KCNQ) channels blocker.
- Inhibits Kv7.1, Kv7.2, Kv7.2 + Kv7.3 channels, and M-current.
- IC50s: 0.75 μM (Kv7.1), 0.71 μM (Kv7.2), 0.6 μM (Kv7.2 + Kv7.3), 0.98 μM (M-current).
- EC50 of 490 nM for enhancing [3H]ACh release from rat brain slices.
- Good in vivo potency and duration of action.
Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.86% | 534.48 | 25 MG
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor, showing slight selectivity over p38β and >1000-fold selectivity against p38γ and p38δ. It is also extremely potent in inhibiting whole blood LPS stimulated TNFα and inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Orally active and selective p38α inhibitor.
- Exhibits potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Modest selectivity against JNK2 (ki=39 nM) and JNK3 (ki=61 nM).
- Rat F of 62% and dog F of 47%.
- t1/2 is 4.6 hours in rats and 7.3 hours in dogs.
Medchemexpress LLC DRP1i27 dihydrochloride | 1453028-33-5 | C20H28Cl2N6O | 100 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1 (0-50 μM).
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Exhibits a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
Medchemexpress LLC Buformin hydrochloride | 1190-53-0 | 99.78% | 100 MG
Buformin hydrochloride is a potent AMPK activator and an orally active biguanide antidiabetic agent. It decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. It also exhibits anti-cancer activities and is used in cancer studies.
- Potent AMPK activator
- Orally active biguanide antidiabetic agent
- Decreases hepatic gluconeogenesis
- Lowers blood glucose production in vivo
- Exhibits anti-cancer activities
- Used in cancer studies including cervical cancer and breast cancer
Medchemexpress LLC Harmalol hydrochloride | 6028-07-5 | 100 MG
Harmalol hydrochloride is a beta carboline alkaloid primarily found in medicinal plants such as *Peganum harmala*. This compound serves as the main metabolite of Harmaline and has been shown to significantly inhibit the dioxin-mediated induction of CYP1A1 at both transcriptional and posttranslational levels. Furthermore, it exhibits notable antioxidant and hydroxyl radical-scavenging properties, making it of interest for various research applications.
- Main metabolite of Harmaline
- Inhibits dioxin-mediated induction of CYP1A1
- Exhibits antioxidant and hydroxyl radical-scavenging properties
- Suitable for research applications
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MG
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist. It demonstrates an IC50 of 32±3 nM in LLC-PK1 cells and a dissociation constant (Kb) of 19±6 nM. This compound does not induce intracellular calcium mobilization on its own.
- Antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a)
- IC50 of 32±3 nM in LLC-PK1 cells
- Dissociation constant (Kb) of 19±6 nM
- Does not induce intracellular calcium mobilization
- Attenuates phencyclidine (PCP)-induced deficits in prepulse inhibition in vivo
Selleck Chemical LLC VU 0357121 S2795-10mg
VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM is inactive or very weakly antagonizing at other mGlu receptor subtypes
FUJIFILM BIOSCIENCES INC 2 5-DIAMINOTOLUENE DIHYDROCHLO
*Orders for this supplier are non-cancellable/non-returnable once they are processed.* 2,5-Diaminotoluene Dihydrochloride 250GR
eMolecules 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | 98338-26-2 | MFCD16618478 | 1g
AstaTech | 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | 1g | 222806229 | 84194 | 95.000 | 98338-26-2 | MFCD16618478 | 273.012 | C7H15Br2N
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Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
![Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241984.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 | C18H20N6O3S2 | 100 MG
VU 0255035 is a selective and competitive M1 muscarinic acetylcholine receptor (M1 mAChR) antagonist used as a research tool to probe M1 signaling and neuronal excitability in central nervous system disease models.
- Selective, competitive M1 muscarinic receptor antagonist.
- Brain-penetrant compound suitable for CNS studies.
- High purity, approximately 99.8%.
- Molecular weight 432.52 g/mol; chemical formula C18H20N6O3S2.
- Appearance: solid, light yellow to brown; supplied as 100 MG quantities.
- Used in research related to epilepsy, Parkinson's disease, and dystonia.
Medchemexpress LLC Zt 52656a hydrochloride | 115730-24-0 | MFCD00673899 | 100.0% | 390.87 g/mol | C19H26ClF3N2O | 25 MG
ZT 52656A hydrochloride is a selective kappa-opioid receptor agonist supplied as the hydrochloride salt for preclinical and in vitro research, including studies of ocular pain. The compound is for research use only and is not intended for human therapeutic use.
- Selective kappa-opioid receptor agonist.
- Provided as the hydrochloride salt.
- High purity (99.98%).
- Molecular weight 390.87 g/mol.
- Chemical formula C19H26ClF3N2O.
- Appearance: solid, white to off-white.
- Available in small research sizes, e.g., 25 MG.
- Intended for preclinical and in vitro research use only.