Hydrochlorides
Apexbio Technology LLC RS 127445 HCl 199864-87-4 50mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC SB-399885 hydrochloride | 402713-81-9 | 98.3% | 482.81 g/mol | C18H22Cl3N3O4S | 100 MG
SB-399885 hydrochloride is a research-grade small molecule that functions as a selective 5-HT6 receptor antagonist for laboratory pharmacology and neuroscience studies. It is supplied as a solid reagent and should be handled and stored according to standard laboratory safety practices.
- Acts as a selective 5-HT6 receptor antagonist
- Suitable for in vitro and in vivo pharmacology studies
- Supplied as a solid with reported purity of 98.3%
- Molecular weight 482.81 g/mol; CAS 402713-81-9
- Available in multiple pack sizes for dose-ranging experiments
- For research use only; not for human or clinical use
Medchemexpress LLC Procaine hydrochloride | 51-05-8 | 99.75% | 50 MG
Procaine hydrochloride (Standard) is the analytical standard of Procaine (hydrochloride), intended for research and analytical applications. It acts as a DNA-demethylating agent with a slow onset and a short duration of action. This analytical standard is a reference standard supplied assay.
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC applications
- Suitable for GC applications
- Suitable for MS applications
Medchemexpress LLC Tyramine hydrochloride | 60-19-5 | MFCD00012901 | 99.8% | 173.64 g/mol | C8H12ClNO | 1 ML
Tyramine hydrochloride is the hydrochloride salt of tyramine, provided as a research-grade chemical for biochemical and analytical applications. It is supplied in high-purity solid and ready-to-use DMSO solution forms, with accompanying safety and technical documentation for laboratory use.
- High purity suitable for analytical and research applications.
- Available as powder or pre-made DMSO solution for convenience.
- Supplied with product data sheet and safety data sheet for handling guidance.
- Commonly used as an analytical standard and biochemical reagent.
- Molecular weight and formula provided for accurate calculations.
Medchemexpress LLC Fipexide hydrochloride | 34161-23-4 | 99.9% | 50 MG
Fipexide hydrochloride is a parachloro-phenossiacetic acid derivative and an orally active nootropic agent. It reduces striatal adenylate cyclase activity and positively affects cognitive performance through dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. It also acts as a chemical inducer in callus formation, shoot regeneration, and Agrobacterium infection.
- Reduces striatal adenylate cyclase activity.
- Positively affects cognitive performance.
- Used in senile dementia research.
- Acts as a chemical inducer in callus formation, shoot regeneration, and Agrobacterium infection.
- Abolishes memory deficits produced by kindling.
Medchemexpress LLC FFN 206 dihydrochloride | 1883548-88-6 | 99.5% | 291.17 | 25 MG
FFN 206 dihydrochloride is a fluorescent probe utilized as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. It can detect VMAT2 activity in intact cells using fluorescence microscopy, localizing to VMAT2-expressing acidic compartments without apparent labeling of other organelles. This probe is for research use only and not sold to patients.
- Detects VMAT2 activity in intact cells
- Subcellular localization to VMAT2-expressing acidic compartments
Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 10 MG
XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker. It potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. This compound is designed for research applications.
- Potent Kv7 (KCNQ) channels blocker
- Inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current
- Enhances [3H]ACh release from rat brain slices with an EC50 of 490 nM
- Demonstrates good in vivo potency and duration of action
- For research use only
Apexbio Technology LLC Duloxetine HCl 136434-34-9 10mM (in 1mL DMSO)
Duloxetine hydrochloride (CAS 136434-34-9) is a small molecule compound classified as a selective inhibitor of serotonin and norepinephrine reuptake By blocking the reabsorption of these neurotransmitters at the synaptic cleft duloxetine modulates serotonergic and noradrenergic signaling within the central nervous system This pharmacological action has rendered it a valuable tool in research models investigating neurochemical pathways involved in mood regulation pain perception and stress response Duloxetine HCl is commonly utilized in studies of depression anxiety and chronic pain to elucidate monoaminergic mechanisms and to evaluate therapeutic strategies targeting neurotransmitter reuptake
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 100.0% | 591.23 | 10 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It has IC50s of 8.9 nM for rat uterus oxytocin receptor and 26 nM for human uterus oxytocin receptor. It is used as a tocolytic agent.
- Potent oxytocin receptor antagonist
- Selective action
- Orally bioavailable
- Non-peptide structure
- IC50s of 8.9 nM for rat uterus oxytocin receptor and 26 nM for human uterus oxytocin receptor
- Used as a tocolytic agent
- Soluble in DMSO (100 mg/mL)
- Soluble in H2O (5 mg/mL)
- Storage at 4°C sealed, away from moisture
- In solvent storage at -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC Itopride hydrochloride | 122892-31-3 | 99.8% | 5 G
Itopride hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. It enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, making it a gastrointestinal prokinetic agent. It can be used for researching gastro-esophageal reflux disease (GERD).
- Potent dopamine-2 antagonist
- Acetylcholine esterase (AChE) inhibitor
- Enhances gastric motility
- Acts as a gastrointestinal prokinetic agent
- Used for researching gastro-esophageal reflux disease (GERD)
- Shows prokinetic effects on ileum and colon by inhibiting AChE and antagonizing dopamine D2 receptor
- Accelerates gastric emptying
Medchemexpress LLC Prazosin hydrochloride | 19237-84-4 | 99.89% | 500 MG
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist, primarily used for research into high blood pressure and alcohol use disorders. It potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM, and also inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM, respectively.
- CNS-active α1-adrenergic receptor antagonist
- Potently inhibits norepinephrine (NE)-stimulated 45Ca efflux
- Inhibits organic cation transporters OCT-1 and OCT-3
- Inhibits proliferation, migration, and invasion of U251 and U87 cells, and promotes apoptosis via the PI3K/AKT/mTOR signaling pathway
- Peripheral administration can suppress central α1-adrenergic-mediated hyperexcitability and stress-induced anxiety
Medchemexpress LLC ZM323881 (hydrochloride) | 193000-39-4 | 99.6% | 411.86 | 10 MG
ZM323881 (hydrochloride) | 193000-39-4 | 99.6% | 411.86 | 10 MG
Medchemexpress LLC Doxepin impurity 1 (hydrochloride) | 4504-96-5 | 25mg
Doxepin impurity 1 hydrochloride is an impurity of Doxepin (HY-B0725A)
Medchemexpress LLC Zm323881 (hydrochloride) | 193000-39-4 | C22H19ClFN3O2 | 50 MG
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. It is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity, demonstrating excellent selectivity versus other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGFR2 tyrosine phosphorylation, making it suitable for research applications.
- Potent and selective VEGFR2 inhibitor
- Anilinoquinazoline structure
- Inhibits VEGF-A-induced endothelial cell proliferation
- Inhibits VEGFR2 tyrosine phosphorylation
- For research use only
Medchemexpress LLC Dptn dihydrochloride | 325767-87-1 | 98.5% | 459.39 g/mol | C22H20Cl2N4OS | 10 MG
DPTN dihydrochloride is a research-grade dihydrochloride salt that functions as a potent, selective antagonist of the adenosine A3 receptor (A3AR) in human, mouse, and rat. It is supplied as a solid for in vitro and receptor-binding studies and is intended for research use only.
- Potent A3AR antagonist with high affinity (hA3 Ki = 1.65 nM; mouse = 9.61 nM; rat = 8.53 nM).
- High purity suitable for biochemical assays (98.47%).
- Solid, light yellow to yellow physical form for easy handling.
- Soluble in DMSO (~5 mg/mL) with ultrasonic warming recommended.
- Stable when stored sealed at -20°C; in solution store at -80°C for long-term.