Hydrochlorides
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 1 ML
Azaphen dihydrochloride monohydrate, also known as Pipofezine, is a potent inhibitor of serotonin reuptake. This tricyclic antidepressant (TCA) is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Tricyclic antidepressant for depression treatment
- Available as a 10 mM solution in water
- High purity for reliable research applications
Apexbio Technology LLC Doxepin (hydrochloride) 1229-29-4 10mM (in 1mL DMSO)
Doxepin (hydrochloride) (CAS 1229-29-4) is a tricyclic antidepressant that functions as a potent antagonist of the histamine H1 receptor a G protein coupled receptor expressed in tissues such as smooth muscle vascular endothelium cardiac tissue and the central nervous system In vitro doxepin acts as a competitive inhibitor of serotonin uptake in human platelets with a reported Ki of approximately 0 2 M and can induce rapid serotonin efflux at higher concentrations In vivo studies in rodents and canines demonstrate efficient oral absorption and metabolic conversion in liver and urine with central nervous system penetration observed in rats Doxepin is widely used in research related to neurotransmitter modulation and histaminergic signaling
Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 1 ML
Duloxetine, also known as LY248686, is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. It is utilized in the treatment of major depressive disorder and generalized anxiety disorder. This product is supplied as a 10mM solution in 1mL of DMSO, with a high purity of 99.92%.
- Serotonin-norepinephrine reuptake inhibitor (SNRI)
- Inhibits reuptake with a Ki of 4.6 nM
- Used for treating major depressive disorder
- Applied in generalized anxiety disorder treatment
- High purity for research applications
- Supplied as a convenient 10mM solution in DMSO
- Recommended storage in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | MFCD00933882 | 99.5% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, a selective, orally active 5-HT2B receptor antagonist. It blocks 5-HT or BW723C86-induced ERK2 phosphorylation and has demonstrated antihypertensive activity in DOCA-salt hypertensive rat models. Supplied as a high-purity off-white to light-yellow solid for research use.
- Selective 5-HT2B receptor antagonist.
- Orally active compound suitable for in vivo studies.
- Inhibits 5-HT or BW723C86-induced ERK2 phosphorylation.
- Demonstrated antihypertensive effects in DOCA-salt hypertensive rats.
- High reported purity (99.5%).
- Soluble in DMSO at 5 mg/mL with ultrasonic assistance.
![Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244527.png-250.jpg)
Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.
- Selective positive allosteric modulation of mAChR M5.
- EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
- Enhances acetylcholine-stimulated insulin secretion in human β-cells.
- Available as solid or as a 10 mM solution in DMSO for flexible application.
- High purity suitable for biochemical and cellular assays.
Medchemexpress LLC N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide monohydrochloride | 402713-81-9 | >98.0% | 482.8 g·mol⁻¹ | C18H21Cl2N3O4S · HCl | 25 MG
SB-399885 hydrochloride is a research compound that acts as a selective antagonist of the serotonin 5-HT6 receptor (CAS 402713-81-9). It is used in vitro and in vivo to study 5-HT6-mediated signaling and cognitive effects, and is supplied as the monohydrochloride salt to improve solubility for biological assays.
- 5-HT6 receptor antagonist activity for receptor pharmacology studies.
- Reported high purity for reliable experimental results.
- Monohydrochloride salt form improves solubility in aqueous media.
- Suitable for in vitro and in vivo neuroscience applications.
- Supplied in small research pack sizes for dose-response and pilot studies.
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.77% | 360.33 | 25 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It shows >50-fold selectivity over other CDK kinases and exhibits potent anti-tumor activity.
- Potent and selective CDK9 inhibitor.
- Orally active.
- Exhibits >50-fold selectivity over other CDK kinases.
- Possesses potent anti-tumor activity.
- Reduces downstream phosphorylation of RNA Pol II.
- Downregulates global androgen receptor (AR) protein levels.
- Decreases nascent transcription and depletes short half-life transcripts.
- Well tolerated and significantly reduces tumor burden in xenograft models.