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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Purity 99.63%
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VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC50 of 46±10 nM. It is a sterically demanding molecule that significantly inhibits PTEN activity in low nanomolar concentrations. It is considered an encouragingly specific and potent PTEN inhibitor and is the most potent inhibitor (IC50=35 nM) of the PTEN lipid phosphatase activity.
Potent PTEN inhibitor
IC50 of 46±10 nM
Significantly inhibits PTEN activity in low nanomolar concentrations
Considered specific and potent
Most potent inhibitor of PTEN lipid phosphatase activity
Used in research
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Vardenafil HCl Trihydrate (CAS 330808-88-3) is the trihydrate salt form of vardenafil a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) In enzymatic assays vardenafil demonstrates an IC50 of 0 7 nM for PDE5 exhibiting high selectivity over other phosphodiesterase isoforms with significantly higher IC50 values for PDE1 PDE2 PDE3 PDE4 and PDE6 Vardenafil enhances relaxation of human trabecular smooth muscle in response to sodium nitroprusside acetylcholine and electrical stimulation and increases cGMP concentrations in human corpus cavernosum tissue These properties establish its utility in studies addressing cGMP-mediated smooth muscle relaxation and PDE5-related pharmacology
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RNase L-IN-1 trihydrochloride is the trihydrochloride salt form of a small-molecule inhibitor of RNase L, supplied for research use to study RNase L-mediated RNA degradation, antiviral responses, and inflammation. The compound is provided as a solid salt suitable for biochemical and cellular assays.
Inhibits RNase L activity for mechanistic and antiviral research.
Trihydrochloride salt form improves solubility and handling.
High purity (~98.1%) suitable for research applications.
Yellow to brown solid appearance, powder form for storage.
Molecular formula C27H35FN6O3S; molecular weight 542.67 g/mol.
Store powder at -20°C for long-term stability; follow supplier guidelines.
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Peramivir Trihydrate (BCX-1812 RWJ-270201 S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent specific influenza viral neuraminidase inhibitor with an IC50 of median 0 09 nM
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Alendronate sodium trihydrate (G-704650 MK-217) a nitrogen-containing bisphosphonate is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis
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Irinotecan HCl Trihydrate (CAS 136572-09-3) also known as CPT-11 is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity It acts as a soluble prodrug which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38 a potent inhibitor of topoisomerase I CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3 4 M and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies
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