Dimethyl Sulfoxide
Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 10mM (in 1mL DMSO)
Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
Apexbio Technology LLC Carfilzomib (PR-171) 868540-17-4 10mM (in 1mL DMSO)
Carfilzomib (PR-171 CAS 868540-17-4) is a derivative of the natural product epoxomicin and functions as an irreversible inhibitor of the chymotrypsin-like activity within the 20S proteasome Proteasomes play a critical role in intracellular protein degradation thus inhibition results in accumulation of polyubiquitinated proteins Through this mechanism Carfilzomib induces cell cycle arrest and apoptosis consequently suppressing tumor cell growth Research applications primarily involve exploration of its antitumor efficacy and mechanisms in oncology models
Apexbio Technology LLC MLN4924 905579-51-3 10mM (in 1mL DMSO)
MLN4924 (CAS 905579-51-3) is a selective inhibitor targeting NEDD8-activating enzyme (NAE) exhibiting an IC50 of 4 nM It acts competitively against AMP binding within the nucleotide-binding pocket of NAE with strong specificity over related enzymes UAE SAE UBA6 and ATG7 (IC50 1 5 M) In HCT-116 cells MLN4924 reduces Ubc12-NEDD8 and cullin-NEDD8 conjugation disrupting CRL-mediated ubiquitination and thus stabilizing substrates such as CDT1 resulting in cell cycle defects MLN4924 shows antitumor efficacy in HCT-116 H522 and Calu-6 tumor xenograft models highlighting its research utility in cancer biology
Apexbio Technology LLC Org 27569 868273-06-7 10mM (in 1mL DMSO)
Org 27569 (CAS 868273-06-7) is an allosteric modulator targeting the cannabinoid CB1 receptor It enhances the binding of the agonist CP55940 to purified CB1 receptors while simultaneously inhibiting receptor functionality In electrically-stimulated mouse vas deferens assays Org 27569 reduced WIN55212-induced contractions exhibiting a pEC50 of 8 24 0 12 and a maximal response (Emax) of approximately 45 4% Binding studies suggest its interaction at a putative allosteric site on CB1 receptors reflected by parameters such as a pKB of 5 67 0 23 and a Log of 1 14 0 17 Org 27569 serves as a tool compound for studying CB1 receptor allosteric modulation
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 | C2H6OS | 100mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 10mM (in 1mL DMSO)
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Pomalidomide (CC-4047) 19171-19-8 10mM (in 1mL DMSO)
Pomalidomide (CC-4047) an immunomodulatory derivative structurally related to Thalidomide exhibits anti-tumor and anti-angiogenic properties Chemically the molecule is distinguished by additional amino substituent at the fourth position of the phthalimide ring and two extra oxy groups Its mechanism of action includes modulation of specific cytokines within the tumor microenvironment (TNF- IL-6 IL-8 VEGF) suppression of tumor cell proliferation and modification of host immune cell activity Pomalidomide is widely studied in biomedical research particularly in therapeutic exploration for hematologic malignancies such as multiple myeloma including relapsed or refractory disease states
Apexbio Technology LLC Resveratrol 501-36-0 10mM (in 1mL DMSO)
Resveratrol is a naturally occurring polyphenolic phytoalexin known to function as an activator of the NAD-dependent protein deacetylase SIRT1 Through SIRT1 activation resveratrol modulates downstream pathways implicated in cellular metabolism inflammation aging and tumorigenesis Commonly employed in biomedical research settings resveratrol serves as a molecular tool to explore the regulatory roles and signaling mechanisms involving sirtuin-mediated pathways Cellular assays have demonstrated resveratrol s inhibitory activity against multiple targets with reported IC50 values typically ranging from 20 to 50 M depending on cell type and experimental conditions Therefore resveratrol is widely utilized in vitro and in vivo to elucidate its roles in metabolic regulation inflammation responses cardiovascular function and cancer biology
Apexbio Technology LLC Sulfamethazine 57-68-1 10mM (in 1mL DMSO)
Sulfamethazine (Sulfadimidine) is a sulfonamide antimicrobial agent that exerts antibacterial activity by competitively inhibiting bacterial dihydropteroate synthase an enzyme crucial for the synthesis of folic acid in bacteria Through this enzyme inhibition sulfamethazine disrupts bacterial folate metabolism impairing bacterial DNA and protein synthesis pathways In biomedical research this compound is commonly employed as an investigative tool for studying bacterial infections particularly in animal models representing respiratory and gastrointestinal infections attributed to susceptible bacterial strains In vitro studies report IC50 values for bacterial dihydropteroate synthase inhibition typically ranging from 5 to 50 M depending on experimental conditions and bacterial species tested Additionally sulfamethazine serves as a reference compound in research examining antimicrobial resistance and pharmacokinetic parameters
Apexbio Technology LLC D4476 301836-43-1 10mM (in 1mL DMSO)
D4476 (CAS 301836-43-1) is a selective cell-permeable inhibitor of casein kinase 1 (CK1) and ALK5 exhibiting IC50 values of 0 3 M for CK1 and 0 5 M for ALK5 (at 0 1 mM ATP in vitro) It likely acts via ATP-competitive inhibition of CK1 showing minimal to no significant inhibitory activity against SAPK2a/p38 PKB or SGK Treatment with D4476 inhibits CK1-mediated phosphorylation of FOXO1a (Ser322 and Ser325) and RhoB (Ser185) in H4IIE and HeLa cells respectively impacting downstream processes such as nuclear export dynamics and actin cytoskeleton regulation Additionally it induces partial p53-dependent growth arrest in HCT116 cells
Apexbio Technology LLC Gliclazide 21187-98-4 10mM (in 1mL DMSO)
Gliclazide (CAS 21187-98-4) is an oral hypoglycemic agent classified structurally as a sulfonylurea derivative It exerts its biological effects primarily by targeting pancreatic beta-cell sulfonylurea receptors (SUR1) stimulating insulin secretion through the closure of ATP-dependent potassium channels This channel inhibition induces cellular depolarization facilitating calcium influx and subsequent insulin exocytosis In a research context gliclazide is utilized extensively as a pharmacological tool to study pancreatic beta-cell function insulin secretion dynamics and diabetic pathophysiology
Apexbio Technology LLC Ambrisentan 177036-94-1 10mM (in 1mL DMSO)
Ambrisentan (CAS 177036-94-1) is an orally active selective endothelin receptor antagonist specifically targeting ETA receptors It exhibits strong selectivity towards ETA over ETB receptor subtypes shown by Ki values of approximately 1 nM for recombinant ETA receptors expressed in vitro versus 195 nM for ETB In recombinant human receptor assays using intact cells this selectivity is enhanced with reported Ki values of 0 63 nM (ETA) and 48 7 nM (ETB) Pharmacologically ambrisentan s selective ETA blockade preserves the ETB receptor s intrinsic vasodilatory and endothelin clearance functions making it useful in research involving pulmonary arterial hypertension cerebrovascular conditions and ischemia-reperfusion injury