Dimethyl Sulfoxide
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC Go 6983(Synonyms: GO-6983, GO6983, PKC Inhibitor GO 6983, Pan-PKC Inhibitor GO-6983, PKC inhibitor GO6983, 133053-19-7), 10mM (in 1mL DMSO), CAS: 133053-19-7.
Go 6983 (CAS 133053-19-7) is a selective inhibitor of protein kinase C isoforms PKC PKC PKC PKC and PKC with reported IC50 values of approximately 7 nM 7 nM 6 nM 10 nM and 20 mM respectively Protein kinase C (PKC) isoforms act as receptors for tumor-promoting phorbol ester mediating various downstream cellular functions In cancer cell models Go 6983 suppresses PKC and PKC activation induced by phorbol esters and reduces PKC expression inhibiting cell survival pathways It is frequently employed in biomedical studies examining PKC-dependent signaling in cancer progression and epithelial-to-mesenchymal transition (EMT)
Apexbio Technology LLC VX-661(Synonyms: Tezacaftor, VX661, VX-661, VX 661), 10mM (in 1mL DMSO), CAS: 1152311-62-0.
VX-661 (CAS 1152311-62-0) is a small-molecule CFTR corrector developed by Vertex Pharmaceuticals designed to restore trafficking and enhance cellular surface expression of the mutated F508del-CFTR protein By facilitating proper folding and transport of this commonly mutated cystic fibrosis transmembrane conductance regulator (CFTR) VX-661 increases CFTR-mediated chloride channel activity in vitro Preclinical and clinical research have explored VX-661 alone and in combination with ivacaftor demonstrating enhanced F508del-CFTR functionality and providing a promising strategy for addressing cystic fibrosis caused by the F508del mutation
Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mM (in 1mL DMSO), CAS: 755038-02-9.
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
AdipoGen DAF-4T Solution 5 mM in DMSO
Chemical. CAS 212558-80-0. Formula C20H7Cl2N3O5. MW 440.19. Fluorescent reference compound for DAF-4 DA CDX-D0216. Spectral data lambdaEx=505nm lambdaEm=530nm.
Apexbio Technology LLC BI6727 (Volasertib)(Synonyms: Volasertib, BI-6727, BI 6727, Plk inhibitor BI6727, Polo-like kinase inhibitor BI6727), 10mM (in 1mL DMSO), CAS: 755038-65-4.
BI6727 (Volasertib CAS 755038-65-4) is a selective inhibitor of Polo-like kinases (Plk) primarily targeting Plk1 with an IC50 of 0 87 nM and showing lower potency towards Plk2 (IC50 5 nM) and Plk3 (IC50 56 nM) Plk1 regulates the G2/M cell cycle transition and is commonly overexpressed in various tumor types representing a potential therapeutic target BI6727 inhibits proliferation across multiple tumor cell lines including colorectal (HCT116 EC50 23 nM) lung (NCI-H460 EC50 21 nM) melanoma (BRO EC50 11 nM) and hematologic cancer (GRANTA EC50 15 nM) In vivo BI6727 administration induced apoptosis and reduced tumor growth in mouse HCT116 and NCI-H460 xenograft models
Apexbio Technology LLC Fluoxetine HCl(Synonyms: Prozac, Sarafem, Fluoxetine Hydrochloride, Lilly 110140, Fluoxeren, Fluctin), 10mM (in 1mL DMSO), CAS: 56296-78-7.
Fluoxetine HCl (CAS 56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks presynaptic serotonin (5-HT) transporters resulting in elevated extracellular serotonin levels It modulates serotonergic signaling through inhibition of serotonin-induced membrane currents in cloned 5HT2C receptors exhibiting an IC50 around 20 M and binds 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM) Fluoxetine treatment has been shown in vivo to stimulate neurogenesis and enhance neuronal maturation and synaptic plasticity within rat hippocampus and prefrontal cortex Widely employed in neuroscience research fluoxetine aids in studies of depression stress resilience and neuro-regulatory mechanisms involving serotonergic signaling
U.S. Pharmacopeia Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 3g
Molecular formula C2H6OS, Molecular weight 78.13, Melting Point 64.4 - 66.2 °F (18 - 19 °C), Boiling Point 372.2 °F (189 °C), Synonyms: DMSO, Methyl sulfoxide
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 18L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 18L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5 | MFCD00002089 | 5vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 5vl
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 4X4L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4X4L
Medchemexpress LLC Dimethyl sulfoxide (GMP like) | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 100mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 5X10ML
NC3592570 DIMETHYL SULFOXIDE 5X10ML
Medchemexpress LLC Nvp-Dky709 Soltn 10Mm 1Ml Dmso | HY-144998-10MM 1ML DMSO
Nvp-Dky709 Soltn 10Mm 1Ml Dmso