Dimethyl Sulfoxide
Apexbio Technology LLC MLN4924 905579-51-3 10mM (in 1mL DMSO)
MLN4924 (CAS 905579-51-3) is a selective inhibitor targeting NEDD8-activating enzyme (NAE) exhibiting an IC50 of 4 nM It acts competitively against AMP binding within the nucleotide-binding pocket of NAE with strong specificity over related enzymes UAE SAE UBA6 and ATG7 (IC50 1 5 M) In HCT-116 cells MLN4924 reduces Ubc12-NEDD8 and cullin-NEDD8 conjugation disrupting CRL-mediated ubiquitination and thus stabilizing substrates such as CDT1 resulting in cell cycle defects MLN4924 shows antitumor efficacy in HCT-116 H522 and Calu-6 tumor xenograft models highlighting its research utility in cancer biology
Apexbio Technology LLC PF-670462 950912-80-8 10mM (in 1mL DMSO)
PF-670462 (CAS 950912-80-8) is a selective inhibitor of casein kinase 1 (CK1) isoforms CK1 and CK1 serine/threonine kinases involved in circadian rhythm regulation It exhibits inhibitory activity toward CK1 and CK1 with IC50 values of approximately 80 nM and 13 nM respectively In cellular models co-transfected with GFP-tagged PER3 and human CK1 PF-670462 blocks nuclear translocation of PER3 In primary fibroblasts from wild-type mice it dose-dependently prolongs circadian cycle length PF-670462 serves as a useful chemical tool for studying CK1-mediated modulation of circadian rhythms
Apexbio Technology LLC Olaparib (AZD2281, Ku-0059436) 763113-22-0 10mM (in 1mL DMSO)
Olaparib (AZD2281 Ku-0059436 CAS 763113-22-0) is a selective inhibitor of poly(ADP-ribose) polymerase-1 and -2 (PARP-1/2) By targeting PARP enzymes involved in DNA repair Olaparib specifically inhibits the proliferation of BRCA-deficient tumor cell lines and enhances radiosensitivity in experimental tumor models In xenograft mouse models of non-small cell lung carcinoma (NSCLC) Olaparib has been shown to elevate radiation sensitivity and improve tumor perfusion The compound is widely utilized in studies focused on DNA damage responses tumor radiosensitization and targeted therapy strategies for BRCA-associated cancers
Apexbio Technology LLC Calcitriol 32222-06-3 10mM (in 1mL DMSO)
Calcitriol the biologically active metabolite of vitamin D3 functions primarily through interaction with the intracellular vitamin D receptor (VDR) regulating transcription of genes involved in mineral homeostasis and immune responses It modulates cellular differentiation proliferation and adaptive immune functions via nuclear receptor-mediated mechanisms In vitro studies demonstrate that calcitriol dose-dependently inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF- ) and interleukin-1 (IL-1 ) secretion from human peripheral blood mononuclear cells (PBMCs) Additionally animal models indicate that calcitriol administration decreases cytokine release associated with inflammatory stimuli through intracellular calcium-dependent signaling pathways Calcitriol is widely utilized in biomedical research concerning osteometabolic regulation immune modulation and cytokine signaling networks
Apexbio Technology LLC CVT-313 199986-75-9 10mM (in 1mL DMSO)
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Sigma Aldrich Fine Chemicals Biosciences Cell freezing Medium-DMSO
Cell freezing medium is a combination of cryoprotectant DMSO with fetal bovine serum. However serum free medium replaces serum with methylcellulose and poloxamer 188 and other additives like ascorbic acid tocopherol and proline.
Apexbio Technology LLC PF-4708671 1255517-76-0 10mM (in 1mL DMSO)
PF-4708671 (CAS 1255517-76-0) is a cell-permeable small molecule that specifically inhibits p70 ribosomal S6 kinase 1 (S6K1) S6K1 regulates diverse cellular processes including protein synthesis and insulin signaling pathways PF-4708671 inhibits S6K1 with an IC50 of 160 nM in HEK293 cell-derived enzyme assays and has a reported Ki value of 20 nM in vitro It selectively inhibits S6K1 over structurally related kinases such as RSK2 and MSK1 hindering phosphorylation of downstream substrates including ribosomal protein S6 mTOR and Rictor PF-4708671 is valuable in biomedical research involving cancer and insulin resistance
Apexbio Technology LLC BX795 702675-74-9 10mM (in 1mL DMSO)
BX795 (CAS 702675-74-9) is a small-molecule inhibitor targeting 3-phosphoinositide-dependent kinase-1 (PDK1) through ATP-competitive binding inhibiting its enzymatic activity with an IC50 of approximately 11 nM Additionally BX795 selectively inhibits TBK1 and IKK with reported IC50 values of 6 nM and 41 nM respectively In macrophages activated by poly(I C) and LPS BX795 suppresses TBK1/IKK -mediated interferon regulatory factor-3 (IRF3) phosphorylation nuclear translocation transcriptional activity and consequent interferon- production This compound is utilized in biomedical research examining kinase signaling pathways and innate immune responses
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Electron Microscopy Sciences (DMSO), Dimethyl Sulfoxide, Reagent A.C.S. 450 ML
(2-Hydroxyethyl methacrylate monomer, inhibited;HEMA)
CAS #67-68-5 (CH₃)₂SO F.W. 78.13