Tetrahydrofuran
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Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 50 MG
AVJ16 is an inhibitor of insulin-like growth factor 2 mRNA binding protein (IGF2BP1), which shows a strong affinity with a Kd of 1.4 μM. It acts as a cancer cell migration inhibitor by interfering with IGF2BP1's ability to bind target mRNA, thereby regulating gene expression and translation.
- Specifically targets IGF2BP1 with a Kd of 1.4 μM.
- Interferes with IGF2BP1 binding to target mRNA, regulating gene expression and translation.
- Inhibits proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth, and induces apoptosis in H1299 and LKR-M-FI cells.
- Exhibits antitumor activity in xenograft mouse models.
