Tetrahydrofuran
Medchemexpress LLC Rhodojaponin III | 26342-66-5 | 5 MG
Rhodojaponin III is a diterpenoid extracted from the leaves of Rhododendron molle. It exhibits anti-inflammatory activity, demonstrated by its IC50 of 7 μM against LPS-induced nitric oxide production in mouse RAW264.7 cells. This compound has a molecular weight of 368.46 and a chemical formula of C20H32O6. It typically appears as a white to off-white solid.
- Extracted from the leaves of Rhododendron molle
- Exhibits anti-inflammatory activity
- Has an IC50 of 7 μM against LPS-induced nitric oxide production in mouse RAW264.7 cells
- Molecular weight is 368.46
- Chemical formula is C20H32O6
- Appears as a white to off-white solid
- Intended for research use only
Medchemexpress LLC Deacylmetaplexigenin | 3513-04-0 | 1 MG
Deacylmetaplexigenin is a natural product and steroid, specifically a pregnane glycoside. This compound has been isolated from plants such as Asclepias incarnata, Cynanchum viminale, and Cynanchum rostellatum.
- Molecular weight: 380.5 g/mol
- XLogP3-AA: -0.4
- Hydrogen bond donors: 5
- Hydrogen bond acceptors: 6
- Rotatable bond: 1
- Topological polar surface area: 118 Ų
Medchemexpress LLC Zectivimod | 1623066-63-6 | 99.4% | 528.47 | 100 MG
Zectivimod is a sphingosine-1-phosphate receptor agonist. It is intended for research applications related to autoimmune diseases, chronic inflammatory diseases, and immunoregulation disorders.
- Sphingosine-1-phosphate receptor agonist
- Suitable for research on autoimmune diseases
- Suitable for research on chronic inflammatory diseases
- Suitable for research on immunoregulation disorders
- Solid appearance, white to off-white color
- Purity of 99.35%
- Store at 4°C, sealed, away from moisture and light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light
- Target LPL receptor
- Part of the GPCR/G protein pathway
- Solubility in DMSO: 100 mg/mL
Medchemexpress LLC Phosphatidylinositols, soya, sodium salts | 383907-36-6 | 99.2% | 1 MG
Phosphatidylinositols, soya, sodium salts, is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They function by recruiting and/or activating effector proteins.
- Involved in regulating various cellular functions
- Regulates vesicular budding
- Regulates membrane fusion
- Regulates cytoskeleton dynamics
Medchemexpress LLC Ecliptasaponin D | 206756-04-9 | 5 MG
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba (L.) Hassk, which is the aerial part of Eclipta prostrate. Eclipta prostrate is considered a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory properties.
- Triterpenoid glucoside
- Isolated from Eclipta alba (L.) Hassk
- Anti-inflammatory properties
- Hepatoprotective properties
- Antioxidant properties
- Immunomodulatory properties
Medchemexpress LLC PhosTAC7 | 3016307-75-5 | 99.23% | C58H87ClN2O17 | 50 MG
PhosTAC7 is a heterobifunctional molecule, also known as a Phosphorylation Targeting Chimera (PhosTAC). It is designed to dephosphorylate specific proteins by recruiting serine/threonine protein phosphatase 2A (PP2A), making it a valuable tool for various research applications.
- Selectively modulates the phosphorylation state of individual target proteins.
- Dephosphorylates PDCD4, FOXO3a, and tau proteins.
- Useful in research for cancer.
- Applicable in the study of tau protein-related neurodegenerative diseases, such as Alzheimer's.
- For research use only.
Medchemexpress LLC TMX-4100 | 2367619-63-2 | 98.2% | C11H10N4O2S | 100 MG
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. It demonstrates a high degradation preference for PDE6D with DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. This compound can be utilized for research into multiple myeloma.
- Demonstrates a high degradation preference for PDE6D in MOLT4 cells.
- Exhibits better proteome-wide degradation selectivity in MOLT4 cells.
- Does not hinder the growth of KRAS-dependent cell lines.
Medchemexpress LLC N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide | 2922283-38-1 | 98.0% | C93H177N3O3 | 50 MG
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3, an ionizable lipid-like material used for mRNA delivery. It presents as an oil, with a color ranging from off-white to light yellow.
- Analogue of TT3
- Ionizable lipid-like material
- Used for mRNA delivery
- Appears as an oil
- Off-white to light yellow color
Medchemexpress LLC SR8278 | 1254944-66-5 | 99.9% | C18H19NO3S2 | 50 MG
SR8278 is a REV-ERBα antagonist that inhibits the transcriptional repression activity of REV-ERBα with an EC50 of 0.47 μM. It is utilized to regulate metabolism in organisms, study biological rhythms, and research Duchenne muscular dystrophy and Alzheimer's disease.
- Inhibits REV-ERBα transcriptional repression activity (EC50 of 0.47 μM)
- Regulates metabolism and biological rhythm
- Supports research on Duchenne muscular dystrophy
- Supports research on Alzheimer's disease
- Exerts antidepressant and anxiolytic effects
- Restores circadian rhythm of mood-related behaviors
- Alters REV-ERBα and NURR1 binding activities
Medchemexpress LLC PD-1/PD-L1-IN-23 | 2597056-04-5 | 99.9% | C32H30BrCl2N3O6 | 50 MG
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. It is an ester proagent of L7, a benzo[c]oxadiazole derivative biologically evaluated as an inhibitor of PD-L1. It has shown significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice.
- Potent and orally active inhibitor of PD-1/PD-L1
- Ester proagent of L7, a benzo[c]oxadiazole derivative
- Displays significant antitumor effects in tumor models
- For research use only
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 100 MG
AVJ16 is a cancer cell migration inhibitor targeting the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with an affinity (Kd) of 1.4 μM. It interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation, inhibiting proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells. It also suppresses colony formation and spheroid growth, induces apoptosis in certain cell lines, and demonstrates antitumor activity in xenograft mouse models.
- Targets IGF2BP1, a key protein in cancer cell migration.
- Interferes with mRNA binding to regulate gene expression.
- Inhibits proliferation, invasion, and migration of lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth.
- Induces apoptosis in relevant cell lines.
- Shows antitumor activity in xenograft mouse models.
Medchemexpress LLC AST5902 trimesylate | 2929417-90-1 | 98.8% | 842.88 | 50 MG
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. It exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
- Principal metabolite of Alflutinib
- Exerts antineoplastic activity
- EGFR inhibitor
- Yellow to orange solid
- Store at 4°C, sealed, away from moisture and light
- In solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Su 5214 | 186611-04-1 | MFCD01595259 | >98.0% | 10 MG
SU5214 is a small-molecule tyrosine kinase inhibitor reported to inhibit vascular endothelial growth factor receptor 2 (VEGFR2/FLK-1) and epidermal growth factor receptor (EGFR) in cell-free assays. It is used for biochemical studies and target validation involving VEGFR2/EGFR signaling pathways.
- Reported IC50 of 14.8 μM for VEGFR2 (cell-free assay).
- Reported IC50 of 36.7 μM for EGFR (cell-free assay).
- CAS number 186611-04-1.
- Molecular weight 251.285 g·mol⁻¹.
- Purity greater than 98% (HPLC) as supplied by chemical vendors.
- Supplied in small milligram quantities suitable for in vitro assays.
![Medchemexpress LLC N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide] | 368449-04-1 | 98.6% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232665.png-250.jpg)
Medchemexpress LLC N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide] | 368449-04-1 | 98.6% | 50 MG
MST-312 (Telomerase Inhibitor IX) is a small-molecule telomerase inhibitor derived from epigallocatechin gallate (EGCG). It is supplied as a white to off-white solid for laboratory research in oncology and telomerase studies.
- Telomerase inhibitor for cancer research.
- Chemically modified derivative of epigallocatechin gallate (EGCG).
- Molecular formula C20H16N2O6 and molecular weight 380.35 g·mol⁻1.
- Purity 98.6%.
- Supplied as a solid with common solubility in DMSO for solution preparation.
Medchemexpress LLC PF-00446687 free base | 862281-92-3 | 98.0% | 470.59 g/mol | C28H36F2N2O2 | 50 MG
PF-00446687 free base is a non-peptide, brain-penetrant small-molecule agonist of the melanocortin-4 receptor (MC4R) used in research on melanocortin signaling and central nervous system pharmacology. It is supplied as a powder for in vitro and in vivo studies and demonstrates low-nanomolar potency and selectivity.
- Selective melanocortin-4 receptor agonist with EC50 12 ± 1 nM.
- Binding affinity (Ki) approximately 27 ± 4 nM.
- Brain-penetrant, suitable for central nervous system studies.
- Provided as a powder with solubility in DMSO 62.5 mg/mL (ultrasonic recommended).
- Molecular formula C28H36F2N2O2 and molecular weight 470.59 g/mol.
- High purity by HPLC (≈98.0% per COA).
- Storage: powder -20°C (long-term) or 4°C (short-term).