Tetrahydrofuran
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 100 MG
AVJ16 is a cancer cell migration inhibitor targeting the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with an affinity (Kd) of 1.4 μM. It interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation, inhibiting proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells. It also suppresses colony formation and spheroid growth, induces apoptosis in certain cell lines, and demonstrates antitumor activity in xenograft mouse models.
- Targets IGF2BP1, a key protein in cancer cell migration.
- Interferes with mRNA binding to regulate gene expression.
- Inhibits proliferation, invasion, and migration of lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth.
- Induces apoptosis in relevant cell lines.
- Shows antitumor activity in xenograft mouse models.
Medchemexpress LLC Broflanilide (Standard) | 1207727-04-5 | 98% | 663.28 | 50 MG
Broflanilide (Standard) | 1207727-04-5 | 98% | 663.28 | 50 MG
Medchemexpress LLC VPC-70619 | 2361742-30-3 | 99.93% | C16H8ClF3N4O | 100 MG
VPC-70619 is a potent N-Myc inhibitor that blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box and shows strong inhibitory activity against N-Myc-dependent cell lines. It can partially reverse paclitaxel resistance in cells by reducing MYCN expression and can be used for cancer research, including neuroblastoma and thyroid cancer.
- Potent N-Myc inhibitor
- Blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box
- Shows strong inhibitory activity against N-Myc-dependent cell lines
- Partially reverses paclitaxel resistance by reducing MYCN expression
- Can be used for cancer research, including neuroblastoma and thyroid cancer
- Demonstrates high inhibition rates in certain cell types
- Highly stable in liver microsomes
- Regulates MYCN signaling pathway
- Inhibits proliferation, migration, and aggressiveness of cancer cells
Medchemexpress LLC Rhodojaponin III | 26342-66-5 | 5 MG
Rhodojaponin III is a diterpenoid extracted from the leaves of Rhododendron molle. It exhibits anti-inflammatory activity, demonstrated by its IC50 of 7 μM against LPS-induced nitric oxide production in mouse RAW264.7 cells. This compound has a molecular weight of 368.46 and a chemical formula of C20H32O6. It typically appears as a white to off-white solid.
- Extracted from the leaves of Rhododendron molle
- Exhibits anti-inflammatory activity
- Has an IC50 of 7 μM against LPS-induced nitric oxide production in mouse RAW264.7 cells
- Molecular weight is 368.46
- Chemical formula is C20H32O6
- Appears as a white to off-white solid
- Intended for research use only
Medchemexpress LLC N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide | 2922283-38-1 | 98.0% | C93H177N3O3 | 50 MG
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3, an ionizable lipid-like material used for mRNA delivery. It presents as an oil, with a color ranging from off-white to light yellow.
- Analogue of TT3
- Ionizable lipid-like material
- Used for mRNA delivery
- Appears as an oil
- Off-white to light yellow color
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 50 MG
AVJ16 is an inhibitor of insulin-like growth factor 2 mRNA binding protein (IGF2BP1), which shows a strong affinity with a Kd of 1.4 μM. It acts as a cancer cell migration inhibitor by interfering with IGF2BP1's ability to bind target mRNA, thereby regulating gene expression and translation.
- Specifically targets IGF2BP1 with a Kd of 1.4 μM.
- Interferes with IGF2BP1 binding to target mRNA, regulating gene expression and translation.
- Inhibits proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth, and induces apoptosis in H1299 and LKR-M-FI cells.
- Exhibits antitumor activity in xenograft mouse models.
Medchemexpress LLC Deacylmetaplexigenin | 3513-04-0 | 1 MG
Deacylmetaplexigenin is a natural product and steroid, specifically a pregnane glycoside. This compound has been isolated from plants such as Asclepias incarnata, Cynanchum viminale, and Cynanchum rostellatum.
- Molecular weight: 380.5 g/mol
- XLogP3-AA: -0.4
- Hydrogen bond donors: 5
- Hydrogen bond acceptors: 6
- Rotatable bond: 1
- Topological polar surface area: 118 Ų
Medchemexpress LLC CIL62 | 117593-36-9 | 97.0% | 382.45 | 100 MG
CIL62 is a caspase-3/7-independent cell death inducer. Its mechanism of action is Necrostatin-1 dependent cell death.
- COLO 205: IC50 28 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- IMR-32: IC50 41 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- K562: IC50 36 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- Necrostatin-1 suppresses CIL62 at 19 μM (5 μg/mL).
Medchemexpress LLC ABD957 | 3007772-60-0 | 98.1% | C27H36F3N7O5S | 50 MG
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases. This compound can block N-Ras signaling and inhibit the growth of NRAS-mutant AML cells. It is intended for research use only.
- Potent and selective covalent inhibitor of ABHD17 family depalmitoylases
- Blocks N-Ras signaling
- Inhibits the growth of NRAS-mutant AML cells (OCI-AML3, THP1, HL60)
- Attenuates N-Ras depalmitoylation in AML cells at 500 nM
- Has an IC50 of 0.21 μM for ABHD17B
Medchemexpress LLC Onjisaponin B | 35906-36-6 | 99.1% | 10 MG
Onjisaponin B is a natural triterpenoid saponin isolated from Polygala tenuifolia with reported neuroprotective and autophagy-enhancing activity. It is used in cell-based and preclinical studies investigating protein aggregation, neurodegeneration, and inflammatory signaling.
- Natural triterpenoid saponin derived from Polygala tenuifolia.
- Inhibits NF-κB p65 and modulates inflammatory signaling.
- Enhances autophagy and promotes degradation of mutant α-synuclein and huntingtin.
- High purity solid powder (99.1%).
- Supplied as a 10 mg quantity suitable for research-scale assays.
- Intended for mechanistic studies and preclinical pharmacology models.
Medchemexpress LLC 9,19-Cyclolanostan-3-ol, 24-methylene-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate, (3β)- | 469-36-3 | 5 MG
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. It promotes parvin-beta expression in human breast cancer cells and is a potential ATP-competitive Akt1 inhibitor.
- Purity of 98.53%
- White to off-white solid appearance
- Soluble in DMSO at ≥ 12.5 mg/mL
- Classified as a terpenoid and phenol
- Derived from plants
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | 109-99-9 | MFCD00005356 | 4X4L
Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | Purity: >=99.9% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 4X4L
Medchemexpress LLC Su 5214 | 186611-04-1 | MFCD01595259 | >98.0% | 10 MG
SU5214 is a small-molecule tyrosine kinase inhibitor reported to inhibit vascular endothelial growth factor receptor 2 (VEGFR2/FLK-1) and epidermal growth factor receptor (EGFR) in cell-free assays. It is used for biochemical studies and target validation involving VEGFR2/EGFR signaling pathways.
- Reported IC50 of 14.8 μM for VEGFR2 (cell-free assay).
- Reported IC50 of 36.7 μM for EGFR (cell-free assay).
- CAS number 186611-04-1.
- Molecular weight 251.285 g·mol⁻¹.
- Purity greater than 98% (HPLC) as supplied by chemical vendors.
- Supplied in small milligram quantities suitable for in vitro assays.
Medchemexpress LLC Rhamnocitrin | 569-92-6 | MFCD00006839 | 300.26 | 1 MG
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3, and MAPK pathways. It selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons, and is applicable for studying endothelial-related inflammatory diseases and neuroprotection.
- Scavenges DPPH (IC50=28.38 mM).
- Up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE).
- Blocks NFATc3 nuclear translocation and downstream inflammatory factor expression.
- Induces heme oxygenase HO-1 expression and regulates the ERK/p38 MAPK pathway.
- Inhibits antioxidant and pro-inflammatory cytokines (e.g., IL-6, IL-8) and adhesion molecules (e.g., ICAM-1, VCAM-1).