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Synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate; includes the carotenoids, which are precursors of vitamin A and also possess antioxidant effects.
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rel-Bedaquiline is a drug impurity related to the anti-tuberculosis agent bedaquiline and is supplied as an analytical reference for research use only. It is intended for chromatographic and analytical method development, impurity profiling, and stability studies. Consult the Certificate of Analysis for batch-specific purity and storage conditions.
Intended for research use only; not for human or clinical use.
Impurity standard for analytical and chromatographic method development.
High purity reference: 97.56% by HPLC (batch dependent).
Suitable for impurity profiling and stability studies.
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Vitamin K1 is a naturally occurring vitamin essential for blood coagulation and bone and vascular metabolism. It is a prenylated naphthoquinone synthesized by plants, green algae, and some cyanobacteria, acting as an electron carrier in photosystem I.
Required for blood coagulation and bone and vascular metabolism in humans
Shows significant antiproliferative effects and induces apoptosis in Caco-2, HT-29, and SW480 cell lines
Increased dietary intake is associated with a reduced risk of incident diabetes
Supplementation reverses high-fat diet-induced bone deterioration
Topical application suppresses pigmentation and resolves bruising, promoting wound repair
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Vitamin K4 is a chemically synthesized Vitamin K that plays an important role in the normal blood coagulation system. It arrests cells in the S phase of the cell cycle and induces apoptosis, and can be used for research on cancer, including prostate cancer and osteosarcoma.
Inhibits cell proliferation and induces caspase-dependent apoptosis in PC-3 cells.
Induces S phase cell cycle arrest in PC-3 and U2OS cells.
Inhibits the growth of U2OS cells.
Increases ROS generation and disrupts mitochondrial membrane potential in U2OS cells.
Inhibits the migration of U2OS cells in vitro.
Modulates expression of Bcl-2, Bax, PARP, and cleaved-caspase-3.
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(±)-α-Tocopherol acetate, also known as (±)-Vitamin E acetate, is an orally active synthetic form of vitamin E. It is an ester of acetic acid and α-tocopherol. This compound is used for research into the susceptibility of farmed fish to infectious diseases.
Orally active synthetic form of vitamin E.
Can be used for research of the susceptibility of farmed fish to infectious diseases.
Exhibits significantly high complement activity when administered orally to gilthead seabream at specific dosages (600 mg/kg, 1200 mg/kg, 1800 mg/kg) over durations of 15, 30, and 45 days.
Stimulates the seabream's non-specific immune system after 30 days of dietary administration at 1200 mg/kg.
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Orbofiban acetate is an orally active platelet GPIIb/IIIa (integrin) antagonist that inhibits platelet aggregation and is supplied for research use to study platelet function and antithrombotic mechanisms.
Oral GPIIb/IIIa antagonist that inhibits platelet aggregation.
Used in platelet function and antithrombotic research.
Available as a solid and as a 10 mM solution in DMSO.
Molecular weight 361.4 g/mol.
High purity (about 98.1% by HPLC).
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GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that blocks the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). This compound enhances free thrombin generation and has demonstrated significant therapeutic potential in animal models, alleviating DSS-induced colitis by improving body weight loss and mortality.
L-NMMA acetate (CAS 53308-83-1) is a broad-spectrum inhibitor of nitric oxide synthases (NOS) exerting inhibitory effects on neuronal (nNOS) endothelial (eNOS) and inducible (iNOS) isoforms It demonstrates submicromolar to low micromolar inhibitory activity against rat nNOS human eNOS and mouse iNOS By selectively blocking NOS-mediated nitric oxide production L-NMMA acetate is widely utilized for dissecting nitric oxide-dependent signaling pathways with research applications spanning studies of tissue injury inflammatory responses and cardiovascular system functions
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rel-ACPT-I is a selective agonist of group III metabotropic glutamate receptors (mGluRs) with reported neuroprotective, anticonvulsant, and anxiolytic-like effects in preclinical studies. It is supplied as a high-purity research chemical for in vitro and in vivo pharmacology applications.
Selective agonist of group III metabotropic glutamate receptors.
Exhibits neuroprotective, anticonvulsant, and anxiolytic-like effects in preclinical models.
High purity (≥99.0%), suitable for pharmacological studies.
CAS number 194918-76-8 for unambiguous identification.
Molecular weight 217.18 g·mol⁻¹; formula C8H11NO6.
Soluble in water (~2 mg/mL) with sonication and warming.
Recommended storage: -20°C dry; solutions at -80°C (long term) or -20°C (short term).
Available in small research quantities, facilitating dose-response and in vivo dosing.
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S961 acetate is a high-affinity and selective insulin receptor (IR) antagonist. It exhibits IC50s of 0.048 nM for HIR-A, 0.027 nM for HIR-B, and 630 nM for human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay. It also shows high-affinity to Rat IR and Pig IR in PEG-assay.
High-affinity and selective insulin receptor antagonist
Exhibits high affinity for human, rat, and pig IR
Solid, white to off-white appearance
Soluble in DMSO and water
Stable under recommended storage conditions
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Also available in 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 uM exhibits > 200-fold selectivity over other HDAC. purity: 99%
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Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases thereby affecting several transcription factors including c-myc and c-fos. This agent inhibits tumor cell growth by inducing apoptosis and cell cycle arrest. purity: 99%
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