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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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Aryl Hydrocarbon Receptor Antibody (YA610) is a rabbit-derived, non-conjugated IgG monoclonal antibody. It targets the Aryl Hydrocarbon Receptor and is protein A affinity purified. This antibody is for research use only.
Rabbit-derived
IgG monoclonal antibody
Targets Aryl Hydrocarbon Receptor
Protein A affinity purified
Non-conjugated
Reactive with human samples
Suitable for Western Blot (WB) and Immunocytochemistry/Immunofluorescence (ICC/IF) applications
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Sodium 2-bromoethanesulfonate is an organosulfonate reagent supplied as a 10 mM solution in DMSO for biochemical and life-science research. The compound has CAS 4263-52-9, formula C2H4BrNaO3S, and a molecular weight of 211.01 g·mol⁻¹. The solid is described as white to off-white; listed purity is 97.0% (assay 99.7%). Certificates and safety data are available.
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RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively.
Orally active TRPV4 antagonist.
Excellent selectivity for related TRP receptors (TRPV1, TRPV3, TRPM8).
TRPV4 probe for focus screens.
IC50s: 0.26 μM for hTRPV4, 0.39 μM for rTRPV4.
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(7S)-BAY-593 is the S-enantiomer of BAY-593, an orally active GGTase-I inhibitor. It effectively blocks YAP1/TAZ signaling in animals and demonstrates significant antitumor activity.
S-enantiomer of BAY-593
Orally active GGTase-I inhibitor
Blocks YAP1/TAZ signaling
Exhibits antitumor activity
Targets YAP/TAZ-TEAD and GGTase I
Soluble in DMSO
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tCFA15 is a trimethyl cyclohexenonic long-chain fatty alcohol (C24H44O2, MW 364.60) that promotes neuronal differentiation and modulates Notch1 signaling. It is supplied as a high-purity research standard intended for in vitro studies of neural stem cell differentiation and neuronal signaling pathways.
Promotes differentiation of neural stem cell-derived neurospheres toward neurons.
Modulates Notch1 expression and signaling.
High purity suitable for in vitro research applications.
Soluble in DMSO for solution-based assays.
Shown to stimulate arginine vasopressin secretion in neurohypophysis preparations.
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Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. It has potential for treating major depressive disorder and is currently in phase II clinical development as an adjunctive therapy for this condition. Studies have shown that Rapastinel Trifluoroacetate produces an antidepressant-like effect and an anxiolytic effect in animal models, without altering locomotor activity.
NMDA receptor modulator with glycine-site partial agonist properties
Potential for treating major depressive disorder
Phase II clinical development as an adjunctive therapy
Produces antidepressant-like and anxiolytic effects in animal models
Does not alter locomotor activity
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CCL4 Protein Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface promotes leukocyte aggregation under various inflammatory conditions and contributes to immune protection against human immunodeficiency virus type 1 CCL4 Protein Human is a recombinant human CCL4 (A24-N92) expressed by E coli[1]
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CHI-KAT8i5 is a selective and orally active KAT8 inhibitor that induces cancer cell apoptosis and suppresses esophageal squamous cell carcinoma (ESCC) growth by targeting the KAT8/c-Myc signaling pathway. It is a white to off-white solid.
Selective KAT8 inhibitor
Induces cancer cell apoptosis
Suppresses ESCC tumor growth
Soluble in DMSO at 100 mg/mL
Stable as powder for up to 3 years
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1-Bromooctane is a primary alkyl bromide (CAS 111-83-1) commonly used as an electrophile in nucleophilic substitution and alkylation reactions. It functions as a building block in organic synthesis and is supplied for laboratory research applications.
Primary alkyl bromide suitable for SN2 reactions.
Useful electrophile for alkylation and substitution steps.
High purity for reliable reaction outcomes.
Available in multiple pack sizes for bench-scale synthesis.
Liquid at room temperature for easy handling and dosing.
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CHI-KAT8i5 is a selective, orally active KAT8 inhibitor that induces cancer cell apoptosis and suppresses esophageal squamous cell carcinoma (ESCC) growth by targeting the KAT8/c-Myc signaling pathway. It demonstrates high specificity and anti-proliferative effects in vitro and in vivo.
Selective, orally active KAT8 inhibitor
High specificity; does not bind to other HAT family proteins
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