HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increases food intake.
- Selective MC4 receptor antagonist
- Increases food intake
- Molecular weight: 1380.52
- Formula: C60H80F3N19O12S2
- Appearance: Solid
- Color: White to off-white
- Sequence shortening: Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (disulfide bridge: Cys1-Cys9)
- Solubility (in vitro): H2O : 50 mg/mL (36.22 mM; need ultrasonic)