Organic acids and derivatives
Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Inhibits SDMA and cell proliferation in MTAP-del cells
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
- Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
- Favorable ADME profile with high bioavailability and moderate to high clearance
Selleck Chemical LLC Orphenadrine Citrate S2054-50mg
Orphenadrine Citrate is a skeletal muscle relaxant it acts in the central nervous system to produce its muscle relaxant effects
Medchemexpress LLC ARL67156 trisodium hydrate | MFCD12910436 | 99.9% | 834.61 g/mol | C15H23Br2N5Na3O13P3 | 1 MG
ARL67156 trisodium hydrate is the trisodium salt hydrate form of ARL67156 (FPL 67156), a small-molecule inhibitor of ecto-ATPases used in research to study extracellular ATP signaling and disease models such as calcific aortic valve disease and asthma.
- Inhibits ecto-ATPase enzymes, including NTPDase1 (CD39), NTPDase3, and NPP1.
- Reported Ki values: 11 μM, 18 μM, and 12 μM for NTPDase1, NTPDase3, and NPP1, respectively.
- Purity 99.94% as reported on the product page.
- Supplied as a trisodium hydrate salt.
- Available in small research quantities (for example, 1 mg and 5 mg sizes).
Accela Chembio Inc Triethyl Methanetricarboxylate | 25g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
Triethyl Methanetricarboxylate | 25g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
TARGETMOL CHEMICALS INC Zoledronic acid monohydrate
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. Purity ≥95%
Medchemexpress LLC Pacritinib (citrate) | 1228923-42-9 | 99.7% | 664.70 | 1 ML
Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). This compound can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
- Potent inhibitor of wild-type JAK2 (IC50=23 nM)
- Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
- Inhibits FLT3 (IC50=22 nM)
- Inhibits FLT3D835Y mutant (IC50=6 nM)
- Used for research in acute myeloid leukemia (AML) and myelofibrosis (MF)
Alkali Scientific L (+) Rhamnose, Monohydrate, 500 G
L (+) Rhamnose Monohydrate is a high-purity sugar used in laboratory applications, especially in studies of bacterial metabolism and plant biology. This 500-gram supply is ideal for experiments requiring a consistent and reliable source of rhamnose. It is commonly used in biochemical assays, microbiological testing, and as a substrate in fermentation processes. The monohydrate form ensures accurate and reproducible results in laboratory experiments. Rhamnose is used in research on plant cell wall metabolism, microbial growth studies, and other applications where precise sugar control is critical. This bulk quantity is perfect for continuous research and experimental work.
Medchemexpress LLC 2-methylcitric acid trisodium | 117041-96-0 | MFCD16875437 | 96.0% | 272.10 g·mol⁻1 | C7H7Na3O7 | 5 MG
2-Methylcitric acid trisodium is the trisodium salt of 2-methylcitric acid provided as a white to off-white solid for laboratory research. It is an endogenous metabolite used as a marker in methylmalonic and propionic acidemias and is employed in biochemical and mitochondrial studies, where it has been reported to inhibit ADP-stimulated mitochondrial respiration supported by glutamate.
- Trisodium salt, white to off-white solid.
- CAS number 117041-96-0.
- Purity 96.0%.
- Molecular weight 272.10 g·mol⁻1; formula C7H7Na3O7.
- Highly soluble in water (100 mg/mL; may require ultrasonication).
- Storage: sealed at 4°C; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC cGAMP diammonium | 96.6% | 708.47 | 50 MG
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Endogenous second messenger in metazoans.
- Triggers interferon production in response to cytosolic DNA.
- Activates stimulator of interferon genes (STING).
- Activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Promotes the antigen-specific proliferation capacity of spleen cells in mice.
- Directly activates murine and human dendritic cells *in vitro*.
Apexbio Technology LLC Clomiphene citrate 50-41-9 10mM (in 1mL DMSO)
Clomiphene citrate (CAS 50-41-9) is a small-molecule modulator targeting estrogen receptors (ER) It is designed to selectively modulate ER-mediated signaling thereby influencing estrogen-dependent cellular pathways Clomiphene citrate exerts its biological activity primarily through competitive inhibition at estrogen receptors It demonstrates both antiestrogenic and estrogenic activities depending on tissue context Based on these pharmacological properties clomiphene citrate holds research potential in the investigation of estrogen receptor-mediated transcriptional regulation cellular proliferation and differentiation as well as hypothalamic-pituitary-gonadal axis regulation and ovarian follicular maturation in reproductive biology studies
eMolecules 29949-81-3 | Tris(4-bromophenyl)phosphane | MFCD02690473 | 250mg
Ambeed | (S)-2-Amino-3-(7-chloro-1H-indol-3-yl)propanoic acid | 100mg | 525092784 | A175659 | 73945-46-7 | MFCD09264322 | 238.670 | C11H11ClN2O2
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Teknova 20mM Sodium Citrate, 8% Sucrose, pH 6.0. 500mL, Endotoxin Tested, Sterile. 8 pack.
20mM Sodium Citrate, 8% Sucrose, pH 6.0. 500mL, Endotoxin Tested, Sterile. 8 pack.
Medchemexpress LLC Boc-NH-PEG1-CH2COOH | 142929-49-5 | 98.0% | C9H17NO5 | 1 G
Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Molecular weight: 219.23
- Appearance: Solid-liquid mixture
- Color: Colorless to light yellow
- SMILES: O=C(O)COCCNC(OC(C)(C)C)=O
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Solubility (in vitro): DMSO at 100 mg/mL (456.14 mM)
- Solubility (in vivo): Protocols available for DMSO, PEG300, Tween-80, Saline, SBE-β-CD, and Corn Oil
Medchemexpress LLC Bromo-PEG1-CH2COOH | 1135131-50-8 | >=97.0% | 100 MG
Bromo-PEG1-CH2COOH is a PROTAC linker, designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand.
- Used as a PROTAC linker
- Designed for PROTAC synthesis
- Contains two ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets a protein
- Exploits the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- For research use only
Medchemexpress LLC 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester | 544450-68-2 | 99.94% | 337.82 | 100 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM) that suppresses alcohol and chocolate self-administration in rats. Its effects are exerted through a composite mechanism, involving positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Exerts effects through a composite mechanism.
- Involves positive allosteric modulation of the GABAB receptor.
- Acts at the cannabinoid CB1 receptor.
- Has shown cytotoxicity against mouse NIH/3T3 cells with an IC50 of 59 μM.
- Relevant to research in neurological, eye or ear disease, neurodegenerative disease, depression, Alzheimer's disease, and Parkinson's disease.