Organonitrogen Compounds
Selleck Chemical LLC WM-3835-5mg
WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
Medchemexpress LLC N-Nitrosomorpholine | 59-89-2 | 100.0% | 1 ML
N-Nitrosomorpholine is a photosensitive nitrosamine that is carcinogenic and can be used to construct animal cancer models. It is for research use only and not sold to patients. High doses of N-Nitrosomorpholine can cause significant cytoplasmic and nuclear changes in livers, leading to toxic damage, single-cell necrosis, loss of glycogen, and induction of giant cell production, bile duct proliferation, and fibrosis. Cirrhosis becomes obvious by the 4th week of treatment, worsening by weeks 15-20, and leading to metastatic liver cancer and death in animals by weeks 30-40.
- Photosensitive nitrosamine
- Carcinogenic agent
- Used for animal cancer model construction
- For research use only
- Induces liver toxicity and cellular changes
- Causes necrosis and fibrosis in liver tissue
- Can lead to metastatic liver cancer and mortality in animals
Medchemexpress LLC N-Nitroso-N-methylurea | 684-93-5 | 103.08 | 5 G
N-Nitroso-N-methylurea is a potent carcinogen, mutagen, and teratogen. It functions as a direct-acting alkylating agent, interacting with DNA, and is known to target multiple animal organs, potentially leading to various cancers or degenerative diseases. This compound also serves as a precursor in the synthesis of diazomethane. It is a flammable solid intended for laboratory use in the manufacture of substances and is stable under recommended storage conditions.
- Functions as a direct-acting alkylating agent
- Interacts with DNA
- Targets multiple animal organs
- Leads to various cancers and/or degenerative diseases
- Precursor in the synthesis of diazomethane
- Used in animal modeling to construct tumor models
Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 50 MG
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates exquisite selectivity over related kinases, including AURKA/B and PLK1. It disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. It shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Selective and orally active PLK4 inhibitor.
- IC50 of 3 nM for PLK4.
- Exquisite selectivity over AURKA/B and PLK1.
- Disrupts centriole biogenesis in cancer cells.
- Leads to accumulation of PLK4 and p21 protein.
- Increased sensitivity in TRIM37-high-expressing cells or tumors.
- Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
Medchemexpress LLC Ciprofloxacin hydrochloride monohydrate | 86393-32-0 | 99.7% | 5 G
Ciprofloxacin hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. It induces mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. It also exhibits anti-proliferative activity and induces apoptosis. This compound is a fluoroquinolone antibiotic with potent antibacterial activity. This product is for research use only.
- Potent, orally active topoisomerase IV inhibitor
- Induces mitochondrial DNA and nuclear DNA damage
- Leads to mitochondrial dysfunction and ROS production
- Exhibits anti-proliferative activity
- Induces apoptosis
- Fluoroquinolone antibiotic with potent antibacterial activity
- Inhibits cell proliferation and causes cell cycle arrest at G2/M phase in tendon cells
- Shows potent activity against Y. pestis and B. anthracis
Medchemexpress LLC Der p 23 protein, Dermatophagoides pteronyssinus | >95.0% | 100 UG
Der p 23 is a recombinant major allergen from the house dust mite Dermatophagoides pteronyssinus, expressed in HEK293 cells and supplied as a lyophilized C-terminal His-tagged protein. It is >95% pure by reducing SDS-PAGE, has an approximate molecular weight of 19 kDa, and endotoxin <1 EU/μg. The product is formulated in PBS (pH 7.4) and is recommended to be stored at -20°C; add carrier protein for long-term storage.
- Recombinant protein expressed in HEK293 cells.
- C-terminal His tag for purification and detection.
- High purity (>95%) suitable for immunological assays.
- Low endotoxin level (<1 EU/μg) for sensitive applications.
- Lyophilized formulation; PBS-based, recommended -20°C storage.
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 5 MG
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.8% | 514.55 | 25 MG
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates high selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Selective and orally active PLK4 inhibitor.
- IC50 of 3 nM for PLK4.
- Exhibits exquisite selectivity over related kinases such as AURKA/B and PLK1.
- Disrupts centriole biogenesis in cancer cells.
- Leads to accumulation of PLK4 and p21 protein.
- Demonstrates increased sensitivity in TRIM37-high-expressing cells or tumors.
- Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Appearance: Solid, White to off-white.
Medchemexpress LLC Decamethonium Bromide | 541-22-0 | MFCD00011779 | 98.7% | 1 ML
Decamethonium Bromide is an acetylcholine receptor inhibitor and muscle relaxant. It functions by inducing depolarization of skeletal muscles and subsequently binding to postsynaptic acetylcholine receptors, leading to persistent paralysis. For research use only.
- Acetylcholine receptor inhibitor
- Muscle relaxant
- Induces depolarization of skeletal muscles
- Binds to postsynaptic acetylcholine receptors to induce persistent paralysis
Apexbio Technology LLC Guanidine HCl 50-01-1 10g
Guanidine hydrochloride (Guanidine HCl CAS 50-01-1) is a highly alkaline crystalline compound derived from the oxidative metabolism of guanine Functioning primarily as a strong chaotropic agent it disrupts hydrogen bonding and secondary structure in proteins leading to efficient protein denaturation and solubilization Widely utilized in molecular biology and biochemistry Guanidine HCl facilitates protein unfolding for downstream applications such as protein purification refolding studies and RNA extraction protocols where it also serves to inactivate nucleases and other enzymes
Apexbio Technology LLC Guanidine HCl 50-01-1 10mM (in 1mL H2O)
Guanidine hydrochloride (Guanidine HCl CAS 50-01-1) is a highly alkaline crystalline compound derived from the oxidative metabolism of guanine Functioning primarily as a strong chaotropic agent it disrupts hydrogen bonding and secondary structure in proteins leading to efficient protein denaturation and solubilization Widely utilized in molecular biology and biochemistry Guanidine HCl facilitates protein unfolding for downstream applications such as protein purification refolding studies and RNA extraction protocols where it also serves to inactivate nucleases and other enzymes