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Chlorogenic acid (327-97-9) is a small-molecule modulator primarily involved in the regulation of oxidative stress and inflammation It acts by scavenging reactive oxygen species (ROS) and inhibiting inflammatory pathways including suppression of cytokine expression and NF- B signaling Chlorogenic acid also exhibits antiviral activity through inhibition of viral entry and replication as demonstrated in cell-culture assays Reported IC50 values typically range from approximately 40 80 M depending on experimental conditions cell types and bioassays Based on these pharmacological properties chlorogenic acid holds research potential in oxidative stress-related disorders inflammation pathogenesis viral pathogenicity and hepatotoxicity models
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3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More