Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. It inhibits NF-κB signaling-pathway activation and has anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
- Isolated from Smilax glabra Roxb.
- Inhibits NF-κB signaling-pathway activation.
- Possesses anti-inflammatory effects.
- Possesses analgesic effects.
- Possesses diuresis effects.
- Possesses detumescence effects.
- Possesses antibiosis effects.
- Markedly reduces LPS-increased myeloperoxidase activity in mice.
- Decreases the production of inflammatory mediators (iNOS and COX-2).
- Suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.