Phenylpropanoids and polyketides
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Indofine Chemical Linarin With Hplc, 5 Mg
LINARIN with HPLC, Flavonoid & Coumarins, 480-36-4, 98.5% by HPLC, 5 mg
Medchemexpress LLC Luteolin | 491-70-3 | MFCD00006839 | 99.51% | 286.24 | 50 MG
Luteolin, a flavanoid compound, is a potent Nrf2 inhibitor. It exhibits anti-inflammatory and anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, such as human non-small lung cancer cells.
- Acts as a potent Nrf2 inhibitor
- Exhibits anti-inflammatory and anti-cancer properties
- Induces apoptosis and cell cycle arrest
- Inhibits metastasis and angiogenesis
- Effective in various cancer cell lines
- Utilized for assessing cell viability
- Applied in immunofluorescence analysis
- Used for hematoxylin and eosin staining
- Investigated for effects on protein levels via western blotting
Medchemexpress LLC Apigenin (Standard) | 520-36-5 | 270.24 | 25 MG
Apigenin (Standard) is the analytical standard of Apigenin, intended for research and analytical applications. It is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Reference standard supplied assay
- For research use only
Cayman Chemical EpIcatechIn Galate 10mg
A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 25 MG
Luteolin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) activities. It is a solid, white to light yellow in color, and is intended for research use only. This compound inhibits NO production and mRNA expression of various inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
- Inhibits matrix metalloproteinases (MMP) activities
- Inhibits NO production and mRNA expression of inflammatory mediators
- Improves depression-like and stress coping behaviors in mouse models
- Available as a white to light yellow solid
- For research use only
Medchemexpress LLC Engeletin | 572-31-6 | 434.39 | 10 MM/1 ML
Engeletin is a flavanonol glycoside isolated from *Smilax glabra Roxb.* It inhibits NF-κB signaling-pathway activation and has anti-inflammatory, analgesic, diuretic, detumescent, and antibiotic effects.
- Inhibits NF-κB signaling-pathway activation.
- Possesses anti-inflammatory effects.
- Exhibits analgesic properties.
- Has diuresis effects.
- Shows detumescence effects.
- Demonstrates antibiosis effects.
- Reduces LPS-increased myeloperoxidase activity in mice.
- Decreases the production of inflammatory mediators (iNOS and COX-2).
- Suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.
eMolecules Sophoricoside | 152-95-4 | | 1g
Chem-Impex | Sophoricoside | 1g | 510432077 | 32294 | | 152-95-4 | | 432.381 | C21H20O10
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Medchemexpress LLC HY-N1475 5mg Medchemexpress, Nicotiflorin CAS:17650-84-9 Purity:>98%
Medchemexpress, HY-N1475 5mg Nicotiflorin CAS:17650-84-9 Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Flos Carthami. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC ASTILBIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. purity: 99%
Medchemexpress LLC Engeletin | 572-31-6 | 99.9% | 434.39 g/mol | C21H22O10 | 10 MG
Engeletin is a flavanonol glycoside reported to inhibit NF-κB signaling and to exhibit anti-inflammatory, analgesic, diuretic, and antibacterial effects. It is intended for research use only and has high solubility in DMSO but is essentially insoluble in water.
- Inhibits NF-κB signaling pathway.
- Shows anti-inflammatory and analgesic activity.
- High solubility in DMSO, insoluble in water.
- High purity (99.9%).
- Provided as a small-mass research reagent suitable for in vitro studies.
Apexbio Technology LLC Naringin 10236-47-2 10mM (in 1mL DMSO)
Naringin (CAS 10236-47-2) is a flavanone glycoside predominantly isolated from the fruit of Citrus paradisi Macfadyen (grapefruit) It is recognized for modulating various cellular pathways including inhibition of oxidative stress and inflammation through interaction with NF- B and MAPK signaling cascades Naringin has demonstrated antioxidative anti-inflammatory and potential anti-carcinogenic properties in cellular and animal models Widely used in biomedical research it serves as a tool compound for investigating mechanisms underlying chronic diseases metabolic syndromes and the modulation of drug-metabolizing enzymes For optimal stability it should be stored in a tightly sealed container under cool dry conditions
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C₃₂H₂₈F₃N₅O₄ | 50 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487 and functions as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with a purity of 99.94%.
- Functions as an antagonist of the chemokine receptor CXCR3
- High purity of 99.94%
- Supplied as a solid
- Soluble in DMSO
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 100 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487, which acts as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with high purity.
- High purity: 99.94%
- Antagonist of chemokine receptor CXCR3
- Stable as powder at -20°C for 3 years, and 4°C for 2 years
- Stable in solvent at -80°C for 2 years, and -20°C for 1 year
- Soluble in DMSO at 100 mg/mL