Sphingosine-1-phosphate (S1P) acts as an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. It functions as an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. This lipid mediator stimulates DNA synthesis, cell proliferation, and migration.
- Agonist for S1P1-5 receptors and ligand for GPR3, GPR6, GPR12.
- Functions as an intracellular second messenger.
- Mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors.
- Stimulates DNA synthesis, cell proliferation, and migration.
- Derived from sphingomyelin or other membrane phospholipids.