Diterpenoids
Selleck Chemical LLC Docetaxel S1148-250mg
Docetaxel an analog of paclitaxel is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules
Apexbio Technology LLC LDN 57444 668467-91-2 50mg
LDN 57444 (CAS 668467-91-2) is a reversible competitive inhibitor of ubiquitin C-terminal hydrolase-L1 (Uch-L1) displaying an IC50 of 0 88 M It also inhibits Uch-L3 with lower potency (IC50 25 M) In neuronal systems Uch-L1 inhibition by LDN 57444 results in reduced long-term potentiation and basal synaptic transmission effects resembling -amyloid-induced synaptic impairment Additionally in the rat insulinoma cell line INS 832/13 LDN 57444 triggers apoptosis characterized by increased caspase-3 activity and enhanced nuclear CHOP expression suggesting ER-stress associated cell death mechanisms This compound is utilized in neuroscience and cell biology research to investigate ubiquitin pathway modulation and related cellular responses
TARGETMOL CHEMICALS INC Aphidicolin 1MG
Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase alpha and delta, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].
eMolecules 54706-99-9 | Medchem Express | 20-Deoxyingenol | 5mg | 446275477 | HY-N0866 | MFCD30207875 | 332.44 | C20H28O4
Medchem Express | 20-Deoxyingenol | 5mg | 446275477 | HY-N0866 | 54706-99-9 | MFCD30207875 | 332.440 | C20H28O4
Medchemexpress LLC Isophytol (isovegetable alcohol) | 505-32-8 | MFCD00048380 | 99.7% | 296.53 | C20H40O | 100 G
Isophytol (isovegetable alcohol) is a branched-chain diterpenoid alcohol provided for research use as a biochemical assay reagent. It is a clear, oily organic compound (C20H40O, MW 296.53) commonly used in biochemical and analytical applications; manufacturer-stated purity is approximately 99.7%.
- Biochemical assay reagent for life-science research.
- High nominal purity suitable for analytical applications.
- Clear, oily liquid form for easy formulation and handling.
- Supplied in multiple pack sizes for laboratory convenience.
Medchemexpress LLC HY-N0134 5mg Medchemexpress, Tanshinone I CAS:568-73-0 Purity:>98%
Medchemexpress, HY-N0134 5mg Tanshinone I CAS:568-73-0 Tanshinone I is an inhibitor of type IIA human recombinant sPLA 2 ( IC 50 =11 μM) and rabbit recombinant cPLA 2 ( IC 50 =82 μM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 5 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. It acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is used to treat cardiovascular disorders. This product is for research use only and not sold to patients.
- Inhibits store-operated Ca2+ entry (SOCE)
- Used to treat cardiovascular disorders
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation
- Suppresses TRPC1 and TRPC6 expression in hypoxic PASMCs
- Inhibits CYP3A4 activity
- Attenuates scopolamine-induced cognitive dysfunctions
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model
- Prevents peritoneal adhesion
Medchemexpress LLC 7-Epi-docetaxel | 153381-68-1 | 98.8% | 807.88 | 1 ML
7-Epi-docetaxel is an impurity of docetaxel, intended for research use only. It is classified as a Microtubule/Tubulin Inhibitor within the Cytoskeleton signaling pathway.
- Impurity of docetaxel
- Classified as a microtubule/tubulin inhibitor
- Involved in cytoskeleton signaling pathway
- Suitable for research applications
Medchemexpress LLC Nab-Paclitaxel 1mg | 1mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Medchemexpress LLC Paclitaxel | 5 MG
Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can cause both mitotic arrest and apoptotic cell death, and it also induces autophagy.
- Naturally occurring antineoplastic agent
- Stabilizes tubulin polymerization
- Causes mitotic arrest
- Causes apoptotic cell death
- Induces autophagy
Medchemexpress LLC 7-Epi-docetaxel | 153381-68-1 | 98.8% | 807.88 | 5 MG
7-Epi-10-oxo-docetaxel is an impurity of docetaxel. This product is for research use only and has not been fully validated for medical applications.
- An impurity of docetaxel
- Purity of 98.76%
- Solid appearance, white to light yellow
- Soluble in DMSO at 100 mg/mL (123.78 mM)
- Targets microtubule/tubulin
- Involved in cell cycle/DNA damage and cytoskeleton pathways
- Store as powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year