Diterpenoids
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 278.32 g/mol | C14H14O4S | 10 MG
Topoisomerase IIα-IN-9 (4,4'-sulfonylbis(2-methylphenol)) is a bisphenol compound that moderately inhibits human DNA topoisomerase II and reduces cell proliferation in selected cell lines. It is supplied for laboratory research; lot-specific purity, solubility, and storage conditions are provided in the product data sheet and Certificate of Analysis.
- Moderate topoisomerase II inhibition (IC50: 571 μM).
- Inhibits K562 cell growth (IC50: 117 μM) and CHO cell growth (IC50: 218 μM).
- Molecular weight 278.32 g/mol and formula C14H14O4S.
- CAS number 16346-97-7 for unambiguous identification.
- Intended for research use; consult Certificate of Analysis for purity and storage.
Apexbio Technology LLC Cryptotanshinone 35825-57-1 20mg
Cryptotanshinone (CAS 35825-57-1) is a bioactive diterpene quinone derived from Salvia miltiorrhiza It modulates cellular signaling pathways by interacting with various molecular targets including components of the STAT3 signaling cascade thereby influencing transcriptional activity Studies indicate that cryptotanshinone alters gene expression profiles associated with cellular stress responses and apoptosis Due to its ability to regulate molecular pathways relevant to cancer biology and oxidative stress cryptotanshinone is widely utilized in biomedical research investigating mechanisms of tumor progression chemoprevention and cytoprotection
eMolecules Tanshinone i | 568-73-0 | MFCD00210563 | 1g
Combi-Blocks, Inc. | Tanshinone i | 1g | 603145422 | QC-9410 | 95.000 | 568-73-0 | MFCD00210563 | 276.291 | C18H12O3
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AdipoGen Aphidicolin 17-acetate
Chemical. CAS 51103-57-2. Formula C22H36O5. MW 380.5. Isolated from Phoma sp. BS 7210. Phytotoxin inhibits root growth of seeding. Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis competition with dCTP.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.
- Inhibits DNA polymerase α and δ.
- Functions as an antibiotic from *Cephalosporium aphidicola*.
- Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
- Modulates cell cycle, arresting cells at G2 phase.
- Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
- Aphidicolin glycinate demonstrates anti-tumor activity in murine models.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 50 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola* and inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibitor of DNA polymerase α and δ
- Prevents mitotic cell division
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
AdipoGen (+)-Aphidicolin,Chemical. CAS: 38966-21-1
(+)-Aphidicolin, AdipoGen Life Sciences. Chemical. CAS: 38966-21-1. Formula: C20H34O4. MW: 338.5. Isolated from Phoma sp. BS 7210. Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA methylation/demethylation modulator. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
AG Scientific Inc Aphidicolin, 1 MG
Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-alpha. It also works on other DNA polymerases, however it does not work on DNA polymerase-alpha. Viruses inducing DNA polymerase-alpha, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study. Isolated from Nigrospora oryzae.CAS Number: 38966-21-1Molecular Weight: 338.5Chemical Formula: C20H34O4Solubility: Methanol: Clear colorless solution at 10 mg/mlStorage Temperature: 2-8CResearch or further manufacturing use only, not for food or drug use.
AdipoGen -Aphidicolin
Chemical. CAS 38966-21-1. Formula C20H34O4. MW 338.5. Isolated from Phoma sp. BS 7210. Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA methylation/demethylation modulator. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
Cayman Chemical -AphIdIcolIn 1mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospora sphaerica | 38966-21-1 | MFCD00083214 | 1mg
Aphidicolin from Nigrospora sphaerica | 38966-21-1 | MFCD00083214 | 1mg
Cayman Chemical -AphIdIcolIn 25mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
TARGETMOL CHEMICALS INC Aphidicolin 1MG
Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase alpha and delta, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].
eMolecules Medchem Express / 20-Deoxyingenol / 5mg / 446275477 / HY-N0866 / / 54706-99-9 / MFCD30207875 / 332.440 / C20H28O4
Medchem Express / 20-Deoxyingenol / 5mg / 446275477 / HY-N0866 / / 54706-99-9 / MFCD30207875 / 332.440 / C20H28O4
Medchemexpress LLC HY-N0866 5mg Medchemexpress, 20-Deoxyingenol CAS:54706-99-9 Purity:>98%
Medchemexpress, HY-N0866 5mg 20-Deoxyingenol CAS:54706-99-9 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.