Diterpenoids
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | MFCD00135927 | 50 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It causes extremely prolonged channel opening and calcium influx, leading to cytotoxicity to TRPV1-positive pain fibers or cell bodies.
- Selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor
- Isolated from the Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity to TRPV1-positive pain fibers or cell bodies
Medchemexpress LLC Docetaxel (Standard) | 114977-28-5 | 99.9% | C43H53NO14 | 50 MG
Docetaxel (Standard) is an analytical standard intended for research and analytical applications. It acts as a microtubule depolymerization inhibitor, reducing the effects of bcl-2 and bcl-xL gene expression, arresting the cell cycle at G2/M, and inducing cell apoptosis. This demonstrates anti-cancer activity and makes it suitable for various research experiments.
- Analytical standard for research and analytical applications
- Microtubule depolymerization inhibitor
- Reduces effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M and induces cell apoptosis
- Demonstrates anti-cancer activity
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 5 MG
Docetaxel (Standard) is the analytical standard of Docetaxel, intended for research and analytical applications. Docetaxel (RP-56976) acts as a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and induces cell apoptosis, demonstrating anti-cancer activity.
- Serves as a grade of analytical standard, providing a reference standard for assays
- Commonly utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS
Cayman Chemical Mulberry leaf Phytol 100g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
AdipoGen Docetaxel (5 mg)
Docetaxel (5 mg), Adipogen Life Sciences. Chemical. CAS: 114977-28-5. Formula: C43H53NO14. MW: 807.88. Synthetic. Anticancer agent. Semisynthetic analog of taxol (paclitaxel). Inhibits microtubule disassembly and inhibits cell replication. Binds to and stabilizes the beta−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest at G2/M and apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation. Displays potent and broad antineoplastic properties, used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Also studied for use as a radiation-sensitizing agent.
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA >=97% (HPLC) | 568-72-9 | MFCD00238692 | 25MG
Tanshinone IIA >=97% (HPLC) | Purity: >=97% (HPLC) | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 25MG
Medchemexpress LLC HY-N0174 50mg , Cryptotanshinone Cryptotanshinon;Tanshinone c CAS:35825-57-1 Purity:98%
Medchemexpress, HY-N0174 50mg Cryptotanshinone Cryptotanshinon;Tanshinone c CAS:35825-57-1 Formula:C19H20O3 Purity:98% Cryptotanshinone is a potent STAT3 inhibitor with IC 50 of 4.6 μM, and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (5E,9E,13E)-Teprenone | 3796-63-2 | 99.9% | 100 MG
(5E,9E,13E)-Teprenone is an isomer with antiulcer activity. It induces the transcriptional activation of HSP genes, which may enhance gastric mucosal defense under stress conditions.
- Antiulcer activity.
- Induces transcriptional activation of heat shock protein protein genes.
- May increase gastric mucosal defense at conditions of stress.
- Available in various quantities.
- Purity of 99.9%.
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Medchemexpress LLC Tanshinone IIA anhydride | 61077-78-9 | 310.34 | 5 MG
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor. It has Ki values of 1.9 nM for human CE1 and 1.4 nM for the human intestinal CE (hiCE).
- Potent and irreversible human carboxylesterase (CE) inhibitor.
- Ki values of 1.9 nM for human CE1.
- Ki values of 1.4 nM for human intestinal CE (hiCE).
Medchemexpress LLC Phytol (Standard) | 150-86-7 | 25 MG
Phytol (Standard) is an orally active diterpenoid alcohol that serves as an analytical standard. It can be extracted from chlorophyll and exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. This product is intended for research and analytical applications.
- Analytical standard for research and analytical applications
- Extracted from chlorophyll
- Exhibits antioxidant activity
- Exhibits anti-inflammatory activity
- Exhibits anti-schistosomiasis activity
- Exhibits antibacterial activity
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
TARGETMOL CHEMICALS INC 7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells. Purity 98.05%