Diterpenoids
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 5 MG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. This compound is suitable for research applications.
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
Selleck Chemical LLC Docetaxel S1148-1g
Docetaxel an analog of paclitaxel is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules
Selleck Chemical LLC 10-deacetyl-paclitaxel S3933-5mg
10-deacetyl-paclitaxel (10-DAT Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel
Selleck Chemical LLC Docetaxel S1148-250mg
Docetaxel an analog of paclitaxel is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules
Selleck Chemical LLC Docetaxel Trihydrate
Docetaxel (RP56976 NSC 628503) an analog of paclitaxel is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 100mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 25 MG
Resiniferatoxin, also known as (+)-Resiniferatoxin, is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. Isolated from the *Euphorbia resinifera* plant, this compound eliminates TRPV1+ primary sensory afferents and can blunt cardiac sympathetic afferent reflex for an extended period. This product is intended for research use only.
- Selective agonist for the TRPV1 receptor
- Isolated from the *Euphorbia resinifera* plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
Selleck Chemical LLC LDN-57444
LDN-57444 is a reversible competitive proteasome inhibitor for Uch-L1 with IC50 of 0 88 M 28-fold selectivity over isoform Uch-L3
AG Scientific Inc Aphidicolin, 1 MG
Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-alpha. It also works on other DNA polymerases, however it does not work on DNA polymerase-alpha. Viruses inducing DNA polymerase-alpha, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study. Isolated from Nigrospora oryzae.CAS Number: 38966-21-1Molecular Weight: 338.5Chemical Formula: C20H34O4Solubility: Methanol: Clear colorless solution at 10 mg/mlStorage Temperature: 2-8CResearch or further manufacturing use only, not for food or drug use.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 50 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola* and inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibitor of DNA polymerase α and δ
- Prevents mitotic cell division
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
Medchemexpress LLC 7-Epi-docetaxel | 153381-68-1 | 98.8% | 807.88 | 1 ML
7-Epi-docetaxel is an impurity of docetaxel, intended for research use only. It is classified as a Microtubule/Tubulin Inhibitor within the Cytoskeleton signaling pathway.
- Impurity of docetaxel
- Classified as a microtubule/tubulin inhibitor
- Involved in cytoskeleton signaling pathway
- Suitable for research applications
Cayman Chemical 10-acetyl Docetaxel 50mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)