Diterpenoids
AdipoGen Docetaxel
Chemical. CAS 114977-28-5. Formula C43H53NO14. MW 807.88. Synthetic. Anticancer agent. Semisynthetic analog of taxol paclitaxel. Inhibits microtubule disassembly and inhibits cell replication. Binds to and stabilizes the beta−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest at G2/M and apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation. Displays potent and broad antineoplastic properties, used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Also inhibits pro-angiogenic factors such as vascular endothelial growth factor VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Also studied for use as a radiation-sensitizing agent.
Selleck Chemical LLC Paclitaxel S1150-100mg
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Medchemexpress LLC Tanshinone IIA (Dan Shen ketone) | 568-72-9 | 99.78% | 294.34 | 5 MG
Tanshinone IIA is a primary component found in the root of Salvia miltiorrhiza Bunge. It may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2, and has anti-tumor effects including inhibiting tumor cell proliferation, disrupting the tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer.
- Has antiproliferative activity against various cell lines
- Protects rat myocardium-derived H9C2 cells against apoptosis
- Blocks the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 5 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization, causing mitotic arrest and apoptotic cell death, and also induces autophagy. This compound serves as a reference standard for various research applications.
- Analytical standard for research and analytical applications
- Stabilizes tubulin polymerization
- Induces mitotic arrest and apoptotic cell death
- Induces autophagy
- Reference standard for assays
- Used in HPLC, GC, and MS experiments
- White to off-white solid appearance
- Molecular weight is 853.91
- Derived from Taxaceae family plants (*Taxus chinensis*)
Enzo Life Sciences Tanshinone IIA (25mg). CAS: 568-72-9
Tanshinone IIA is a diterpenoid naphthoquinone found in the traditional Chinese medicine Tanshen (Salvia sp). It inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50=0.22 µM) and induces apoptosis in a variety of cell lines Purity: ≥93% (HPLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml). Long Term Storage: +4°C.
Medchemexpress LLC Tanshinone IIA sulfonate (sodium) | 69659-80-9 | 396.39 | 25 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE). This compound is primarily used to treat various cardiovascular disorders. It is supplied as a pink to red solid with a purity of 99.77%.
- Acts as an inhibitor of store-operated Ca2+ entry (SOCE).
- Used to treat cardiovascular disorders.
- Supplied as a pink to red solid.
- Purity of 99.77%.
- Shipped at room temperature within the continental US.
- Stored at 4°C in sealed containers, away from moisture.
- Unstable in solutions, fresh preparation is recommended for use.
Medchemexpress LLC Docetaxel (Standard) | 114977-28-5 | 99.9% | C43H53NO14 | 50 MG
Docetaxel (Standard) is an analytical standard intended for research and analytical applications. It acts as a microtubule depolymerization inhibitor, reducing the effects of bcl-2 and bcl-xL gene expression, arresting the cell cycle at G2/M, and inducing cell apoptosis. This demonstrates anti-cancer activity and makes it suitable for various research experiments.
- Analytical standard for research and analytical applications
- Microtubule depolymerization inhibitor
- Reduces effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M and induces cell apoptosis
- Demonstrates anti-cancer activity
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Nab-Paclitaxel 10mg | 10mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Sigma Aldrich Fine Chemicals Biosciences Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | 114977-28-5 | MFCD00800737 |
Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 |
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 5 MG
Docetaxel (Standard) is the analytical standard of Docetaxel, intended for research and analytical applications. Docetaxel (RP-56976) acts as a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and induces cell apoptosis, demonstrating anti-cancer activity.
- Serves as a grade of analytical standard, providing a reference standard for assays
- Commonly utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS