Diterpenoids
Medchemexpress LLC Tanshinone IIA sulfonate (sodium) | 69659-80-9 | 396.39 | 25 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE). This compound is primarily used to treat various cardiovascular disorders. It is supplied as a pink to red solid with a purity of 99.77%.
- Acts as an inhibitor of store-operated Ca2+ entry (SOCE).
- Used to treat cardiovascular disorders.
- Supplied as a pink to red solid.
- Purity of 99.77%.
- Shipped at room temperature within the continental US.
- Stored at 4°C in sealed containers, away from moisture.
- Unstable in solutions, fresh preparation is recommended for use.
AdipoGen Paclitaxel
Chemical. CAS 33069-62-4. Formula C47H51NO14. MW 853.9. Isolated from the bark of the pacific yew tree Taxus brevifolia. Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposis sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases CKDs and the c-Jun N-terminal kinase/stress activated protein kinase JNK/SAPK. Immunosuppressor. Immunostimulant. Antiproliferative agent for the prevention of restenosis. TRAIL sensitizer
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospor5MG
Aphidicolin from Nigrospor5MG
Medchemexpress LLC HY-N0174 50mg , Cryptotanshinone Cryptotanshinon;Tanshinone c CAS:35825-57-1 Purity:98%
Medchemexpress, HY-N0174 50mg Cryptotanshinone Cryptotanshinon;Tanshinone c CAS:35825-57-1 Formula:C19H20O3 Purity:98% Cryptotanshinone is a potent STAT3 inhibitor with IC 50 of 4.6 μM, and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3958841 SIGMA PACLITAXEL 300MG
Medchemexpress LLC Docetaxel Standard | 114977-28-5 | C43H53NO14 | 25MG
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity
Abcam Paclita x el, Anticancer agent, 50MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Paclitaxel | 33069-62-4 | 99.97% | C47H51NO14 | 5 G
Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can cause both mitotic arrest and apoptotic cell death, and it also induces autophagy.
- Naturally occurring antineoplastic agent.
- Stabilizes tubulin polymerization.
- Causes mitotic arrest.
- Induces apoptotic cell death.
- Induces autophagy.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | MFCD00135927 | 50 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It causes extremely prolonged channel opening and calcium influx, leading to cytotoxicity to TRPV1-positive pain fibers or cell bodies.
- Selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor
- Isolated from the Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity to TRPV1-positive pain fibers or cell bodies
TARGETMOL CHEMICALS INC Cucurbitacin IIA 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3. Purity 98.62%
TARGETMOL CHEMICALS INC Tanshinone IIA sulfonate sodiu
Also available in 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 uM) inhibits hypoxia-induced PKG and PPAR-gamma downregulation in PASMCs and distal pulmonary arteries of rats. Purity 99.9%
Medchemexpress LLC Tanshinone IIA (Dan Shen ketone) | 568-72-9 | 99.78% | 294.34 | 5 MG
Tanshinone IIA is a primary component found in the root of Salvia miltiorrhiza Bunge. It may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2, and has anti-tumor effects including inhibiting tumor cell proliferation, disrupting the tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer.
- Has antiproliferative activity against various cell lines
- Protects rat myocardium-derived H9C2 cells against apoptosis
- Blocks the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells