Diterpenoids
Medchemexpress LLC Aphidicolin | 38966-21-1 | 1 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola*, inhibiting cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Interferes with DNA polymerase activity
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Apexbio Technology LLC Phytol 150-86-7 250g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models
Medchemexpress LLC (5E,9E,13E)-Teprenone | 3796-63-2 | 99.9% | 100 MG
(5E,9E,13E)-Teprenone is an isomer with antiulcer activity. It induces the transcriptional activation of HSP genes, which may enhance gastric mucosal defense under stress conditions.
- Antiulcer activity.
- Induces transcriptional activation of heat shock protein protein genes.
- May increase gastric mucosal defense at conditions of stress.
- Available in various quantities.
- Purity of 99.9%.
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 5 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*. This compound has been extensively used for treating cardiovascular diseases and demonstrates an entry-blocking effect against MERS-CoV.
- Extracted from *Salvia miltiorrhiza Bunge*
- Used for treating cardiovascular diseases
- Exhibits entry-blocking effect for MERS-CoV
- Attenuates atherosclerosis in ApoE-/- mice
- Inhibits LOX-1, NOX4, and NF-κB expression in aorta
- Improves cardiac function and reduces infarct size in myocardial ischemia-reperfusion rats
- Induces caspase-dependent apoptosis and autophagy in colon cancer cells
- Potentially a safe, high-throughput screening compound for MERS-CoV entry inhibitors
- Purity: 99.57%
- Appearance: Solid, brown to red
Medchemexpress LLC Tanshinone I | 568-73-0 | 98.8% | 276.29 | 100 MG
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2. It demonstrates anti-inflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. It is for research use only.
- Inhibits type IIA human recombinant sPLA2 and rabbit recombinant cPLA2
- Shows anti-inflammatory activity in animal models
- For research use only
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-1g
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
![Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000295618.png-250.jpg)
Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG
Tanshinone IIA sulfonate sodium is the sodium sulfonate derivative of tanshinone IIA. It is a water-soluble small molecule reported to inhibit store-operated Ca2+ entry (SOCE) and is used in research on cardiovascular disorders and calcium-signaling pathways.
- Water-soluble sodium sulfonate derivative suitable for aqueous assays.
- Reported inhibitor of store-operated Ca2+ entry (SOCE).
- Applicable to cardiovascular and calcium-signaling research models.
- Characterized chemical identifiers: formula C19H17NaO6S and molecular weight 396.4 g/mol.
- High reported purity (≈99.8%) for research applications.
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 1 MG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a natural antineoplastic agent that works by stabilizing tubulin polymerization. This product is strictly for research purposes and is not intended for patient use. Deuteration, the process of incorporating stable heavy isotopes into drug molecules, is primarily employed as a tracer for quantitation during the drug development process and can impact the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stabilizes tubulin polymerization
- For research use only
Medchemexpress LLC Paclitaxel | 33069-62-4 | 99.97% | C47H51NO14 | 5 G
Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can cause both mitotic arrest and apoptotic cell death, and it also induces autophagy.
- Naturally occurring antineoplastic agent.
- Stabilizes tubulin polymerization.
- Causes mitotic arrest.
- Induces apoptotic cell death.
- Induces autophagy.
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 G
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity