Diterpenoids
TARGETMOL CHEMICALS INC Tanshinone IIA sulfonate sodiu
Also available in 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 uM) inhibits hypoxia-induced PKG and PPAR-gamma downregulation in PASMCs and distal pulmonary arteries of rats. Purity 99.9%
AdipoGen Resiniferatoxin high purity
Chemical. CAS 57444-62-9. Formula C37H40O9. MW 628.72. Isolated from Euphorbia resinifera. Highly potent TRPV1 agonist. Resiniferatoxin RTX is a phorbol-related diterpene ester analog of capsaicin. RTX is a highly potent transient receptor potential vanilloid 1 TRPV1 agonist Ki=43pM and acts as a selective modulator of primary afferent neurons. TRPV1 or vanilloid receptor 1 is a non-selective cation channel that is involved in the detection and transduction of nociceptive stimuli. TRPV1 is expressed in the plasma membrane of sensory neurons and stimulation by RTX causes this ion channel to become permeable to cations, especially calcium. The influx of cations causes the neuron to depolarize, transmitting signals similar to those that would be transmitted if the innervated tissue were being burned or damaged. This stimulation is followed by desensitization and analgesia, in part because the nerve endings die from calcium overload.
Medchemexpress LLC Nab-Paclitaxel 10mg | 10mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Medchemexpress LLC Nab-Paclitaxel 100mg | 100mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Selleck Chemical LLC Paclitaxel S1150-100mg
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
Sigma Aldrich Fine Chemicals Biosciences Geranylgeranylacetone | 6809-52-5 | MFCD00869547 | 10MG
Geranylgeranylacetone | Purity: >=98% (HPLC) | Mol Wt: 330.55 | 6809-52-5 | MFCD00869547 | 10MG
Sigma Aldrich Fine Chemicals Biosciences Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | 114977-28-5 | MFCD00800737 |
Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 |
Abcam Paclita x el, Anticancer agent, 50MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | 38966-21-1 | MFCD00083214 | 1MG
Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | Purity: >=98% (TLC) | Mol Wt: 338.48 | 38966-21-1 | MFCD00083214 | 1MG
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 100 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*, which has been widely used for treating cardiovascular diseases. It exhibits an entry-blocking effect for MERS-CoV.
- Natural compound extracted from *Salvia miltiorrhiza Bunge*.
- Used for treating cardiovascular diseases.
- Exhibits an entry-blocking effect for MERS-CoV.
Apexbio Technology LLC Tanshinone-IIA-sulfonic-sodium
Tanshinone IIA---sulfonic sodium (CAS No 69659-80-9) is a water-soluble derivative of tanshinone IIA primarily used in biomedical research as an anti-inflammatory and anticancer agent Originating from the root of Salvia miltiorrhiza it exerts its effects through modulation of various signaling pathways including NF- B and MAPK leading to apoptosis and reduction of inflammatory responses In vitro activity generally ranges from nanomolar to low micromolar concentrations depending on the assay conditions It is frequently employed in cancer cell lines and inflammatory models to explore its therapeutic potential and mechanisms Animal studies often utilize it to evaluate efficacy and safety as a potential pharmacological agent Experimental concentrations typically depend on the specific research design allowing flexibility for different objectives yet maintaining relevance for drug screening and development purposes
