Diterpenoids
Cayman Chemical Phytol, Purity: ≥85% (mixture of isomers), CAS: 7541-49-3, 100 g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Cayman Chemical 6α-hydroxy Paclitaxel, Purity: ≥95%, CAS: 153212-75-0, 5 mg
A metabolite of paclitaxel
Cayman Chemical Paclitaxel, Purity: ≥98%, CAS: 33069-62-4, 100 mg
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 5 MG
Docetaxel (Standard) is the analytical standard of Docetaxel, intended for research and analytical applications. Docetaxel (RP-56976) acts as a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and induces cell apoptosis, demonstrating anti-cancer activity.
- Serves as a grade of analytical standard, providing a reference standard for assays
- Commonly utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 5 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization, causing mitotic arrest and apoptotic cell death, and also induces autophagy. This compound serves as a reference standard for various research applications.
- Analytical standard for research and analytical applications
- Stabilizes tubulin polymerization
- Induces mitotic arrest and apoptotic cell death
- Induces autophagy
- Reference standard for assays
- Used in HPLC, GC, and MS experiments
- White to off-white solid appearance
- Molecular weight is 853.91
- Derived from Taxaceae family plants (*Taxus chinensis*)
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 G
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity
Medchemexpress LLC Paclitaxel | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 100 MG
Paclitaxel is an analytical standard and a naturally occurring antineoplastic agent. It is intended for research and analytical applications, stabilizing tubulin polymerization, causing mitotic arrest, apoptotic cell death, and inducing autophagy. This compound serves as a reference standard for assays and is utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for paclitaxel
- Naturally occurring antineoplastic agent
- Stabilizes tubulin polymerization
- Causes mitotic arrest
- Induces apoptotic cell death
- Induces autophagy
- Reference standard for assays
- Used in HPLC, GC, and MS experiments
Medchemexpress LLC Docetaxel (Standard) | 114977-28-5 | 99.9% | C43H53NO14 | 50 MG
Docetaxel (Standard) is an analytical standard intended for research and analytical applications. It acts as a microtubule depolymerization inhibitor, reducing the effects of bcl-2 and bcl-xL gene expression, arresting the cell cycle at G2/M, and inducing cell apoptosis. This demonstrates anti-cancer activity and makes it suitable for various research experiments.
- Analytical standard for research and analytical applications
- Microtubule depolymerization inhibitor
- Reduces effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M and induces cell apoptosis
- Demonstrates anti-cancer activity
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 50 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, a naturally occurring antineoplastic agent. It is intended for research and analytical applications, serving as a reference standard for assays.
- Stabilizes tubulin polymerization.
- Causes both mitotic arrest and apoptotic cell death.
- Induces autophagy.
- Used in qualitative, quantitative, and methodological research experiments.
- Commonly used in HPLC, GC, and MS applications.
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Sigma Aldrich Fine Chemicals Biosciences Docetaxel | 114977-28-5 | MFCD00800737 | 5mg
Docetaxel | Purity: 97% | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 | 5mg
Apexbio Technology LLC PACLITAXEL-D5-1MG
Paclitaxel-d5 (CAS No 1129540-33-5) is a deuterated analog of paclitaxel used in biomedical research primarily to study the pharmacokinetics and metabolism of the parent compound Originating from the bark of the Pacific yew tree paclitaxel acts by stabilizing microtubules and inhibiting their depolymerization thus blocking cell division and inducing apoptosis in cancer cells Its mechanism of action specifically affects the tubulin-microtubule pathway Paclitaxel-d5 exhibits activity in the nanomolar to low micromolar range in vitro making it a valuable tool in cell models and animal studies aimed at understanding cancer cell sensitivity or resistance to taxanes It is frequently used in drug screening assays to evaluate potential therapeutic efficacy or investigate drug interactions Experimental concentrations typically depend on the specific research design
Cayman Chemical 7-epi Paclitaxel, Purity: ≥98%, CAS: 105454-04-4, 10 mg
An active metabolite of paclitaxel; exhibits properties comparable to paclitaxel on both cells and in vitro microtubule polymerization
Selleck Chemical LLC LDN-57444
LDN-57444 is a reversible competitive proteasome inhibitor for Uch-L1 with IC50 of 0 88 M 28-fold selectivity over isoform Uch-L3
Medchemexpress LLC Paclitaxel | 33069-62-4 | C47H51NO14 | 1 G
Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can induce mitotic arrest and apoptotic cell death, and also autophagy.
- Stabilizes tubulin polymerization
- Induces mitotic arrest
- Induces apoptotic cell death
- Induces autophagy
- Used in cardiovascular disease research
- Used in cancer research