Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1782098-79-6 | 99.57% | 1586.82 | 5 MG
Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM. It is for research use only and has not been fully validated for medical applications.
- 11-residue cell-permeable cyclic peptide
- Orthosterically inhibits Ras-Raf protein interaction
- IC50 of 120 nM
- For research use only
Medchemexpress LLC Huwentoxin IV | 526224-73-7 | >98% | 1 MG
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50s of 26, 150, 338, and 400 nM, respectively.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- IC50s of 26, 150, 338, and 400 nM, respectively
Medchemexpress LLC Angiopeptin TFA | 2478421-60-0 | 99.01% | 1326.39 | 25 MG
Angiopeptin TFA is a cyclic octapeptide analogue of somatostatin. It acts as a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. It is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA also inhibits adenylate cyclase or stimulates extracellular acidification, making it valuable for research in coronary atherosclerosis.
- Acts as a partial agonist on the release of tritium on CHO hsst2 cells (in vitro).
- Significantly inhibits neointimal formation (in vivo).
- Significantly inhibits coronary artery myointimal proliferation in cardiac allografts (in vivo).
Medchemexpress LLC Sar441255 TFA | 99.9% | 4866.56 (free base) | 1 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It demonstrates high potency with balanced activation of all three target receptors. This compound shows positive acute glucoregulatory effects in diabetic obese monkeys, indicating its potential for metabolic and endocrine disease research, particularly in areas like obesity and type 2 diabetes.
- Potent unimolecular peptide receptor triagonist.
- Displays high potency with balanced activation of three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Relevant for research in metabolic diseases, including obesity and type 2 diabetes.
Medchemexpress LLC Hexa-His TFA | 1456728-20-3 | 99.8% | 954.87 | 25 MG
Hexa-His TFA is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein.
- Consists of 6 His residues
- Used as a metal binding site
- Suitable for recombinant protein applications
- Molecular weight of 954.87
- Purity of 99.8%
- Appearance is solid, white to off-white
- Recommended storage for powder: -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month
- Store sealed and away from moisture
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
Medchemexpress LLC Vm24-toxin TFA | 1373890-79-9 | 3863.59 | 5 MG
Vm24-toxin is a 36-residue peptide that acts as a potent and selective Kv1.3 blocker with a Kd of approximately 3 pM in lymphocytes. It exhibits over 1500-fold affinity for Kv1.3 compared to other tested potassium channels. This toxin attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation.
- Potent and selective Kv1.3 blocker
- Exhibits over 1500-fold affinity for Kv1.3
- Attenuates CD4+ effector memory T cell response
Medchemexpress LLC Gmprga Tfa | 98.1% | 587.69 | 1 MG
GMPRGA (TFA) is the trifluoroacetate salt form of GMPRGA, a compound that plays a role in bacterial processes. It is known for its ability to recognize spAimR within the bacterial cytosol, which subsequently induces lysogeny. This product is intended for research applications only and is not suitable for human use.
- Recognizes spAimR in the bacterial cytosol.
- Induces lysogeny in bacteria.
- For research purposes only.
Medchemexpress LLC P4pal10 TFA | 98.25% | 1409.72 | 5 MG
P4pal10 TFA is the TFA salt form of P4pal10. It acts as an antagonist for protease-activated receptor 4 (PAR4). It inhibits platelet aggregation, tissue factor (TF)-induced thrombin generation, and demonstrates anticoagulant and antithrombotic activities. Additionally, it reduces edema and granulocyte infiltration induced by Carrageenan and ameliorates injury in rats with myocardial ischemia/reperfusion (I/R) models.
- Antagonist for protease-activated receptor 4 (PAR4)
- Inhibits platelet aggregation
- Inhibits tissue factor (TF)-induced thrombin generation
- Demonstrates anticoagulant and antithrombotic activities
- Reduces edema and granulocyte infiltration
- Ameliorates injury in myocardial ischemia/reperfusion (I/R) models
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 1 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule Hsp90 inhibitor used in research to probe Hsp90 biology, induce client protein degradation, and trigger stress responses in cancer cell models.
- Potent Hsp90 inhibition with low-nanomolar cellular activity.
- Promotes degradation of Hsp90 client proteins, including Her2.
- Induces Hsp70 expression and apoptosis in sensitive cancer cells.
- High purity solid suitable for biochemical and cellular assays.
- Available in small research quantities for dose-response studies.
- Stable when stored sealed at recommended temperatures.
Medchemexpress LLC 5-fam-ahx-ll-37 tfa | 98.06% | 4964.72 (free acid) | 1 MG
5-FAM-Ahx-LL-37 TFA is a 5-FAM-labeled human LL-37, a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid. This peptide exhibits a broad spectrum of antimicrobial activity.
- Appears as a solid
- Sequence is {5-FAM-Ahx}-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-R-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
- Ships at room temperature in continental US
- Store powder sealed away from moisture at -80°C for 2 years or -20°C for 1 year
- Store in solvent sealed away from moisture at -80°C for 6 months or -20°C for 1 month
- Soluble in H2O at 16.67 mg/mL (requires ultrasonic assistance)
- Classified as an antimicrobial peptide
Medchemexpress LLC WDR5-IN-4 TFA | 2749300-35-2 | 98.0% | 612.40 | 1 ML
WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. It displaces WDR5 from chromatin and decreases the expression of associated genes, leading to translational inhibition and nucleolar stress. This compound also exhibits anti-cancer activity.
- Inhibits the proliferation of MLL1-rearranged cancer cells MV4:11 and K562 cells with GI50s of 3.20 μM and 25.4 μM respectively, when treated with 0-50 μM for 3 days.
- Arrests the cell cycle of MV4:11 at the sub-G1 phase and induces apoptosis in MV4:11 when treated with 2 μM for 6 days.
- Promotes Hox genes in hindbrains of Rnf220+/- mice at late embryonic stages with an intrauterine injection of 100 μg (single dose).