Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
Medchemexpress LLC Liraglutide TFA | 204656-20-2 | 99.6% | 3751.20 (free base) | 1 MG
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). It can activate GLP-1, leading to insulin release in the presence of increased glucose concentration, and also reduces glucagon secretion in a glucose-dependent manner. It can be used in research on type 2 diabetes.
- Activates GLP-1 receptor
- Leads to insulin release
- Reduces glucagon secretion
- Suitable for type 2 diabetes research
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.07% | 723.74 | 1 MG
UNC8732 (TFA) is a NSD2 inhibitor and degrader.
- NSD2 inhibitor and degrader.
- For research use only.
Medchemexpress LLC GRGDSPC TFA | 99.2% | 804.75 | 5 MG
GRGDSPC TFA is a 7-amino acid thiolated cell adhesion peptide. It is utilized in conjugation reactions with acrylated dextran to regulate the interactions of human mesenchymal stem cells (hMSCs) with photocrosslinkable hydrogels.
- Thiolated cell adhesion peptide
- Composed of 7 amino acids
- Regulates human mesenchymal stem cell interactions
- Suitable for research applications
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
Medchemexpress LLC Vasculotide TFA | 1359657-45-6 | 99.7% | 14000 (average) | 25 MG
Vasculotide TFA is an angiopoietin-1 mimetic that functions as a Tie-2 activator, leading to Tie-2 phosphorylation. This compound exhibits anti-inflammatory and anti-permeability effects, making it relevant for various research applications.
- Ameliorates endotoxin-induced endothelial barrier dysfunction
- Promotes angiogenesis in a mouse model of diabetic ulcer
- Protects mice from vascular leakage
- Reduces mortality in murine abdominal sepsis
- Decreases microvascular leakage
- Improves microcirculatory perfusion in a rat model of hemorrhagic shock
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | 98.74% | 4907.48 | 5 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. This compound is used in antidiabetic research and is for research use only. It is orally active and can also be administered by injection.
- Dual GIP and GLP-1 receptor agonist
- Orally active
- Can be administered by injection
- Suitable for antidiabetic research
Medchemexpress LLC Ω-Agatoxin IVA TFA | 99.10% | 5316.27 | 500 UG
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. It inhibits glutamate exocytosis and calcium influx elicited by high potassium (IC50, 30-225 nM) and also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.
- Potent, selective P/Q type Ca2+ (Cav2.1) channel blocker
- Inhibits glutamate exocytosis and calcium influx
- Blocks release of serotonin and norepinephrine
- No effect on L-type or N-type calcium channels
- Appearance: Solid
- Color: White to off-white
- For research use only
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC VMIP-II (1-21) TFA | 5 MG
vMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. It interacts broadly with CC and CXC chemokine receptors, inhibiting CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM). This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C108H169N33O27S.xC2HF3O2
- Sequence: Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro
- Target: CXCR
- Pathway: GPCR/G protein; immunology/inflammation
Medchemexpress LLC Dendrotoxin-I TFA | 99.1% | 7149.24 | 100 UG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin demonstrates potential for cancer research and is intended for research use only.
- Potent K+ channel blocker: Exhibits IC50s of 0.13-50 nM against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6.
- Neurotoxin with cancer research potential: Implicated in studies exploring its use in cancer research.
- In vivo activity: In an animal model using nude mice with MCF-7 cells, it showed a significant tumor growth inhibition effect when combined with hyperthermia.
Medchemexpress LLC Lys-coenzyme A trifluoroacetate | 98.5% | 1108.82 g·mol⁻1 | C33H54F3N10O21P3S | 5 MG
Lys-CoA TFA is a bisubstrate-mimic inhibitor of the p300 histone acetyltransferase (HAT). It inhibits p300-dependent acetylation (reported IC50 = 50-500 nM) with >100-fold selectivity over PCAF and is intended for use in biochemical and cell-based studies probing p300-mediated acetylation.
- Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM)
- Greater than 100-fold selectivity versus PCAF
- High purity (98.5%) suitable for research applications
- Molecular formula C33H54F3N10O21P3S
- Molecular weight 1108.82 g·mol⁻1
- Supplied as a small-quantity solid for biochemical assays and cell studies
Medchemexpress LLC Tcmcb07 (TFA) | 99.7% | 1230.46 (free base) | 5 MG
TCMCB07 (TFA) is a chemical product from MedChemExpress USA, identified for use as laboratory chemicals and for the manufacture of substances. It is supplied as a solid and is stable under recommended storage conditions.
- Designed for laboratory use and substance manufacturing
- Stable under recommended storage conditions
- Supplied as a solid
- Storage recommended at -80°C for 2 years or -20°C for 1 year (powder)
- Sealed storage, away from moisture and light
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 1 MG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6. This neurotoxin shows potential for cancer research.
- Potent K+ channel blocker
- Targets voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6
- Displays tumor growth inhibition effect with hyperthermia in vivo studies
- White to off-white solid appearance
Medchemexpress LLC CPP9 TFA | 99.9% | 1553.37 | 1 MG
CPP9 TFA is a small, amphipathic, cyclic cell penetrating peptide (CPP). CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome. It can be used for intracellular delivery of therapeutic agents and chemical probes.
- Small, amphipathic, cyclic cell penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficient release from the endosome
- Used for intracellular delivery of therapeutic agents
- Used for intracellular delivery of chemical probes