Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Bibo 3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g/mol | C31H36F3N7O5 | 5 MG
BIBO3304 (trifluoroacetate) is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research tool to probe NPY1R-mediated signaling in pharmacology and neuroscience studies. It is supplied as a high-purity solid and is characterized for receptor binding and in vitro functional assays.
- High potency and selectivity for the NPY Y1 receptor.
- Suitable for in vitro receptor binding and functional assays.
- High reported purity for reproducible experimental results.
- Available as a solid and as a DMSO solution for assay convenience.
- Well characterized with supporting chemical identifiers and structural data.
Medchemexpress LLC Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 100 MG
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. Relamorelin TFA has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist.
- Ki of 0.42 nM for GHS-1a receptor.
- Centrally penetrant.
- Increases growth hormone levels.
- Accelerates gastric emptying.
- Potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.
- Purity: 99.81%.
Medchemexpress LLC Rf470 TFA | 2369899-34-1 | 624.63 | 25 MG
Rf470 TFA is a FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently incorporated into peptidoglycan by bacteria. It exhibits extremely weak fluorescence in its free state, but its fluorescence significantly increases when it is catalytically incorporated into peptidoglycan by transpeptidases.
- Can be used for real-time monitoring of peptidoglycan biosynthesis.
- Can be used for detection of transpeptidase activity.
- Can be used for screening of antibiotics through fluorescence changes.
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
Medchemexpress LLC NLS-StAx-h TFA | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
NLS-StAx-h TFA is a selective, cell-permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. It efficiently inhibits β-catenin-transcription factor interactions and demonstrates anti-proliferation effects on cancer cells, making it suitable for research into Wnt signaling pathways.
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation effects on cancer cells
- Reduces the viability of SW-480 and DLD-1 colorectal cancer cells by more than 80%
- Inhibits the migration of colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC L-Tyrosine, L-tyrosyl-L-lysyl-L-tyrosyl- (TFA) | 98.1% | 749.73 | 5 MG
YKYY TFA is a blood pressure-lowering peptide isolated from the digest of Undaria pinnatifida. This peptide acts as an angiotensin I-converting enzyme (ACE) inhibitor with an IC50 of 64.2 μM. It is suitable for use in hypertension research.
- Antihypertensive peptide
- Angiotensin I-converting enzyme (ACE) inhibitor
- Isolated from the peptic digest of wakame Undaria pinnatifida
- For research use only
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC SIYNFEKL TFA | 99.9% | 1013.14 (free acid) | 5 MG
SIYNFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It stimulates specific T cells in experimental settings to study competitive interactions between T cells.
- Stimulates specific T cells
- Used to study competitive interaction between T cells
- Exhibits low affinity for OT-I T cell receptor (TCR)
- Applicable for detection of CD8+ T cells
Medchemexpress LLC Cppi9 Tfa | 99.9% | 1553.37 | 5 MG
CPP9 TFA is a small, amphipathic, cyclic cell-penetrating peptide (CPP) that binds directly to plasma membrane phospholipids and enters mammalian cells via endocytosis. Its efficient release from the endosome after cellular entry makes it suitable for intracellular delivery of therapeutic agents and chemical probes.
- Efficient release from endosome after cellular entry
- Suitable for intracellular delivery of therapeutic agents
- Suitable for intracellular delivery of chemical probes
- For research use only
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC C-telopeptide TFA | 868.89 (free base) | 25 MG
C-telopeptide TFA is a cross-linked peptide of type I collagen. It is released during bone resorption and has been correlated with bone mineral density (BMD). This product is intended for research use only.
- Cross-linked peptide of type I collagen
- Released during bone resorption
- Correlated with bone mineral density (BMD)
- Sequence: Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
- Target: MMP
- Pathway: Metabolic Enzyme/Protease
Medchemexpress LLC Jbsnf-000028 Tfa | C13H14F3N3O2 | 1 ML
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. It can reduce endogenous MNA levels in U2OS osteosarcoma cells, with an EC50 of 2.5 μM. This compound exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model and can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of NNMT
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Exhibits anti-obesity and anti-diabetic activities
- Useful for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Medchemexpress LLC 4,7,10,13,16-pentaazanonadecanedioic acid ester (TFA) | MFCD34677028 | 98.6% | 1841.72 (free base) | C93H173N5O20S5·xC2HF3O2 | 5 MG
5A2-SC8 TFA is an ionizable amino lipid provided as the trifluoroacetic acid salt for formulation into lipid nanoparticles (LNPs). It is intended for research use to enable efficient delivery of small RNAs, such as siRNA and miRNA, and has documented low in vivo toxicity and COA-verified purity.
- Ionizable amino lipid suitable for LNP formulation.
- Enhances delivery of siRNA and miRNA to target cells.
- Low in vivo toxicity profile reported.
- Provided as the TFA salt to aid formulation and handling.
- COA-verified purity by HPLC (~98.6%).
- Store at -80 °C and protect from light for stability.