Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Tcmcb07 tfa | 1456699-27-6 | 99.69% | 1344.5 g/mol | 1 MG
TCMCB07 TFA is a cyclic nonapeptide, recognized as an orally active and brain-penetrant antagonist of the melanocortin receptor 4 (MC4R). It is noted for its important role in cachexia and exhibits potential transport capabilities.
- Cyclic nonapeptide MC4R antagonist
- Orally active and brain-penetrant
- Important for cachexia research
- Exhibits potential transport capabilities
- Known to stimulate food intake and weight gain in rats
Medchemexpress LLC W1131 TFA 10mM | 2740522-79-4 | C₂₅H₂₀F₃NO₈ | 1 ML
W1131 TFA is a potent STAT3 inhibitor and ferroptosis inducer. It demonstrates anti-cancer properties by inhibiting tumor growth and alleviating chemoresistance in gastric cancer models. W1131 TFA regulates critical cellular processes including the cell cycle, DNA damage response, and oxidative phosphorylation, specifically impacting the IL6-JAK-STAT3 and ferroptosis pathways.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Modulates oxidative phosphorylation
- Impacts IL6-JAK-STAT3 pathway
- Affects ferroptosis pathway
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.07% | 723.74 | 1 MG
UNC8732 (TFA) is a NSD2 inhibitor and degrader.
- NSD2 inhibitor and degrader.
- For research use only.
Medchemexpress LLC LIH383 | 2866266-58-0 | 99.8% | 997.22 | 1 MG
LIH383 is an agonist of ACKR3 (CXCR7) with an EC50 of 0.61 nM. It efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling.
- Agonist of ACKR3 (CXCR7)
- Efficiently induces recruitment of β-arrestin to ACKR3
- Does not trigger typical G protein signaling
Medchemexpress LLC SAIRGA (TFA) | 99.6% | 573.64 | 1 MG
SAIRGA (TFA) is a chemical derived from the phages phi3T, capable of recognizing phAimR in the bacterial cytosol to induce lysogeny. This product is suitable for use as a laboratory chemical in the manufacture of various substances.
- Solid appearance
- Has a purity of 99.6%
- Features a molecular weight of 573.64
- Stable under recommended storage conditions
- Suitable for research applications only
- Store at -80°C for up to 2 years or -20°C for up to 1 year (powder, sealed storage, away from moisture and light)
Medchemexpress LLC PSMA I&S TFA | 98.2% | 1413.43 | 1 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, appearing as a white to off-white solid.
- Target PSMA
- Inhibits immunology/inflammation pathway
- Soluble in DMSO (100 mg/mL)
- Soluble in various in vivo dissolution methods
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 1 MG
Tpp-CAQK TFA is an engineered mitochondrial compound that can bind to mitochondria, enabling the construction of Mito-Tpp-CAQK TFA with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Can bind to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances macrophage phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in mice after spinal cord injury
- For research use only
Medchemexpress LLC JPS014 TFA | 98.12% | C48H60F3N7O9S | 25 MG
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC). It degrades class I histone deacetylase (HDAC) and is a potent HDAC1/2 degrader. This degradation correlates with a greater number of total differentially expressed genes and enhanced apoptosis in HCT116 cells.
- Benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC)
- Degrades class I histone deacetylase (HDAC)
- Potent HDAC1/2 degrader
- Correlates with greater total differentially expressed genes
- Enhances apoptosis in HCT116 cells
Medchemexpress LLC Thymocartin TFA 25mg | 25MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects