Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | >97.2% | 514.51 | 1 ML
EZM0414 TFA, also known as SETD2-IN-1 TFA, is a potent, selective, and orally active inhibitor of SETD2 (IC50=18 nM in biochemical assay; IC50=34 nM in cellular assay). It is used for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active SETD2 inhibitor.
- Inhibits proliferation of MM and DLBCL cell lines.
- Shows robust tumor growth regressions in xenograft models.
- Well-tolerated in animal studies.
- Exhibits high oral bioavailability in rats and mice.
- Soluble in DMSO and water for in vitro applications.
- Provides various in vivo solubility protocols for clear solutions.
Medchemexpress LLC PBA-1105 TFA | 99.6% | 754.83 | 5 MG
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. It selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. This compound increases the autophagic flux of Ub-conjugated aggregates and induces autophagic degradation of misfolded proteins and aggregates at nanomolar concentrations. It is for research use only.
- Induces p62 self-oligomerization.
- Selectively binds to exposed hydrophobic regions of misfolded proteins.
- Facilitates degradation via the autophagic pathway.
- Increases the autophagic flux of Ub-conjugated aggregates.
- Induces autophagic degradation of mutant tau and misfolded proteins.
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Medchemexpress LLC DOTA-ADIBO TFA | 1374865-01-6 | 99.1% | 776.76 g/mol | C36H43F3N6O10 | 5 MG
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator supplied as the trifluoroacetic acid salt. It enables biomolecule conjugation via strain-promoted, copper-free azide-alkyne cycloaddition and supports construction of fusion chelator systems for radiometal labeling and PET radiotracer synthesis. The compound is provided as a high-purity solid with DMSO solubility and requires protected, low-temperature storage.
- DOTA-derived bifunctional chelator for copper-free click conjugation.
- Facilitates radiometal labeling for PET radiotracer synthesis.
- High reported purity suitable for research applications.
- Soluble in DMSO (≈100 mg/mL); may require sonication.
- Store under nitrogen, protect from light, keep at low temperatures.
- Provided as a TFA salt to aid handling and stability.
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.07% | 723.74 | 1 MG
UNC8732 (TFA) is a NSD2 inhibitor and degrader.
- NSD2 inhibitor and degrader.
- For research use only.
Pfaltz & Bauer Trifluoroacetic acid anhydride 100G | 407-25-0
Trifluoroacetic acid anhydride 100G | 407-25-0
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 (free base) | 5 MG
Thanatin TFA is an inducible cationic antimicrobial peptide (AMP) with a single-disulfide-bond-containing β-hairpin structure. It exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria, as well as various fungal species. This peptide functions by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption.
- Exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria.
- Effective against various species of fungi.
- Disrupts bacterial outer membrane.
- Potent inhibitory effect on NDM-1-producing E. coli and K. pneumoniae strains.
- Increases survival rates and decreases bacterial titers in infected mice.
- Rescues pathological damages in a dose-dependent manner in vivo.
Medchemexpress LLC CL2A (TFA) | 2616704-22-2 | 99.5% | 1176.24 | C50H79N9O16 | 5 MG
CL2A (TFA) is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker for use in antibody-drug conjugate construction. The TFA salt form improves handling and stability and is designed to release payloads under acidic conditions to produce a bystander effect.
- Cleavable linker enabling payload release under acidic conditions.
- PEG8 spacer and triazole moiety for increased solubility and stability.
- Designed for conjugation to antibody cysteine residues via disulfide linkage.
- Available in small research-scale packages for use in ADC development.
- Stable as a powder when stored sealed at 4°C; shipped at room temperature.
Medchemexpress LLC aStAx-35R TFA | 99.1% | 2392.86 | 1 MG
aStAx-35R TFA is a stapled peptide that functions as an antagonist of the nuclear form of β-catenin, thereby inhibiting Wnt signaling. It competitively prevents the binding of β-catenin to TCF4 and selectively induces growth inhibition in Wnt-dependent cancer cells.
- Directly targets and antagonizes the nuclear form of β-catenin.
- Effectively inhibits the Wnt signaling pathway.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition in cancer cells dependent on Wnt signaling.
Medchemexpress LLC Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | 95.5% | 514.51 | 1 MG
EZM0414 TFA is the TFA salt form of EZM0414, a potent, selective, and orally active inhibitor of SETD2. It is characterized by an IC50 of 18 nM in the SETD2 biochemical assay and 34 nM in the cellular assay. This compound is suitable for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, orally active inhibitor of SETD2
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines
- Inhibits tumor growth in NOD SCID mouse xenograft models
- Shows robust tumor growth regressions in t(4;14) multiple myeloma cell line-derived xenograft models
- Associated with reductions in intratumoral H3K36me3 levels
- Demonstrates high oral bioavailability in rats and mice
- Well-tolerated in animal studies