Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC 5-FAM-LL-37 TFA | 95.76% | 4851.56 (free acid) | 1 MG
5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37, a LL-37 peptide labeled with fluorescein. It retains the antibacterial and immunomodulatory activities of LL-37 by binding to the bacterial cell membrane, thereby destroying its integrity and demonstrating broad-spectrum antibacterial efficacy.
- Retains antibacterial and immunomodulatory activities
- Binds to bacterial cell membrane
- Demonstrates broad-spectrum antibacterial efficacy
Medchemexpress LLC Ecallantide (DX-88) trifluoroacetate | 00-00-0 | 7053.81 g/mol (free base) | C305H442N88O91S8 · xC2HF3O2 | 5 MG
Ecallantide TFA is a recombinant plasma kallikrein inhibitor supplied as the trifluoroacetate salt for research use. It inhibits kallikrein-mediated formation of bradykinin and is used in laboratory studies of angioedema and bradykinin-related pathways. Provided in defined small-scale packages for analytical and preclinical research; not for human use.
- Specific recombinant plasma kallikrein inhibitor.
- Trifluoroacetate salt formulation for stability and handling.
- Available in small, defined package sizes suitable for research.
- Characterized molecular weight and molecular formula provided.
- Intended for research use only; not for clinical or human use.
- Applicable to studies of bradykinin-mediated signaling and angioedema models.
Medchemexpress LLC Ppack TFA | 157379-44-7 | 99.8% | 5 MG
PPACK TFA is a potent, selective, and irreversible thrombin inhibitor supplied as the trifluoroacetate (TFA) salt. It is used as an anticoagulant alternative for blood gas and whole-blood electrolyte analyses and inhibits plasminogen activator (rt-PA) binding to plasma protease inhibitors.
- Irreversible thrombin inhibitor for anticoagulant applications.
- Supplied as the trifluoroacetate salt for stability and handling.
- High analytical purity (99.8%).
- Suitable for blood gas and whole-blood electrolyte analyses.
- Available in a 5 mg research-size vial.
- CAS number: 157379-44-7.
Medchemexpress LLC GRGDSPC TFA | 99.2% | 804.75 | 5 MG
GRGDSPC TFA is a 7-amino acid thiolated cell adhesion peptide. It is utilized in conjugation reactions with acrylated dextran to regulate the interactions of human mesenchymal stem cells (hMSCs) with photocrosslinkable hydrogels.
- Thiolated cell adhesion peptide
- Composed of 7 amino acids
- Regulates human mesenchymal stem cell interactions
- Suitable for research applications
Medchemexpress LLC Calcitonin, eel TFA | 99.9% | 3528.89 | 5 MG
Calcitonin, eel TFA is a thyroid hormone peptide that plays a role in regulating calcium homeostasis. It is frequently used in research concerning postmenopausal osteoporosis. In vitro studies show that Calcitonin, eel stimulates phosphoinositide hydrolysis and prolactin release in cultured anterior pituitary cells more effectively than salmon calcitonin. However, it does not inhibit prolactin release under conditions stimulated by thyrotropin releasing hormone (TRH).
- Contributes to the regulation of calcium homeostasis.
- Widely used in postmenopausal osteoporosis research.
- Effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis in vitro.
- Stimulates prolactin release in cultured anterior pituitary cells in vitro.
- High purity of 99.91%.
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 1 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels. It inhibits glutamate exocytosis and calcium influx induced by high potassium, and blocks the high potassium-induced release of serotonin and norepinephrine. This compound does not affect L-type or N-type calcium channels.
- Potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels
- Inhibits glutamate exocytosis and calcium influx induced by high potassium
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
eMolecules 407-25-0 | Trifluoroacetic anhydride | Chem-Impex | MFCD00000416 | 210.031 | C4F6O3 | 99.000 | FC(F)(F)C(=O)OC(=O)C(F)(F)F | 25g | 322127108
Trifluoroacetic anhydride | Chem-Impex | 407-25-0 | MFCD00000416 | 210.031 | C4F6O3 | 99.000 | FC(F)(F)C(=O)OC(=O)C(F)(F)F | 25g | 322127108
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 | 1 MG
Thanatin TFA is an inducible cationic antimicrobial peptide that exhibits broad-spectrum activity against both Gram-negative and Gram-positive bacteria, as well as various species of fungi. It operates by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption. It shows potent inhibitory effects on the growth of NDM-1-producing *E. coli* and *K. pneumoniae* strains.
- Inducible cationic antimicrobial peptide
- Broad-spectrum activity against Gram-negative and Gram-positive bacteria, and fungi
- Disrupts bacterial outer membrane
- Inhibits NDM-1-producing *E. coli* and *K. pneumoniae* strains
- Strongly cationic with a pI of 10.48
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES LC-MS TRIFLUOROACETIC ACID50ML
NC2952351 LC-MS TRIFLUOROACETIC ACID50ML
Medchemexpress LLC CPN-351 TFA | 912.11 (free base) | 5 MG
CPN-351 TFA, a pentapeptide, acts as a selective antagonist for human NMUR1, demonstrating a pA2 of 7.35. Its antagonistic effect on human NMUR1 is significantly higher, specifically 10 times greater, than its effect on NMUR2. This compound is suitable for application in inflammation research.
- Selective antagonist of human NMUR1.
- Pentapeptide compound.
- Antagonistic effect on human NMUR1 is 10 times higher than on NMUR2.
- Used in the study of inflammation.
Medchemexpress LLC Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection