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Filtered Search Results
Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 1 ML
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BI-0474 is a potent inhibitor of KRASG12C, exhibiting an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. This compound demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows promising anti-tumor efficacy in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- IC50 value of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
- Anti-proliferative activity against NCI-H358 cells with G12C mutation (EC50 26 nM)
- Anti-tumor activity in non-small cell lung cancer xenograft models
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Pfaltz & Bauer 1-Naphthol| 500G | 90-15-3
1-Naphthol| 500G | 90-15-3
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Medchemexpress LLC Fedratinib hydrochloride hydrate | 1374744-69-0 | 99.9% | 615.62 | 500 MG
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Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive, and orally active JAK2 inhibitor. It has IC50s of 3 nM for both JAK2 and JAK2V617F kinase. This compound exhibits 35-fold selectivity over JAK1 and 334-fold selectivity over JAK3. It induces cancer cell apoptosis and is being researched for its potential in treating myeloproliferative disorders.
- Potent, selective, ATP-competitive, and orally active JAK2 inhibitor
- Induces cancer cell apoptosis
- Potential for myeloproliferative disorders research
- Shows selectivity over JAK1 and JAK3
- Available in various quantities for research use
- Comes with data sheet, COA, SDS, and handling instructions
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Medchemexpress LLC Lurasidone (Hydrochloride) | 367514-88-3 | 99.65% | 529.14 | 500 MG
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Lurasidone (Hydrochloride) acts as an antagonist for dopamine D2 and 5-HT7 receptors, with IC50s of 1.68 nM and 0.495 nM, respectively. It also functions as a partial agonist for the 5-HT1A receptor, exhibiting an IC50 of 6.75 nM.
- Shows higher affinity for dopamine D2 and 5-HT2A receptors compared to other antipsychotics tested.
- Dose-dependently increases the DOPAC/dopamine ratio in both the frontal cortex and striatum, with a more pronounced effect on the frontal cortex at higher doses.
- Dose-dependently inhibits conditioned avoidance response (CAR) in rats.
- Dose-dependently inhibits TRY-induced forepaw clonic seizure and p-CAMP-induced hyperthermia.
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eMolecules 94749-08-3 | Medchem Express | Salmeterol (xinafoate) | 10mg | 446268457 | HY-17453 | MFCD00897708 | 603.756 | C36H45NO7
Medchem Express | Salmeterol (xinafoate) | 10mg | 446268457 | HY-17453 | 94749-08-3 | MFCD00897708 | 603.756 | C36H45NO7
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(CCCC)c1ccnc(SC)n1 | 500mg | 525920338](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502439938.PNG-250.jpg)
eMolecules 123061-49-4 | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | Synthonix - Stock | MFCD01319026 | 415.230 | C17H32N2SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(SC)n1 | 500mg | 525920338
2-(Methylthio)-4-(tributylstannyl)pyrimidine | Synthonix - Stock | 123061-49-4 | MFCD01319026 | 415.230 | C17H32N2SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(SC)n1 | 500mg | 525920338
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Aobchem AOBCHEM
5000862542 N-METHOXY-N-METHYL-1-NAPHTHALE
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Chem-Impex International, Inc. 1,2,3,4-Tetrahydro-1-naphthoic acid | 1914-65-4 | MFCD02179127 | 1G
1,2,3,4-Tetrahydro-1-naphthoic acid, 1914-65-4, MFCD02179127, 1G
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Apexbio Technology LLC Adapalene 106685-40-9 10mM (in 1mL DMSO)
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Adapalene (106685-40-9) is a small-molecule agonist targeting retinoic acid receptor subtypes RAR and RAR with lower affinity for RAR and minimal activity toward RXR It is designed to selectively modulate retinoic acid receptor-mediated gene transcription thereby regulating cellular growth differentiation and apoptosis Adapalene exerts its biological activity primarily through selective activation of RAR and RAR subtypes In experimental models adapalene exhibits agonistic activity with Ki values of 2 3 nM for RAR 9 3 nM for RAR and 22 nM for RAR Based on these pharmacological properties adapalene holds research potential in investigating retinoid signaling pathways cellular proliferation apoptosis and antitumor mechanisms particularly in colorectal cancer models
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000702363 NAPHTHOL AS-OL 100G
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![eMolecules 9001-62-1 | Sustine? 131 | Strem Chemicals238.201 | C11H9N3NaO2 | 0.000 | [Na+].OC1=CC(=O)C=C\C1=N\Nc1ccccn1 | 5g | 576207975](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215933.jpg-250.jpg)
eMolecules 9001-62-1 | Sustine? 131 | Strem Chemicals238.201 | C11H9N3NaO2 | 0.000 | [Na+].OC1=CC(=O)C=C\C1=N\Nc1ccccn1 | 5g | 576207975
Sustine? 131 | Strem Chemicals | 9001-62-1238.201 | C11H9N3NaO2 | 0.000 | [Na+].OC1=CC(=O)C=C\C1=N\Nc1ccccn1 | 5g | 576207975
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TARGETMOL CHEMICALS INC BI-69A11 25MG
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Also available in 1 mL, 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt. Purity 96.97%
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Medchemexpress LLC USP7-IN-10 hydrochloride | 99.3% | 549.51 | 1 MG
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USP7-IN-10 hydrochloride is a potent inhibitor of ubiquitin-specific protease 7 (USP7). It demonstrates an IC50 of 13.39 nM. This product is designed strictly for research applications.
- Functions as a potent USP7 inhibitor
- Exhibits an IC50 value of 13.39 nM
- Intended for research use only
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Medchemexpress LLC BI-749327 | 2361241-23-6 | 99.9% | 442.43 | 1 MG
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BI-749327 is a potent, highly selective, and orally bioavailable TRPC6 antagonist. It demonstrates significant selectivity, being 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7. In vitro, it suppresses NFAT activation and blocks signaling of prohypertrophic genes in isolated myocytes.
- Potent and selective TRPC6 antagonist
- Orally bioavailable
- Suppresses NFAT activation in HEK293T cells
- Blocks prohypertrophic gene expression in isolated myocytes
- Improves left heart function and reduces volume/mass ratio in vivo
- Reduces renal fibrosis in vivo
- Long terminal half-life in mice
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Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 100.0% | C17H19ClF3NO | 100 MG
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Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor. It exhibits potent inhibitory activity against human SERT (serotonin reuptake transporter) in HEK293 cells with an IC50 of 150 nM. This product is for research use only.
- Selective serotonin reuptake inhibitor
- Potent inhibitory activity against human SERT in HEK293 cells (IC50: 150 nM)
- Blocks downregulation of cell proliferation in hippocampal cells
- Increases newborn cells in the dentate gyrus of adult rat hippocampus
- Enhances neurogenesis-dependent long-term potentiation (LTP)
- Increases extracellular norepinephrine and dopamine levels in the prefrontal cortex
- Reverses escape latency deficits in rat models of inescapable shock
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