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Filtered Search Results
Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 25 MG
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BI-0474 is a potent KRASG12C inhibitor demonstrating significant activity against NCI-H358 cells with G12C mutations and anti-tumor effects in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- IC50 of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Demonstrates anti-tumor activity in non-small cell lung cancer xenograft models
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Selleck Chemical LLC DMNQ
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DMNQ is a 1 4-naphthoquinone that acts as a redox-cycling agent typically increasing intracellular superoxide and hydrogen peroxide formation
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Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 100.0% | C17H19ClF3NO | 500 MG
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Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor, intended for research use only.
- Acts as an antidepressant and selective serotonin reuptake inhibitor.
- Blocks downregulation of cell proliferation in hippocampal cells.
- Increases neurogenesis in the hippocampus and prelimbic cortex.
- Enhances neurogenesis-dependent long-term potentiation.
- Increases norepinephrine and dopamine extracellular levels.
- Reverses deficits in escape latency in animal models.
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Selleck Chemical LLC BI-4464
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BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK with an IC50 of 17 nM
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Aobchem AOBCHEM
5000862985 1 2-DIFLUORO-4- 2-PROPEN-1-YL
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Medchemexpress LLC (R)-1-(Naphthalen-1-yl)ethanamine hydrochloride | 82572-04-1 | 99.8% | C12H14CIN | 500 MG
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The (R)-1-(Naphthalen-1-yl)ethanamine hydrochloride is a chemical compound supplied as a white to off-white solid. With a high purity of 99.8% as confirmed by LCMS, this substance is suitable for various research and laboratory applications.
- White to off-white solid appearance
- Purity of 99.8% (LCMS)
- 1H NMR spectrum consistent with structure
- LCMS consistent with structure
- Store at 4°C under nitrogen
- Store in solvent at -80°C for 6 months or -20°C for 1 month under nitrogen
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Medchemexpress LLC KTX-582 | 2573298-13-0 | 98.7% | 872.93 | 1 MG
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KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. It can induce apoptosis in MYD88MT DLBCL and is efficient at inducing in vivo tumor regressions in a lymphoma model.
- Potent IRAK4 degrader
- Induces apoptosis in MYD88MT DLBCL
- Efficient at inducing in vivo tumor regressions in lymphoma models
- Degrades IRAK4 in whole blood monocyte and lymphocyte with IC50s of <0.05 μM
- Inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05-1 μM
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Ambeed AMBEED
5000868333 BIS3-NAPHTHALEN-1-YLPHEN 100MG
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Medchemexpress LLC BI-2493 | 2937344-16-4 | C24H27N7OS | 100 MG
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BI-2493 is a structural analogue of BI-2865, functioning as a highly selective and orally active pan-KRAS inhibitor. It is utilized in cancer research due to its ability to attenuate tumor growth.
- Highly selective and orally active pan-KRAS inhibitor
- Attenuates tumor growth
- Inhibits proliferation of KRAS mutant cancer cell lines
- Exhibits tumor-suppressive activity in xenograft models
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Selleck Chemical LLC CB-5339-5mg
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CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.
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eMolecules 105494-69-7 | 1-Methyl-2-(tributylstannyl)imidazole | Synthonix - Stock | MFCD01319030 | 371.156 | C16H32N2Sn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1nccn1C | 500mg | 525920331
1-Methyl-2-(tributylstannyl)imidazole | Synthonix - Stock | 105494-69-7 | MFCD01319030 | 371.156 | C16H32N2Sn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1nccn1C | 500mg | 525920331
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Medchemexpress LLC Lurasidone (Hydrochloride) | 367514-88-3 | 99.65% | 529.14 | 500 MG
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Lurasidone (Hydrochloride) acts as an antagonist for dopamine D2 and 5-HT7 receptors, with IC50s of 1.68 nM and 0.495 nM, respectively. It also functions as a partial agonist for the 5-HT1A receptor, exhibiting an IC50 of 6.75 nM.
- Shows higher affinity for dopamine D2 and 5-HT2A receptors compared to other antipsychotics tested.
- Dose-dependently increases the DOPAC/dopamine ratio in both the frontal cortex and striatum, with a more pronounced effect on the frontal cortex at higher doses.
- Dose-dependently inhibits conditioned avoidance response (CAR) in rats.
- Dose-dependently inhibits TRY-induced forepaw clonic seizure and p-CAMP-induced hyperthermia.
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Medchemexpress LLC Jbj-09-063 hydrochloride | 99.37% | 593.11 | 1 ML
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JBJ-09-063 hydrochloride is a mutant-selective allosteric EGFR inhibitor. It effectively reduces EGFR, Akt, and ERK1/2 phosphorylation and is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. This compound can be used for researching EGFR-mutant lung cancer.
- Mutant-selective allosteric EGFR inhibitor
- Effectively reduces EGFR, Akt, and ERK1/2 phosphorylation
- Effective across TKI-sensitive and resistant models
- Suitable for researching EGFR-mutant lung cancer
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eMolecules 82-75-7 | 8-Amino-1-naphthalenesulfonic acid | Apollo Scientific | MFCD00035730 | 223.250 | C10H9NO3S | 95.000 | Nc1cccc2cccc(c12)S(O)(=O)=O | 5g | 591806787
8-Amino-1-naphthalenesulfonic acid | Apollo Scientific | 82-75-7 | MFCD00035730 | 223.250 | C10H9NO3S | 95.000 | Nc1cccc2cccc(c12)S(O)(=O)=O | 5g | 591806787
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000596553 PROTOKYLOL HYDROCHL 1MG
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