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Filtered Search Results
Pfaltz & Bauer 1-CHLORONAPHTHALENE 90% 100ML
1-Chloronaphthalene 90%; 100ML CAS# 90-13-1
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Medchemexpress LLC Siglec-10 Human Bi 50ug | 50ug
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Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding preferentially selecting -2 3- or -2 6-linked sialic acid Its sialic acid recognition site may be masked by cis interactions Siglec-10 Protein Human (Biotinylated R119A HEK293 His-Avi) is the recombinant human-derived Siglec-10 protein expressed by HEK293 with C-Avi C-His labeled tag
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Medchemexpress LLC Siglec-10 Human Bi 50ug | 50ug
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Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding preferentially selecting -2 3- or -2 6-linked sialic acid Its sialic acid recognition site may be masked by cis interactions Siglec-10 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived Siglec-10 protein expressed by HEK293 with C-Avi C-His labeled tag
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Medchemexpress LLC Adapalene (CD271) | 106685-40-9 | 99.9% | C28H28O3 | 500 MG
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Adapalene (CD271) is a third-generation synthetic retinoid primarily used for acne research. It functions as a potent RAR agonist and non-competitively inhibits GOT1 enzymatic activity, also demonstrating anti-tumor properties.
- Acts as a potent RAR agonist with varying AC50s for RAR subtypes.
- Inhibits viability of various cancer cell lines.
- Induces apoptosis and inhibits proliferation in ES-2 cells.
- Increases G1-phase population in LoVo or DLD1 cells.
- Inhibits GOT1 activity.
- Inhibits expression of plasma membrane-associated enzyme transglutaminase Type I.
- Inhibits growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice, reducing tumor weight and volume.
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Medchemexpress LLC Mexiletine (hydrochloride) | 5370-01-4 | 99.9% | C11H18ClNO | 10 MM 1 ML
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Mexiletine is an orally effective antiarrhythmic agent also effective for myotonia and neuropathic pain. It blocks sodium channels and is used in cardiovascular and neurological research.
- Blocks sodium channels
- Effective for myotonia
- Effective for neuropathic pain
- Suitable for cardiovascular research
- Suitable for neurological research
- High purity (99.9%)
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Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 100 MG
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Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It exhibits inhibitory activity against PDE1 (IC50 of 180 nM) and PDE6 (IC50 of 11 nM), while its IC50s are greater than 1000 nM for PDE3 and PDE4. This compound functions by competitively inhibiting cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. It is utilized in research for applications related to erectile dysfunction, hepatitis, and diabetes.
- Selective and orally active PDE5 inhibitor
- Competitively inhibits cGMP hydrolysis
- Increases cGMP levels
- Useful for research on erectile dysfunction, hepatitis, and diabetes
- IC50 for PDE5: 0.7 nM
- IC50 for PDE6: 11 nM
- IC50 for PDE1: 180 nM
- IC50 for PDE3: >1000 nM
- IC50 for PDE4: >1000 nM
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Medchemexpress LLC MK-571 (sodium) | 115103-85-0 | 99.8% | 537.07 | 1 ML
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MK-571 sodium is an orally active, potent, and selective competitive leukotriene D4 (LTD4) receptor antagonist. It also acts as an inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1), and inhibits constitutive and antigen-stimulated sphingosine-1-phosphate (S1P) release.
- Potent and selective leukotriene D4 (LTD4) receptor antagonist.
- Inhibitor of multidrug resistance-associated protein MRP4 (ABCC4).
- Inhibitor of ABCC1 (MRP1).
- Inhibits constitutive and antigen-stimulated sphingosine-1-phosphate (S1P) release.
- Demonstrates activity in in vitro and in vivo studies.
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Medchemexpress LLC 2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyridinyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl]-, (1R,4R)- | 2769715-68-4 | 99.3% | 592.69 | 5 MG
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2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyridinyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl]-, (1R,4R)- | 2769715-68-4 | 99.3% | 592.69 | 5 MG
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Medchemexpress LLC Mexiletine hydrochloride | 5370-01-4 | 99.88% | 215.72 | 500 MG
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Mexiletine hydrochloride is an orally effective antiarrhythmic agent used for myotonia and neuropathic pain. It blocks sodium channels, making it suitable for cardiovascular and neurological research. This product is for research use only.
- Orally effective antiarrhythmic agent
- Effective for myotonia and neuropathic pain
- Blocks sodium channels
- Suitable for cardiovascular and neurological research
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Medchemexpress LLC 2-(2-chlorophenyl)-2-(5,7-dichloro-3-(hydroxymethyl)-4,6-dimethyl-1H-indol-2-yl)-N-((4-methylphenyl)su | 2244452-09-1 | 99.6% | 499.36 g/mol | C21H20Cl2N2O6S | 1MG
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BI-4924 is a potent, selective small-molecule inhibitor of phosphoglycerate dehydrogenase (PHGDH) used in biochemical and cellular research to probe serine biosynthesis and PHGDH-dependent metabolism. The compound is a hydroxymethylene-bearing carboxylic acid derivative (CAS 2244452-09-1) with characterized physicochemical and solubility properties.
- Potent PHGDH inhibition: IC50 = 3 nM.
- Disrupts serine biosynthesis in cells (IC50 ≈ 2.2 μM at 72 h).
- Chemical formula C21H20Cl2N2O6S; molecular weight 499.36 g/mol.
- High purity: 99.6% (reported by supplier).
- Form: powder; suitable for DMSO stock solutions.
- Solubility in vitro: DMSO 125 mg/mL (≈250 mM; ultrasonic recommended).
- In vivo formulations documented for multiple vehicles at ≥2.08 mg/mL.
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Medchemexpress LLC ACOLBIFENE HYDROCHL 25 mg
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ACOLBIFENE HYDROCHL 25MG
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eMolecules 1141-38-4 | Naphthalene-2,6-dicarboxylic acid | Synthonix | MFCD00004105 | 216.192 | C12H8O4 | 97.000 | OC(=O)c1ccc2cc(ccc2c1)C(O)=O | 100g | 779541442
Naphthalene-2,6-dicarboxylic acid | Synthonix | 1141-38-4 | MFCD00004105 | 216.192 | C12H8O4 | 97.000 | OC(=O)c1ccc2cc(ccc2c1)C(O)=O | 100g | 779541442
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Medchemexpress LLC Cevimeline hydrochloride (synonyms: AF102B hydrochloride) | 107220-28-0 | 98.7% | C10H18ClNOS | 1 ML
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Cevimeline hydrochloride is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. It stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. It can also cross the blood-brain barrier.
- Quinuclidine derivative of acetylcholine
- Selective and orally active muscarinic M1 and M3 receptor agonist
- Stimulates secretion by salivary glands
- Used as a sialogogue for xerostomia
- Can cross the blood-brain barrier
- For research use only
- Molecular weight: 235.77
- Appearance: white to off-white solid
- Soluble in H2O at concentrations ≥ 50 mg/mL
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Medchemexpress LLC Cinacalcet (hydrochloride) | 364782-34-3 | 100.0% | C22H23ClF3N | 100 MG
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Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of the calcium-sensing receptor (CaR), primarily utilized for the treatment of cardiovascular diseases. This high-purity compound is provided as a white to off-white solid, suitable for various research applications.
- Orally active, allosteric agonist of Ca receptor
- Used in cardiovascular disease treatment
- High purity of 100.0%
- Good solubility in various solvents
- Comprehensive documentation available
- For research use only
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Medchemexpress LLC Cysteamine (hydrochloride) | 156-57-0 | 99.3% | C2H8ClNS | 10 G
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Cysteamine (hydrochloride) is an orally active agent used for the treatment of nephropathic cystinosis and as an antioxidant. This compound is intended for research use only.
- Increases intracellular glutathione levels in cystinotic cells, restoring the altered redox state.
- Counteracts increased rates of apoptosis in cystinotic cells.
- Exhibits antioxidant properties by increasing glutathione production.
- Acts as an excellent scavenger of OH and HOCl, and reacts with H2O2.
- Increases the production of several heat shock proteins (HSP).
- Exerts a dose-dependent effect on doxorubicin-induced cancer cell death.
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