Phenanthrenes and derivatives
Chemscene ChemScene | (S)-TRIP | 250MG | CS-W020708 | 0.98 | 874948-63-7| MFCD10567009 | 752.96
ChemScene | (S)-TRIP | 250MG | CS-W020708 | 0.98 | 874948-63-7| MFCD10567009 | 752.96
Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 200 MG
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. It inhibits the growth of human cancer cell lines SKBR3 and SKOV3, which overexpress Hsp90 client protein Her2, leading to down-regulation of Her2 and induction of Hsp70. It also induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells.
- Potent inhibitor of Hsp90
- Binds to Hsp90 with an EC50 of 62 ± 29 nM
- Inhibits the growth of human cancer cell lines SKBR3 and SKOV3
- Causes down-regulation of Her2
- Induces Hsp70
- Induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells
- Significant reduction in tumor size in animal models
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-(3R,4S) | 1213777-80-0 | 99.9% | 348.39 g/mol | C22H20O4 | 5 MG
Triphen diol is a phenol diol small-molecule research compound (CAS 1213777-80-0) reported to induce apoptosis and inhibit proliferation in pancreatic cancer models. It has molecular formula C22H20O4, molecular weight 348.39 g/mol, and is supplied with high reported purity for use in in vitro and in vivo studies. Solubility and storage guidance is provided to support experimental workflows.
- Phenol diol small-molecule with reported anticancer activity.
- Demonstrated apoptosis induction and antiproliferative effects in pancreatic cancer cell lines.
- High reported purity suitable for biological assays.
- Soluble in DMSO at concentrations useful for stock preparations.
- Reported in vivo formulation options that yield clear solutions at ≥2.5 mg/mL.
- Storage recommendations provided to maintain stability during short- and long-term storage.
Cayman Chemical ArIstolochIc AcId C 10mg
An alkaloid; inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively)
Medchemexpress LLC Gabapentin hydrochloride | 60142-95-2 | >98.0% | C9H18ClNO2 | 200 MG
Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. It functions by inhibiting neuronal Ca2+ influx and reducing neurotransmitter release. This compound, which is a GABA analog, can be used to relieve neuropathic pain.
- It is a potent calcium channel blocker.
- It is orally active.
- Inhibits neuronal calcium influx.
- Reduces neurotransmitter release.
- It is a GABA analog.
- Can be used to relieve neuropathic pain.
Apexbio Technology LLC D-3-Phenyllactic acid 7326-19-4 200mg
D-3-Phenyllactic acid (CAS 7326-19-4) is a small-molecule inhibitor targeting specific Gram-positive and Gram-negative bacterial strains It is designed to disrupt microbial cell membrane integrity and interfere with related cellular metabolic pathways thereby inhibiting bacterial growth D-3-Phenyllactic acid exerts its biological activity primarily through disruption of microbial membranes and interference with cellular metabolism In in vitro studies D-3-Phenyllactic acid demonstrates inhibitory activity with reported IC50 values typically ranging between 10 50 g/mL depending on the target microorganism Based on these pharmacological properties D-3-Phenyllactic acid holds research potential in applications related to pathogen control in food safety and human health
Apexbio Technology LLC Kojic acid 501-30-4 200mg
Kojic acid (CAS 501-30-4) is a small-molecule inhibitor targeting tyrosinase a key enzyme involved in melanin biosynthesis It is designed to inhibit tyrosinase activity thereby reducing melanin production Kojic acid exerts its biological activity primarily through chelation of copper ions at the active site of tyrosinase In enzymatic assays on mushroom tyrosinase kojic acid demonstrates inhibitory activity with an IC50 typically ranging from 14 to 50 M Based on these pharmacological properties kojic acid holds research potential in hyperpigmentation disorders skin whitening applications and oxidative stress-related experimental models
Medchemexpress LLC Sch-1473759 hydrochloride | 1094067-13-6 | MFCD18251447 | 99.2% | 463.00 g/mol | C20H27ClN8OS | 200 MG
SCH-1473759 hydrochloride is a small-molecule dual aurora kinase inhibitor used in research to probe cell-cycle regulation and kinase signaling. It potently inhibits Aurora A and Aurora B at low nanomolar concentrations and displays activity against several related kinases.
- Potent dual Aurora A and B inhibition (IC50 = 4 nM and 13 nM).
- Direct binding to Aurora kinases (Kd ≈ 20-30 nM).
- Additional kinase activity including VEGFR2, Src family, Chk1, and IRAK4.
- High purity (≈99.2%) and solid, white to yellow physical form.
- Soluble in DMSO and water with warming; reported in vivo formulation options available.
- Suitable for cell-cycle and kinase signaling research applications.
- Recommended sealed storage; in solvent long-term storage at -80°C.
Medchemexpress LLC Piperidolate hydrochloride | 129-77-1 | 99.66% | 200 MG
Piperidolate hydrochloride is an antimuscarinic agent that inhibits intestinal cramps induced by acetylcholine in rats and dogs. This compound is intended for research use only.
- Antimuscarinic agent
- Inhibits intestinal cramps
- Research use only
- White to off-white solid appearance
Medchemexpress LLC Ivabradine hydrochloride | 148849-67-6 | 99.71% | 200 MG
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). It reduces heart rate in a dose-dependent manner without affecting blood pressure.
- Potent and orally active HCN channel blocker.
- Inhibits cardiac pacemaker current (If).
- Reduces heart rate dose-dependently without modifying blood pressure.
- Exhibits anticonvulsant, anti-ischaemic, and anti-anginal activity.
- Attenuates PTZ- and PICRO-induced seizures.
- Exhibits antioxidant effects in brain areas.
- Reduces cleaved caspase-3 expression.
Cayman Chemical ArIstolochIc AcId 10mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Cayman Chemical ArIstolochIc AcId 100mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas