Phenanthrenes and derivatives
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 25 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. It induces Bcr-Abl degradation in a ubiquitinproteasome-dependent manner and exhibits antiproliferative activity against K562 cells. It has the potential to study cancer.
- Induces Bcr-Abl degradation.
- Exhibits antiproliferative activity against K562 cells.
- Useful for cancer research.
- Features a 2-oxoethyl linker.
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 200 MG
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit. This compound induces cell apoptosis and demonstrates anti-cancer activity.
- Potent, orally active, selective, and ATP-competitive inhibitor.
- Targets colony stimulating factor 1 receptor (CSF1R) and c-Kit.
- Exhibits high selectivity over other related kinases.
- Induces cell apoptosis and demonstrates anti-cancer activity.
- IC50 of 10 nM for c-Kit and 20 nM for cFMS.
Medchemexpress LLC Crizotinib hydrochloride | 1415560-69-8 | 99.7% | C21H23Cl3FN5O | 200 MG
Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It also acts as a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition.
- Inhibits tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays
- Potently prevents cell proliferation by inducing G(1)-S-phase cell cycle arrest and apoptosis
- Causes marked regression of large established tumors in preclinical models
- Demonstrates a significant dose-dependent reduction of CD31-positive endothelial cells
- Leads to marked inhibition of phosphorylated c-Met, Akt, Erk, PLCλ1, and STAT5 levels
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.17% | 50 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It functions by recruiting the E3 ligase Von Hippel-Lindau, which leads to the ubiquitination and subsequent degradation of BCR-ABL1.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau.
- Induces ubiquitination and subsequent degradation of BCR-ABL1.
- Inhibits cell proliferation with IC50 values of 1.11 μM for WT cells, 1.98 μM for T315I cells, and 0.37 μM for G250E cells.
- Induces the degradation of c-ABL1.
- Inhibits downstream signaling through the STAT5 pathway in K562 and Ba/F3 cells.
Medchemexpress LLC Quinacrine dihydrochloride | 69-05-6 | MFCD00012659 | 99.4% | 472.88 | 200 MG
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is an orally bioavailable antimalarial agent with anticancer effects both in vitro and in vivo. It suppresses NF-κB and activates p53 signaling, leading to the induction of apoptosis. It is for research use only and not sold to patients.
- Orally bioavailable antimalarial agent
- Exhibits anticancer effects in vitro and in vivo
- Suppresses NF-κB and activates p53 signaling
- Induces apoptosis
- Increases proapoptotic proteins and decreases antiapoptotic proteins
- Suppresses circulating blast cells in AML models
- Increases median survival time in AML models
Sigma Aldrich Fine Chemicals Biosciences Triphenylene BCR(R), certified reference material | 217-59-4 | MFCD00001108 | 20MG
Triphenylene BCR(R), certified reference material | Mol Wt: 228.29 | 217-59-4 | MFCD00001108 | 20MG
Medchemexpress LLC Fullerene-C60 | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 | C60 | 5 MG
Fullerene-C60 is the C60 carbon allotrope used in photodynamic research, nanomaterials studies, and biochemical assays. This high-purity solid powder is provided for research applications and exhibits limited solubility in aqueous media.
- High purity (99.73%).
- Chemical formula C60 and molecular weight 720.64 g/mol.
- Solid powder appearance suitable for analytical and materials research.
- Low solubility in water (<0.1 mg/mL) and limited solubility in DMSO (<1 mg/mL).
- Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).
- Suitable for photodynamic and nanomaterials applications.
Crescent Chemical Co Inc 6-HYDROXY-CHRYSENE 10 MG
6-Hydroxy-chrysene Polycyc. arom. hydrocarb. (WS) CAS 37515-51-8 Molecular Weight - 244.2873 Storage - RT Catalog Num - DRE-E20990600 chemical
Electron Microscopy Sciences Rosin Alcohol Stock Solution 500 ML
Used in Wolbach's Giemsa Method Wolbach, Todd, and Palfrey (1922) Nuclei, collagen. References are Wolbach, S.B., Todd, J.L. and Palfrey, F.W., The Etilogy of Pathology Typhus, Harvard University Press, Cambridge, MA., p. 13 – 14,c 1922 and Luna, L.G., (ed), Manual of Histologic Staining Methods of the AFIP, 3rd Edition, McGraw-Hill, Y, p. 119, c. 1968
Sigma Aldrich Fine Chemicals Biosciences Carnosic acid from Rosmarinus officinalis >=91%, powder | 3650-09-7 | MFCD02259459 | 10MG
Carnosic acid from Rosmarinus officinalis >=91%, powder | Purity: >=91% | Mol Wt: 332.43 | 3650-09-7 | MFCD02259459 | 10MG
eMolecules Oakwood Chemical Malonic acid 1kg 537678614 020000 0 000 141-82-2 104 061 C3H4O4
Oakwood Chemical Malonic acid 1kg 537678614 020000 0 000 141-82-2 104 061 C3H4O4
eMolecules 2-Aminochrysene | 789-47-9 | MFCD00046286 | 1g
Combi-Blocks, Inc. | 2-Aminochrysene | 1g | 569291100 | HA-4398 | 95.000 | 789-47-9 | MFCD00046286 | 243.309 | C18H13N
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Crescent Chemical Co Inc CHRYSENE-D12 SOLN 1ML
Chrysene-d12 Single Component Calibration Standard in Dichloromethane CAS 1719-03-5 Size - 1mL Catalog Number - 3689D.10
Sigma Aldrich Fine Chemicals Biosciences Chrysene BCR(R), certified reference material | 218-01-9 | MFCD00003698 | 20MG
Chrysene BCR(R), certified reference material | Mol Wt: 228.29 | 218-01-9 | MFCD00003698 | 20MG
Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 200 MG
Irinotecan hydrochloride trihydrate is a potent topoisomerase I inhibitor known for its antitumor activity. It targets Topoisomerase I, playing a crucial role in cancer research and drug development.
- Inhibits the growth of LoVo and HT-29 cells.
- Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
- Significantly inhibits tumor growth in various in vivo models.
- Shows effectiveness against HT-29 xenografts.