Phenanthrenes and derivatives
Apexbio Technology LLC ARISTOLOCHIC-ACID-A-20MG
Aristolochic Acid A (CAS No 313-67-7) is a compound primarily explored in the field of toxicology and pharmacology Originating from the Aristolochiaceae family it is known for its role as a potent nephrotoxin and carcinogen making it a subject of interest in studies of renal toxicity and cancer research The compound acts by binding to DNA forming adducts that can lead to mutations particularly affecting pathways related to the cell cycle and apoptosis Its activity is typically observed in the nanomolar to low micromolar range Aristolochic Acid A is often used in vitro with various cell models such as renal epithelial cells and in vivo in animal models to understand its toxic effects and the mechanisms leading to tumorigenesis It is also employed in drug screening processes to identify potential inhibitors that may counter its detrimental effects Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Aristolochic acid B | 475-80-9 | 311.25 | 5 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts, is mutagenic, and exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Target: DNA alkylator/crosslinker
- Research area: Cancer
- Mechanism: Forms DNA adducts and is mutagenic
- Carcinogenic risk: Exhibits greater carcinogenic risk in vivo than Aristolochic acid I
- Appearance: Solid
- Melting/freezing point: 270-272°C
Apexbio Technology LLC Hypericin 548-04-9 10mg
Hypericin (CAS 548-04-9) is a small-molecule inhibitor targeting protein kinase C (PKC) and monoamine oxidase (MAO) It acts to selectively inhibit these enzymes thereby regulating cellular signal transduction pathways related to cell proliferation and apoptosis Hypericin exerts its biological activity primarily through selective inhibition of PKC In in vitro assays hypericin demonstrates an inhibitory profile with IC50 values against PKC ranging from approximately 100 to 250 nM depending on assay conditions Based on these pharmacological properties hypericin holds research potential in oncology virology and neuroscience
Aobchem 2-Bromotriphenylene | ≥95% | CAS 19111-87-6 | C18H11Br | 10g
2-Bromotriphenylene | ≥95% | CAS 19111-87-6 | C18H11Br | 10g
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 50 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be used in research on diseases related to the central nervous system (CNS). It inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This product is for research use only and not sold to patients.
- Inhibits ABL1 (64-515) with an IC50 of 8.7 nM.
- Can be used in research on diseases related to the central nervous system (CNS).
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
- Molecular weight is 359.30.
- Appears as a solid, white to off-white in color.
eMolecules 141-82-2 | Malonic acid | Key Organics/BIONET104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 5mg | 564178358
Malonic acid | Key Organics/BIONET | 141-82-2104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 5mg | 564178358
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | MFCD00069248 | >98.0% | 291.77 g/mol | C16H18ClNO2 | 200MG
SKF 38393 hydrochloride is the hydrochloride salt of SKF-38393, a selective dopamine D1 receptor agonist with a reported IC50 of approximately 110 nM. Supplied as a research-grade solid analytical standard, it is used for in vitro pharmacology, receptor binding, and analytical assays. Not for human or clinical use.
- Selective D1 receptor agonist, reported IC50 ≈ 110 nM.
- Hydrochloride salt form improves solubility for biological assays.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Provided as a solid analytical standard suitable for in vitro studies.
- Typical purities reported ≥98% by HPLC from third-party suppliers.
- Not for human or clinical use; for research only.
Apexbio Technology LLC VERATRIC-ACID-200MG
Veratric acid (CAS No 93-07-2) is a naturally occurring compound widely researched in the biomedical field particularly for its potential antioxidant properties Originating from various plant sources this compound exerts its effects primarily through the modulation of oxidative stress pathways It has demonstrated in vitro activity typically in the nanomolar to low micromolar range Veratric acid is frequently used in experimental settings including in vitro cell models and animal studies to assess its efficacy in mitigating oxidative damage It is also explored in drug screening processes for its potential protective effects against cellular damage Experimental concentrations typically depend on the specific research design