Unsubstituted Phenols
Medchemexpress LLC Isosilybin | 72581-71-6 | 482.44 | 50 MG
Isosilybin is a flavonoid derived from Silybum marianum that functions as an inhibitor of CYP3A4 induction. It is intended for research use only.
- Inhibits PXR-mediated CYP3A4 induction with an IC50 of 74 μM.
- Acts as a stronger inhibitor of PXR-mediated CYP3A4 induction compared to silybin.
- Exhibits anti-prostate cancer activity through cell cycle arrest and apoptosis induction.
- Increases phosphorylation of Akt and Mdm2, associated with androgen receptor degradation.
- Enhances the formation of a complex between Akt, Mdm2, and AR.
- Can significantly activate PPARγ and causes transactivation of a PPARγ-dependent luciferase reporter.
Medchemexpress LLC Liquiritin apioside | 74639-14-8 | 550.51 | 5 MG
Liquiritin apioside is an orally active inhibitor of the TRPV1 receptor, which selectively inhibits the laryngeal chemoreflex (LCR) without significantly affecting the mechanoreflex (LMR). It achieves this by attenuating reactive oxygen species (ROS) and NADPH oxidase, thereby weakening the interaction between ROS and TRPV1. This compound is valuable in research related to respiratory diseases and has shown potential in ameliorating colitis.
- Selectively inhibits laryngeal chemoreflex
- Does not significantly affect mechanoreflex
- Attenuates reactive oxygen species and NADPH oxidase
- Used in respiratory disease research
- Ameliorates DSS-induced colitis in mice
Medchemexpress LLC HY-19620 50mg , LMI070 NVS-SM1;Branaplam CAS:1562338-42-4 Purity:98%
Medchemexpress, HY-19620 50mg LMI070 NVS-SM1;Branaplam CAS:1562338-42-4 Formula:C22H27N5O2 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-50935 100mg , Troglitazone CS-045 CAS:97322-87-7 Purity:98%
Medchemexpress, HY-50935 100mg Troglitazone CS-045 CAS:97322-87-7 Formula:C24H27NO5S EC50: 550 nM (Human PPARγ), 780 nM (Murine PPARγ) Purity:98% Troglitazone is a PPARγ agonist, with EC 50 s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Miquelianin (Quercetin 3-O-glucuronide) | 22688-79-5 | 99.9% | 478.36 | 100 MG
Miquelianin (Quercetin 3-O-glucuronide) is a natural flavonoid and a metabolite of quercetin. It acts as a CBR1 inhibitor and is capable of crossing the blood-brain barrier.
- Metabolite of quercetin and natural flavonoid
- Functions as a CBR1 inhibitor
- Permeable to the blood-brain barrier
- Exhibits antioxidant effects in human plasma
- Reduces β-amyloid (Aβ) peptides generation
- Interferes with initial protein-protein interaction of Aβ1-40 and Aβ1-42
- Suppresses ROS generation and signaling pathways
- Inhibits invasion of breast cancer cells
- May act as a dietary chemopreventive factor
Medchemexpress LLC HY-10358 100mg , MK 2206 (dihydrochloride) CAS:1032350-13-2 Purity:98%
Medchemexpress, HY-10358 100mg MK 2206 (dihydrochloride) CAS:1032350-13-2 Formula:C25H23Cl2N5O IC50: 5 nM/12 nM/65 nM (Akt1/Akt2/Akt3) Purity:98% MK 2206 is an orally active allosteric Akt inhibitor with IC 50 of 5 nM/12 nM/65 nM for Akt1/Akt2/Akt3 , respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Isovitexin 2"-O-arabinoside | 53382-71-1 | 5 MG
Isovitexin 2''-O-arabinoside is a flavonoid found in plantlets of Avena sativa L. It increases alkaline phosphatase (ALP) activity and promotes BMP-2-induced osteoblast differentiation in C2C12 cells at concentrations from 0-10 μM over 3 days. It is for research use only.
- Flavonoid found in Avena sativa L. plantlets
- Increases alkaline phosphatase (ALP) activity
- Promotes BMP-2-induced osteoblast differentiation
- Targets phosphatase
- Involved in metabolic enzyme/protease pathway
Medchemexpress LLC Cardamonin | 18956-16-6 | MFCD00238554 | 98.4% | 270.28 g/mol | C16H14O4 | 10 MG
Cardamonin is a chalcone-class flavonoid research compound supplied for laboratory use. It is provided as a 10 mg pack (C16H14O4, 270.28 g/mol) and is commonly used in cell-based and biochemical studies involving inflammatory and cancer signaling pathways. For research use only.
- Purity of 98.4%.
- Chemical formula C16H14O4 and molecular weight 270.28 g/mol.
- Suitable for cell-based and biochemical assays.
- Provided as a 10 mg pack for laboratory use.
- Synonyms include cardamomin and alpinetin chalcone.
STA PHARMACEUTICAL US LLC Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid | 5 g | CAS 270063-49-5 | MDL MFCD01861045
Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid is a Amino Acid reagent (Subcategory: Beta AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 270063-49-5
- MDL: MFCD01861045
- InChIKey: UAGBOWBNDBDJMF-KRWDZBQOSA-N
- Molecular Weight: 470.346
- Molecular Formula: C25H21Cl2NO4
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4-dichlorophenyl)butanoic acid
- SMILES: ClC1=CC(Cl)=C(C[C@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)CC(O)=O)C=C1
Medchemexpress LLC Cl2a-sn-38 | 1279680-68-0 | 1480.61 | C73H97N11O22 | 50 MG
CL2A-SN-38 is a drug-linker conjugate composed of the DNA topoisomerase I inhibitor SN-38 linked via a hydrolyzable CL2A linker, intended for antibody-drug conjugate (ADC) research and development. It releases active SN-38 within tumor cells and the tumor microenvironment, producing bystander antitumor effects.
- Drug-linker conjugate designed for ADC development.
- Releases SN-38 within tumor cells and tumor microenvironment.
- Camptothecin-class topoisomerase I inhibitor mechanism.
- Molecular formula C73H97N11O22; molecular weight 1480.61.
- Soluble in DMSO (100 mg/mL) and in documented in vivo formulations.
- Store at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Sigma Aldrich Fine Chemicals Biosciences L-(-)-Norepinephrine (+)-bitartrate salt monohydrate meets USP testing specifications | 108341-18-0 | MFCD00150449 | 5G
L-(-)-Norepinephrine (+)-bitartrate salt monohydrate meets USP testing specifications | Mol Wt: 337.28 | 108341-18-0 | MFCD00150449 | 5G
Medchemexpress LLC Theaflavin-3-gallate | 30462-34-1 | MFCD29918450 | 99.9% | 716.60 g/mol | C36H28O16 | 10 MG
Theaflavin-3-gallate is a polyphenolic theaflavin monomer derived from black tea, supplied as a research-grade reagent for studies of apoptosis, oxidative stress, and DNA damage signaling. It acts as a pro-oxidant in some cancer cell models and can induce p53-dependent cell-cycle arrest and DNA damage via the ATM/Chk/p53 pathway.
- Purity 99.9%.
- Molecular weight 716.60 g/mol.
- Used to study apoptosis and p53-dependent mechanisms.
- Induces oxidative stress and DNA damage in cell-based assays.
- Available in small milligram sizes suitable for analytical work.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC Isosilybin A | 142796-21-2 | MFCD32182560 | 5 MG
Isosilybin A, a flavonolignan isolated from *Silybum marianum*, acts as a PPARγ agonist. It activates apoptotic pathways by targeting the Akt-NF-kB-AR axis and alleviates inflammatory responses in rosacea models through inhibition of Erk and p38 signaling. This compound also demonstrates anti-prostate cancer activity and is utilized in treating cirrhosis and hepatitis.
- PPARγ agonist that activates apoptotic pathways
- Relieves inflammatory responses by inhibiting Erk and p38 signaling
- Exhibits anti-prostate cancer activity
- Used in the treatment of cirrhosis and hepatitis
- Helps prevent the liver from exposure to toxic substances
- Suitable for HPLC and GC analytical techniques
Medchemexpress LLC Procyanidin A2 | 41743-41-3 | MFCD10566019 | 99.8% | 576.50 g/mol | C30H24O12 | 10 MG
Procyanidin A2 is a naturally occurring flavonoid dimer isolated from grapes and other plant sources, provided as a research-grade analytical reagent for laboratory and analytical applications. It is used as an analytical standard and in biochemical studies exploring antioxidant, antimicrobial, anti-inflammatory, and anti-cancer effects.
- High purity analytical standard suitable for research and analytical applications.
- Reported biological activities include antioxidant, antimicrobial, anti-inflammatory, and anti-cancer effects.
- Suitable for use in in vitro assays and analytical methods such as LC/MS.
- Well-characterized chemical identity: CAS 41743-41-3, formula C30H24O12, molecular weight 576.50 g/mol.
- Available in milligram-scale pack sizes for analytical workflows.