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Organic compounds that contain a carboxylic acid and a cyclopropane group; a cyclopropane group is a three-carbon ring. Includes compounds that are derived from cyclopropanecarboxylic acids.
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4-Hydroperoxy cyclophosphamide is the active metabolite of cyclophosphamide and is used as a research reagent to study DNA crosslinking, cytotoxic mechanisms, and immune-cell apoptosis. It is supplied as a dry solid for laboratory use and requires low-temperature storage to maintain stability in storage and handling.
active metabolite used in cytotoxicity and immunology studies.
cross-links DNA and induces T-cell apoptosis.
high purity: >98.0% (HPLC) as reported by analytical sources.
molecular weight 293.08 g/mol and formula C7H15Cl2N2O4P.
soluble in DMSO at 50 mg/mL; sonication may be required.
store at -20°C under nitrogen; in solvent store at -80°C for long-term stability.
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VH032-cyclopropane-F is a VHL E3 ligase ligand used as a building block for PROTAC design and for ligand-E3 ligase binding studies. It is supplied as a 10 mM solution in DMSO (1 mL) and as a solid powder, enabling direct use in assay development or conjugation chemistry.
Provided as 10 mM solution in DMSO (1 mL) and as powder.
Molecular weight 532.63.
Chemical formula C26H33FN4O5S.
Purity ≥95%.
Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Intended for use in PROTAC construction and E3 ligase binding studies.
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VH032-cyclopropane-F is a VH032-based von Hippel-Lindau (VHL) E3 ligase ligand used as the VHL-recruiting moiety in targeted protein degradation research (PROTACs). It is supplied as a solid research reagent with characterized physical and chemical properties and is designed for use in synthesis and biochemical assay development.
High purity reported (99.92%) for research applications.
Available in multiple small-scale pack sizes for synthesis and testing.
Stable as a powder at -20°C and in solvent under recommended storage conditions.
Molecular weight 532.63 and formula C26H33FN4O5S for unambiguous identification.
Intended for use as a VHL-recruiting building block in degrader design.
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4-hydroperoxy cyclophosphamide is the active metabolite of cyclophosphamide and functions as a DNA alkylator/crosslinker that induces T-cell apoptosis and produces reactive oxygen species. It is used as a research reagent to study DNA damage, apoptosis pathways, and immune modulation in vitro and in vivo.
Active DNA crosslinker inducing apoptosis independent of death-receptor activation.
Useful for studying apoptosis, immune cell depletion, and autoimmune disease models.
Supplied in small mass formats suitable for stock solution preparation, including 1 mg quantities.
Stable when stored under nitrogen at -20°C; in solvent stable at -80°C for up to 6 months.
High purity (≥98.0%) suitable for biochemical and cellular assays.
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VH032-cyclopropane-F is a VH032-based ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase used as a building block in PROTAC and E3 ligase research. The compound has molecular formula C26H33FN4O5S, molecular weight 532.63 g/mol, and CAS 2306193-99-5. It is provided as a research-grade small molecule; handle according to applicable safety data and laboratory practices.
VHL E3 ligase ligand suitable for PROTAC assembly.
Molecular formula C26H33FN4O5S and Mw 532.63 g/mol.
High purity (≥95.0%) appropriate for biochemical studies.
Solid material for dissolution in common organic solvents.
Intended for research use only; not for human or veterinary use.
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4-Hydroperoxy cyclophosphamide is the hydroperoxide derivative of cyclophosphamide supplied for in vitro research. It acts as a reactive alkylating agent and a source of activated cyclophosphamide metabolites for biochemical and cellular studies. Supplied as a solid, the material requires cold, inert storage and is for research use only, not for human or clinical applications.
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VH032-cyclopropane-F is a VH032-based von Hippel-Lindau (VHL) ligand used as an E3 ligase recruiter in PROTAC design and synthesis. The compound contains a functionalized cyclopropane terminus that facilitates conjugation to target ligands via linkers, enabling construction of bifunctional degraders and in vitro evaluation of VHL-mediated activity.
Used as an E3 ligase (VHL) ligand for PROTAC design and synthesis.
Molecular formula C26H33FN4O5S; molecular weight 532.63.
CAS number 2306193-99-5 for compound identification.
Soluble in DMSO at 100 mg/mL (requires ultrasonic) and formulatable for in vivo at ≥2.5 mg/mL in common vehicle systems.
Storage: powder at -20°C; in solvent at -80°C (6 months) or -20°C (1 month).
Purity typically ≥95% (supplier dependent).
Supplied in small research quantities such as 10 mg vials for synthetic applications.
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