Organic phosphoric acids and derivatives
AOBCHEM N N-diethyl-6-methylnicotinamide | 95% | CAS 50385-87-0 | C11H16N2O | 1g
N N-diethyl-6-methylnicotinamide | 95% | CAS 50385-87-0 | C11H16N2O | 1g
MEDCHEMEXPRESS LLC Glycerol-3-phosphate dehydrogenase, rabbit muscle | 9075-65-4 | 100-300 U/mg protein | 35,780 Da | 1 KU
Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. It functions as a glycolytic enzyme and is crucial for the re-oxidation of NADH to NAD+ and for energy supply. The product appears as a liquid, colorless to light yellow. It is intended for research use only.
- Catalyzes reversible redox conversion of dihydroxyacetone phosphate
- Crucial for re-oxidation of NADH to NAD+
- Important for energy supply
- Liquid, colorless to light yellow appearance
- For research use only
MEDCHEMEXPRESS LLC 2-propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)- | 18550-98-6 | 98.95% | 210.23 | 100 MG
3PO, also known as 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-, is a potent inhibitor of PFKFB3. This compound effectively attenuates the proliferation of various cancer cell lines by suppressing glucose uptake and reducing the intracellular concentrations of key metabolic intermediates like Fru-2,6-BP, lactate, ATP, NAD+, and NADH. It is commonly utilized in cancer research for its role in influencing cell cycle and inhibiting glycolytic flux.
- Inhibits PFKFB3, a key enzyme in glycolysis.
- Attenuates proliferation of multiple cancer cell lines.
- Suppresses cellular glucose uptake.
- Decreases intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
- Induces G2-M phase cell cycle arrest in certain cell types.
- Used extensively in cancer research studies.
- Demonstrates activity in both in vitro and in vivo models.
MEDCHEMEXPRESS LLC 3PO | 18550-98-6 | 99.9% | 210.23 | 1 ML
3PO is a light yellow to yellow solid and an inhibitor of PFKFB3. It attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. It can be used for the research of cancer.
- Solid appearance
- Purity of 99.85%
- Inhibitor of PFKFB3
- Attenuates proliferation of cancer cell lines
- Suppresses glucose uptake
- Decreases intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH
- Soluble in DMSO at 60 mg/mL