Azobenzenes

eMolecules​ AstaTech / 23-DIAMINOPHENAZINE / 1g / 323610682 / F15496 / 0.000 / 655-86-7 / MFCD00160693 / 210.240 / C12H10N4

AstaTech / 23-DIAMINOPHENAZINE / 1g / 323610682 / F15496 / 0.000 / 655-86-7 / MFCD00160693 / 210.240 / C12H10N4

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Medchemexpress LLC 3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one | 924377-85-5 | MFCD08868156 | 99.1% | 395.52 g/mol | C22H25N3O2S | 5 MG

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GSK1702934A is a small-molecule activator selective for TRPC3 and TRPC6 channels used as a research tool to probe TRPC-mediated calcium signaling. It induces TRPC3/6-dependent currents and has been applied to studies of cardiac contractility and arrhythmogenesis in cellular and tissue models. The compound is offered in solid form and as DMSO solution for experimental convenience.

• Selective TRPC3/6 activation for targeted functional studies.
• High purity suitable for biochemical and electrophysiology assays.
• Available as small solid quantities and as DMSO solution for convenience.
• Supports studies of cardiac contractility and arrhythmogenesis.
• Compatible with cellular assays and patch-clamp electrophysiology.

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eMolecules​ Ambeed / 1-(1112-Didehydrodibenz[bf]azocin-5(6H)-yl)ethanone / 250mg / 660581022 / A1495298 / / 1421353-86-7 / [null] / 247.297 / C17H13NO

Ambeed / 1-(1112-Didehydrodibenz[bf]azocin-5(6H)-yl)ethanone / 250mg / 660581022 / A1495298 / / 1421353-86-7 / [null] / 247.297 / C17H13NO

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Medchemexpress LLC Lupiwighteone | 104691-86-3 | 99.5% | 338.35 | C20H18O5 | 10 MG

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Lupiwighteone is an isoflavone research compound used as a biochemical probe for studies of antioxidant, antimicrobial, and anticancer activity. It induces caspase-dependent and -independent apoptosis in cancer cells through inhibition of the PI3K/Akt/mTOR pathway. The material is supplied as a small solid suitable for preparation of DMSO stocks and in vivo formulation.

• Isoflavone small molecule for in vitro and in vivo research.
• Induces apoptosis via PI3K/Akt/mTOR pathway inhibition.
• Solubility: DMSO 100 mg/mL (in vitro); ≥2.5 mg/mL in 10% DMSO/90% corn oil (in vivo).
• Storage: store at 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month).
• Key identifiers: CAS 104691-86-3; formula C20H18O5; molecular weight 338.35.

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eMolecules​ Medchem Express / GSK1702934A / 5mg / 533802300 / HY-111098 / / 924377-85-5 / MFCD08868156 / 395.520 / C22H25N3O2S

Medchem Express / GSK1702934A / 5mg / 533802300 / HY-111098 / / 924377-85-5 / MFCD08868156 / 395.520 / C22H25N3O2S

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Medchemexpress LLC MIND4-19 | 129544-85-0 | 99.93% | 373.47 | 100 MG

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MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease.

• Potent SIRT2 inhibitor.
• IC50 value of 7.0 μM for SIRT2.
• Can be used for researching Huntington's disease.

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Medchemexpress LLC MIND4-19 | 129544-85-0 | 99.9% | 373.47 | 5 MG

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MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. This compound is intended for use in researching Huntington's disease.

• Solid, white to off-white appearance
• Soluble in DMSO for in vitro applications
• Can be dissolved using various co-solvents for in vivo protocols
• Targeted for SIRT2 inhibition

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eMolecules​ Medchem Express / Fidarestat / 1mg / 489862920 / HY-105185 / / 136087-85-9 / MFCD00919183 / 279.227 / C12H10FN3O4

Medchem Express / Fidarestat / 1mg / 489862920 / HY-105185 / / 136087-85-9 / MFCD00919183 / 279.227 / C12H10FN3O4

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Medchemexpress LLC 5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one | 2133499-85-9 | MFCD32201069 | 99.7% | 264.30 g/mol | C13H12O4S | 10MG

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HSP27 inhibitor J2 is a small-molecule research reagent that targets heat shock protein 27 (HSP27), inducing abnormal HSP27 dimer formation and disrupting polymer assembly. It is provided as a solid and as a 10 mM solution in DMSO for biochemical and cellular studies; not for clinical use.

• Selective inhibitor of HSP27 for in vitro research.
• High purity: 99.7%.
• Molecular weight: 264.30 g/mol.
• Chemical formula: C13H12O4S.
• Available as solid and 10 mM solution in DMSO.
• Physical form: off-white to light yellow solid.
• Recommended storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.

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Medchemexpress LLC KG5 | 877874-85-6 | C20H16F3N7OS | 100 MG

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KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor, also inhibiting Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic activities.

• Inhibits vascular smooth muscle cells and endothelial cells viability
• Selectively blocks S338 phosphorylation
• Inhibits PDGFRα, PDGFRβ, Flt3, and KIT
• Prevents tumor growth in an orthotopic renal cell carcinoma model
• Completely blocks angiogenesis in mice
• Disrupts angiogenesis during zebrafish embryogenesis

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eMolecules​ Medchem Express / MIND4-19 / 5mg / 721434759 / HY-147233 / / 129544-85-0 / MFCD01614372 / 373.470 / C22H19N3OS

Medchem Express / MIND4-19 / 5mg / 721434759 / HY-147233 / / 129544-85-0 / MFCD01614372 / 373.470 / C22H19N3OS

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Medchemexpress LLC 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone | 274925-86-9 | MFCD09954136 | 99.9% | 273.24 | C14H11NO5 | 100 MG

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Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor provided as a high-purity research reagent for biochemical and pharmacological studies. It is characterized by known identifiers and physical properties, and is intended for laboratory research use only (not for human use).

• Reversible COMT inhibitor suitable for enzyme assays and pharmacology studies.
• High purity for analytical and experimental consistency.
• Well-characterized identifiers available (CAS, MFCD, InChIKey).
• Soluble in DMSO for preparation of concentrated stock solutions.
• Supplied in a measured 100 mg amount for small-scale experiments.

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Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML

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PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.

• Potent PRMT5 inhibitor.
• Exhibits anti-tumor activities.
• Low toxicity in normal cells.
• Strongly inhibits colony forming ability in PANC1 and HT29 cells.
• Inhibits NF-κB activation and its target gene expression.
• Decreases TNFα and IL8 expression.

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Medchemexpress LLC Rhodojaponin V | 37720-86-8 | MFCD01724481 | 1 MG

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Rhodojaponin V is a diterpenoid isolated from the leaves of *Rhododendron molle*. This compound exhibits anti-inflammatory activity and is identified as the C-14 acetylation product of Rhodojaponen III. It is intended for research use only.

• Diterpenoid compound
• Isolated from *Rhododendron molle*
• Exhibits anti-inflammatory activity
• C-14 acetylation product of Rhodojaponen III
• For research use only

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Medchemexpress LLC HSDVHK-NH2 | 848644-86-0 | 99.5% | 720.78 | 10 MG

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HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction. It has an IC50 of 1.74 μg/mL (2.414 pM) and shows strong antagonism against αvβ3-GRGDSP interaction. This compound inhibits HUVEC proliferation by inducing cell death through caspases activations, which is linked to increased p53 expression.

• Antagonist of integrin αvβ3-vitronectin interaction
• Inhibits bFGF-induced cell migration
• Shows strong antagonism against αvβ3-GRGDSP interaction
• Inhibits HUVEC proliferation
• Induces HUVEC cell death via caspases activations
• Mechanism related to increased p53 expression

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