Azolines
Medchemexpress LLC VH032 thiol | 2098836-54-3 | 490.64 | 1 MG
VH032 thiol (VHL ligand 6) is a VHL ligand that binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
- Binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes.
- Induces ubiquitination and subsequent proteasomal degradation of target proteins.
eMolecules 2360-22-7 | 1-Methyl-2-mercaptobenzimidazole | MFCD01788333 | 5g
Ambeed | (R)-4-((tert-Butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid | 250mg | 600846481 | A723762 | 55227-00-4 | MFCD00076930 | 261.274 | C11H19NO6
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Medchemexpress LLC 2-Amino-5-mercapto-1,3,4-thiadiazole | 2349-67-9 | 99.9% | 133.20 | 100 G
2-Amino-5-mercapto-1,3,4-thiadiazole is a biochemical reagent used as a biological material or organic compound for life science-related research. It is intended for research use only and is not sold to patients.
- Biochemical reagent
- Can be used as a biological material for life science-related research
- Can be used as an organic compound for life science-related research
Medchemexpress LLC 5-nitrobenzimidazole | 94-52-0 | 99.7% | 163.14 | 25 G
5-nitrobenzimidazole is a genotoxic nitro compound and a 6-aminopurine analogue. It exhibits a slight inhibitory effect on xanthine oxidase, making it suitable for research related to hyperuricemia.
- Genotoxic nitro compound
- 6-aminopurine analogue
- Slight inhibitory effect on xanthine oxidase
- Suitable for hyperuricemia research
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF488 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Green fluorescent CF488A has Ex/Em at 490/515 nm One labeling of 5-20 ug Nanobody Thiol per kit
Medchemexpress LLC VH032 thiol | 2098836-54-3 | >95.0% | 490.64 | 10 MG
VH032 thiol (VHL ligand 6) is a VHL ligand designed to bind to the pan-BET inhibitor JQ1 via a linker, forming a PROTAC. This product is intended for research use only and is not sold to patients.
- Target: Ligands for E3 Ligase
- Pathway: PROTAC
- IC50 & target: VHL
Medchemexpress LLC 3-Mercapto-1,2,4-triazole | 3179-31-5 | 98.0% | 101.13 | 250 G
1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent suitable for life science related research. It serves as a biological material or organic compound, intended for research use only and not for patient applications.
- Utilized in a study to design a surface enhanced Raman scattering based probe for fast and accurate detection of DNA markers.
Medchemexpress LLC 4,7,10,13-Tetraoxapentadecanoic acid, 15-mercapto-, 1,1-dimethylethyl ester | 564476-33-1 | 97.0% | C15H30O6S | 250 MG
Thiol-PEG4-Boc is a PEG-based PROTAC linker, appearing as a colorless to light yellow liquid. It is suitable for the synthesis of PROTACs and complies with given specifications.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Colorless to light yellow liquid appearance
- Complies with specifications
- Target: PROTAC linkers
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF647 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red fluorescent CF647 has Ex/Em at 650/665 nm One labeling of 5-20 ug Nanobody Thiol per kit
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]- | 1347750-82-6 | ≥95.0% | 238.30 | 1 G
Thiol-PEG3-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands joined by a linker; one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Appearance: Liquid
- Color: Colorless to light yellow
- Formula: C9H18O5S
- Purity: ≥95.0%
- Molecular weight: 238.30
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC 1H-Benzimidazole, 2-(2-pyridinyl)- | 1137-68-4 | 99.9% | 195.22 | 100 G
2-(2'-Pyridyl)benzimidazole is a potentially tridentate ligand capable of forming stable complexes with various transition metal ions. It can function as an anti-inflammatory agent and an inhibitor of *Escherichia coli* methionine aminopeptidase.
- Potentially tridentate ligand
- Forms stable complexes with various transition metal ions
- Can be used as an anti-inflammatory agent
- Functions as an inhibitor of *Escherichia coli* methionine aminopeptidase
- For research use only
eMolecules 75-66-1 | 2-Methyl-2-propanethiol | Oakwood Chemicals | MFCD00004857 | 90.180 | C4H10S | 99.000 | CC(C)(C)S | 25g | 480148923
2-Methyl-2-propanethiol | Oakwood Chemicals | 75-66-1 | MFCD00004857 | 90.180 | C4H10S | 99.000 | CC(C)(C)S | 25g | 480148923
Medchemexpress LLC DOTA-thiol | 865470-67-3 | MFCD11501203 | 98.9% | 463.55 g/mol | C18H33N5O7S | 10 MG
DOTA-Thiol is a bifunctional chelator - a macrocyclic DOTA derivative - intended for tumor pre-targeting and for conjugation to peptides and radionuclides. It contains a thiol functional group that enables site-specific attachment and is supplied at high purity for research applications.
- Bifunctional chelator with a reactive thiol group
- Enables conjugation of peptides and radionuclides
- Suitable for tumor pre-targeting and radiolabeling workflows
- High purity for research-grade use
- Available in milligram-scale pack sizes for synthesis and labeling
Medchemexpress LLC Methimazole-d3 | 1160932-07-9 | 99.7% | 1 MG
Methimazole-d3 is a deuterium labeled anti-thyroid agent, derived from Methimazole (Thiamazole), which blocks thyroid hormone production. Deuteration can impact the pharmacokinetic and metabolic profiles of drugs. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS