A serotonin synthesis inhibitor that is used for tracing pools of neuronal serotonin as a competitive inhibitor of tryptophan binding to albumin and as a substrate for the serotonin neural transporter
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A c-Met inhibitor (Ki 4 8 nM) 1000-fold selective for c-Met over a panel of 150 kinases inhibits the proliferation of and induces apoptosis in GTL-16 cells (IC50s 12 and 31 nM respectively) inhibits HGF-induced migration of H441 cells (IC50 11 nM) reduces tumor growth in a GTL-16 mouse xenograft model at 1-30 mg/kg
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A GPR52 antagonist (IC50 0 63 UM) reduces mHTT protein levels in STHdhQ7/Q111 cells in a concentration-dependent manner reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from HdhQ7/Q140 mice decreases striatal levels of soluble and insoluble mHTT as well as increases the latency to fall in the rotarod test in the HdhQ140 mouse model of Huntingtons disease at 5 mg/kg
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A serotonin synthesis inhibitor that is used for tracing pools of neuronal serotonin as a competitive inhibitor of tryptophan binding to albumin and as a substrate for the serotonin neural transporter
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An anticonvulsant inhibits the activation of Nav1 1 at 100 UM inhibits Nav1 1 but not Nav1 2 Nav1 3 and Nav1 6 opening and increases the action potential threshold in primary rat hippocampal neurons inhibits CAVA (Ki 343 8 nM) but not CAI and CAII (Kis 10000 nM for both) prolongs the preictal phase and reduces seizure-like event frequency in an in vitro model of epileptiform activity in rat hippocampal slices at 100 UM inhibits pentylenetetrazole-induced seizures in a mouse model of epilepsy (ED50 54 mg/kg i p ) reduces kainic acid-induced neuronal cell death in the mouse hippocampal CA3 region when used at doses of 25 50 and 100 mg/kg
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A selective inhibitor of PI3Ka (Ki 0 2 nM) is 133- 20- and 51-fold selective for PI3Ka over PI3KB PI3K and PI3KY respectively inhibits proliferation of MCF7-neo/HER2 and PC3 cells (EC50s 0 1 and 2 2 M respectively) induces tumor regression in a KPL-4 mouse xenograft model at 6 25 mg/kg reduces tumor growth tumor vasculature and the number of liver and lymph node metastases in the RIP1-Tag2 transgenic mouse model of pancreatic neuroendocrine tumors
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Preparation This antibody which contains a mouse IgG1 isoform was produced as a recombinant protein expressed in HEK293 cells using an engineered construct based on a monoclonal scavenger receptor B2/CD36 antibody Host HEK293 cells Species Reactivity ( ) Human mouse rat Cross Reactivity ( ) CD36 Applications FC
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Albendazole Oxide (CAS 54029-12-8) is a small-molecule inhibitor targeting beta-tubulin It is designed to inhibit beta-tubulin polymerization in parasites thereby disrupting cytoplasmic microtubule structure and interfering with glucose metabolic pathways Albendazole Oxide exerts its biological activity primarily through inhibition of beta-tubulin polymerization In both in vitro and in vivo studies Albendazole Oxide demonstrates anti-parasitic activity with reported IC50 values typically ranging from nanomolar to micromolar concentrations depending on the parasite species and assay system Based on these pharmacological properties Albendazole Oxide holds research potential in the exploration of anti-parasitic pharmacodynamics notably for studies involving Echinococcus spp and other parasitic infections
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Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic. Purity 98.04%
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