Benzoxazines
TARGETMOL CHEMICALS INC SAMOTOLISIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms DNA-PK and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm Solid Tumor COLON CANCER BREAST CANCER and Advanced Cancer among others. purity: 99%
TARGETMOL CHEMICALS INC TOLCAPONE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. purity: 99%
TARGETMOL CHEMICALS INC LTX-315 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. LTX-315 (Oncopore) the oncolytic peptide inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. purity: 99%
TARGETMOL CHEMICALS INC TASQUINIMOD 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts. purity: 99%
TARGETMOL CHEMICALS INC SGC-CBP30 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50 21/38 nM). purity: 99%
TARGETMOL CHEMICALS INC ENCORAFENIB 10MG
Also available in 1 mg 5 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity. purity: 99%
TARGETMOL CHEMICALS INC BEXAROTENE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). purity: 99%
TARGETMOL CHEMICALS INC SELUMETINIB 200MG
Also available in 25 mg 50 mg 100 mg 500 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Selumetinib (AZD6244) (AZD6244) is an effective specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50 14/10 nM). purity: 99%
TARGETMOL CHEMICALS INC ISOLIENSININE 20MG
Also available in 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Isoliensinine (Isoliensinin) a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. 2. Isoliensinine possesses an anti-proliferative effect which is related to the decrease of the overexpression of growth factors PDGF-beta bFGF proto-oncogene c-fos c-myc and hsp7. purity: 98%
TARGETMOL CHEMICALS INC TRAVOPROST 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist. purity: 99%
TARGETMOL CHEMICALS INC ALOXISTATIN 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets. purity: 99%
TARGETMOL CHEMICALS INC ML-SA5 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. purity: 100%
TARGETMOL CHEMICALS INC SR3335 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SR3335 (ML 176) is a selective inverse agonist of ROR(alpha) competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki 220 nM). purity: 99%
TARGETMOL CHEMICALS INC COPTISINE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway. 3. Coptisine is a potential anti-osteosarcoma drug candidate via exerting a strong anti-osteosarcoma effect with very low toxicity . 4. Coptisine with a high dosage could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression. 5. Coptisine suppresses adhesion migration and invasion of MDA-MB-231 breast cancer cells in vitro the down-regulation of MMP-9 in combination with the increase of TIMP-1 possibly contributing to the anti-metastatic function for breast cancer. purity: 99%
TARGETMOL CHEMICALS INC SARDOMOZIDE DIHYDROCHLOR 5MG
Also available in 1mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. Sardomozide dihydrochloride (CGP 48664 dihydrochloride) is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC IC50 = 5 nM). purity: 99%