Biotin and derivatives
Medchemexpress LLC Biotin methyl ester 500mg
Biotin methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.7 g/mol | C26H41N5O7S | 50 MG
Biotin-LC-LC-NHS is a long-chain N-hydroxysuccinimide (NHS) activated biotinylation reagent used to label proteins, antibodies, and small molecules. The LC-LC spacer reduces steric hindrance during conjugation, and the NHS ester reacts with primary amines to form stable amide bonds.
- Provides long-chain spacer (LC-LC) to reduce steric hindrance.
- Reactive NHS ester for amine-selective conjugation.
- Suitable for labeling antibodies and small molecules.
- Solid, white to light yellow appearance; store under inert gas and protect from light.
- Soluble in DMSO; follow recommended solvent and storage guidance.
Medchemexpress LLC Mal-PEG1-NHS ester | 1807518-72-4 | 310.26 g/mol | C13H14N2O7 | 1 G
Mal-PEG1-NHS ester is a PEG-based bifunctional linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. It is used for bioconjugation in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs), enabling selective thiol-to-amine coupling via maleimide and NHS chemistries.
- Bifunctional maleimide and NHS ester chemistry for thiol and amine coupling.
- PEG spacer increases solubility and reduces steric hindrance.
- Non-cleavable linker suitable for ADC and PROTAC synthesis.
- Available in multiple pack sizes, including 1 g for preparative use.
- Molecular weight 310.26 g/mol and formula C13H14N2O7.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202473.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 250 MG
Bis-PEG1-NHS ester is a short, non-cleavable polyethylene glycol (PEG) homobifunctional linker bearing N-hydroxysuccinimide (NHS) ester groups, supplied as a white to off-white solid for research use. It is designed for antibody-agent conjugation and other amine-targeted bioconjugation applications where a hydrophilic, short spacer is required.
- non-cleavable, homobifunctional PEG linker with NHS ester termini
- short 1-unit PEG spacer to increase hydrophilicity and solubility
- amine-reactive NHS esters for labeling primary amines on proteins and peptides
- supplied as a solid with recommended storage at -20°C for long term
- batch-specific purity reported by COA; suitable for research applications only
Medchemexpress LLC Bis-PEG10 N-hydroxysuccinimide ester | 2221949-02-4 | 95.0% | 752.76 g/mol | C32H52N2O18 | 50 MG
Bis-PEG10 N-hydroxysuccinimide ester is a bifunctional PEG10-based NHS ester linker used for conjugation chemistry. It features two NHS-reactive termini separated by a ten-unit polyethylene glycol spacer, enabling efficient amine coupling, increased aqueous solubility, and flexible linker geometry for targeted conjugate assembly.
- Two NHS ester reactive groups for amine coupling.
- Ten-unit PEG spacer for improved solubility and flexibility.
- Suitable for linker assembly in PROTAC and ADC synthesis.
- Typical purity 95.0%.
- Appearance: colorless to off-white oil.
- Storage: pure form, -20°C; in solvent, -80°C for long-term storage.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203833.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G
Bis-PEG2-NHS ester is a non-cleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC). It contains an N-hydroxysuccinimide (NHS) ester reactive group for efficient amine coupling and is supplied as a white to off-white solid.
- Non-cleavable two-unit PEG linker
- NHS-ester functional group for amine coupling
- High purity suitable for conjugation chemistry
- Available in multiple pack sizes, including 5 G
- Powder storage: -20°C for up to 3 years
Medchemexpress LLC Azido-PEG9-NHS ester | 2801772-87-0 | >98% | C25H44N4O13 | 50 MG
Azido-PEG9-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. For optimal stability, store in a tightly sealed container in a cool, well-ventilated area, away from direct sunlight and ignition sources.
- Can be used in the synthesis of PROTACs
- Features an Azide group for click chemistry applications
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
- Recommended storage at -20°C for up to 3 years in pure form
Medchemexpress LLC 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 1 G
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is a white to off-white solid and is intended for research use only.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- White to off-white solid appearance
- For research use only
Apexbio Technology LLC Azidobutyric acid NHS ester 50mg
Azidobutyric acid NHS ester is a chemical reagent used to introduce azide functional groups onto biomolecules containing primary amines It is designed to enable the covalent modification of proteins peptides or amino-modified nucleotides facilitating subsequent copper-catalyzed azide-alkyne click chemistry reactions Azidobutyric acid NHS ester exerts its utility by forming stable amide bonds with amino groups under mild aqueous conditions thus providing an azide handle for bioorthogonal labeling Based on these properties Azidobutyric acid NHS ester holds research potential in applications such as bioimaging flow cytometry protein profiling affinity purification and drug conjugation research
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 98.7% | 258.34 g·mol⁻¹ | C10H18N4O2S | 500 MG
Biotin hydrazide is a carbonyl-reactive biotinylation reagent used to label carbonyl-containing biomolecules. It reacts with aldehyde and ketone groups (for example, periodate-oxidized glycoproteins) to introduce a biotin tag for downstream detection, affinity capture, and streptavidin-based assays.
- Reacts with carbonyl groups for selective biotinylation.
- Enables streptavidin-based detection and affinity capture.
- High purity for reproducible biochemical assays.
- Available as solid and solution preparations for workflow flexibility.
- Suitable for protein labeling and probe-based detection applications.
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 98.7% | 258.34 | C10H18N4O2S | 250 MG
Biotin hydrazide is a carbonyl-reactive biotinylation reagent used to label carbonyl-containing biomolecules such as glycoproteins and glycolipids for detection, enrichment, or affinity-capture applications.
- Reacts selectively with carbonyl groups to introduce a biotin tag.
- Suitable for biotinylation of glycoproteins and glycolipids.
- High purity (98.7%) for consistent experimental results.
- Soluble in DMSO (6.6 mg/mL) and water (2 mg/mL) with ultrasonic assistance.
- Chemical formula C10H18N4O2S and molecular weight 258.34 g/mol.
- Store powder at -20°C for long-term stability; 4°C for shorter-term storage.
Medchemexpress LLC Biotin-VAD-FMK | 1135688-15-1 | ≥98.0% | 672.81 g/mol | C30H49FN6O8S | 10 MG
Biotin-VAD-FMK is a cell-permeable, irreversible, biotin-labeled caspase inhibitor used to detect and label active caspases in cell lysates. The FMK electrophile covalently modifies active caspase catalytic residues, and the biotin tag enables downstream capture or detection with streptavidin-based reagents. Common uses include activity profiling and affinity capture in apoptosis research.
- Detects and labels active caspases in cell lysates.
- Covalent binding via FMK electrophile for durable labeling.
- Biotin tag enables streptavidin-based capture or detection.
- Cell-permeable for use in intact cells and lysates.
- Suitable for pull-downs, western blotting, and activity profiling.
- Stable powder with recommended frozen storage for long-term retention.
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 g/mol | C16H20N2O8S2 | 10 MG
Bis-SS-C3-NHS ester is a cleavable disulfide-containing N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It reacts with primary amines to form stable amide bonds, and the internal disulfide provides a reducible linkage for intracellular payload release, making it suitable for antibody-drug conjugate synthesis and conjugation method development.
- Cleavable disulfide linker for controlled payload release
- N-hydroxysuccinimide (NHS) ester reactive toward primary amines
- High purity suitable for research-scale conjugation
- Available in multiple small-scale pack sizes for method development
- Stable when stored sealed at -20°C and protected from moisture
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 50 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups