Biotin and derivatives
Medchemexpress LLC Azido-PEG5-NHS ester | 1433996-86-1 | ≥98.0% | C17H28N4O9 | 25 MG
Azido-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in the synthesis of PROTACs.
Medchemexpress LLC 3aS 4S 6aR -Biotin- 100mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]
Apexbio Technology LLC NHS-SS-11-Biotin(Synonyms: Sulfo-NHS-SS-Biotin, EZ-Link NHS-SS-Biotin, NHS-SS-D-Biotin, N-Hydroxysuccinimidyl-SS-Biotin), 5mg, CAS: 142439-92-7.
NHS-SS-11-Biotin (CAS 142439-92-7) is an amine-reactive biotinylation reagent commonly used in biochemical research Structurally it possesses an N-hydroxysuccinimide (NHS) ester group that covalently reacts with primary amines of target proteins or biomolecules forming stable amide bonds and releasing sulfo-NHS This reagent features a cleavable disulfide linker and an extended spacer arm of approximately 24 3 enhancing probe accessibility to avidin or streptavidin conjugates It is utilized extensively for reversible biotinylation affinity purification or labeling studies in proteomics and cell biology applications
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | (C2H4O)nC7H9NO5 | 50 MG
M-PEG-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Protacs contain two different ligands connected by a linker
- Features a ligand for an E3 ubiquitin ligase and another for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bis-PEG9-NHS ester 5g | 1008402-79-6 | 708.71 | C30H48N2O17 | 5 G
Bis-PEG9-NHS ester is a homobifunctional PEG-based linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups, used to conjugate primary amines on proteins, peptides, and small molecules for research applications.
- Homobifunctional PEG9 spacer with two NHS ester reactive groups.
- Facilitates amine-directed bioconjugation to proteins and peptides.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- Suitable for PROTAC and ADC linker chemistry in research.
- High purity for reliable experimental performance.
TARGETMOL CHEMICALS INC Biotin-PEG12-NHS ester 50MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. Purity ≥98%
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 | C16H20N2O9 | 10 MG
Mal-PEG3-C1-NHS ester is a non-cleavable three-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester functional group, used to conjugate payloads to antibodies during antibody-drug conjugate synthesis. It is supplied as premeasured vials in DMSO to simplify dosing and handling in bioconjugation workflows.
- Non-cleavable three-unit PEG linker for bioconjugation.
- Maleimide reacts selectively with thiol groups; NHS ester reacts with primary amines.
- Supplied pre-dissolved in DMSO at 260.19 mM for convenient dosing.
- High purity suitable for research applications (95.0%).
- Colorless to light yellow solution stable at -20°C for up to 2 years when stored as directed.
Medchemexpress LLC BHQ-2 NHS | 916753-62-3 | 97.7% | 603.58 | 25 MG
BHQ-2 NHS is a dark quencher lacking native emission, attributed to its polyaromatic-azo backbone and a terminal NHS ester. It features a broad and intense quenching range from 560-670 nm, making it suitable as an acceptor in fluorescence resonance energy transfer (FRET) applications when used with orange to far-red emitting dyes. The NHS ester allows for labeling of primary amines (-NH2) found in proteins, amine-modified oligonucleotides, and other amine-containing molecules.
- Dark quencher with no native emission.
- Wide and intense quenching range (560-670 nm).
- Useful as an acceptor in FRET applications with orange to far-red emitting dyes.
- NHS ester allows labeling of primary amines in proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Medchemexpress LLC Sulfo-NHS-LC-LC-biotin | 194041-66-2 | 99.3% | 669.74 g/mol | C26H40N5NaO10S2 | 10 MG
Sulfo-NHS-LC-LC-Biotin is a water-soluble, amine-reactive biotinylation reagent that contains a sulfo-NHS ester joined to biotin via a long-chain spacer arm to reduce steric hindrance and improve labeling efficiency. It reacts selectively with primary amines to form stable amide bonds and is commonly used to label proteins on intact exosomes and cell surfaces.
- Water soluble sulfo-NHS ester for aqueous labeling.
- Long-chain spacer reduces steric hindrance and improves accessibility.
- Reacts selectively with primary amines to form stable amide bonds.
- Suitable for labeling proteins on intact exosomes and crowded surfaces.
- Provided as a small-quantity powder for convenient handling in research workflows.
Medchemexpress LLC Biotin-PEG-thiol (MW 2000) | 98.0% | 2000 (Average) | 100 MG
Biotin-PEG-Thiol (MW 2000) is an active compound. It is pegylated by binding to streptavidin or antibiotin with high affinity and specificity, allowing it to modify biomolecules, proteins, peptides, and other small molecule materials. This compound is widely used in the research of agent release and nano new materials.
- Purity: 98.0%
- Molecular weight: 2000 (Average)
- Target: Fluorescent dye
- Pathway: Others
- In vitro solubility: DMSO: 125 mg/mL (Need ultrasonic)
- Storage conditions: -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen).
Medchemexpress LLC (+)-Biotin-SLC | 1864003-57-5 | ≥97.0% | 250 MG
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands (E3 ubiquitin ligase and target protein) connected by a linker
- Exploits intracellular ubiquitin-proteasome system for target protein degradation
- For research use only
- Appearance: Solid
- Color: White to off-white
- Storage: 4°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month) under nitrogen
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 98.7% | 258.34 | C10H18N4O2S | 250 MG
Biotin hydrazide is a carbonyl-reactive biotinylation reagent used to label carbonyl-containing biomolecules such as glycoproteins and glycolipids for detection, enrichment, or affinity-capture applications.
- Reacts selectively with carbonyl groups to introduce a biotin tag.
- Suitable for biotinylation of glycoproteins and glycolipids.
- High purity (98.7%) for consistent experimental results.
- Soluble in DMSO (6.6 mg/mL) and water (2 mg/mL) with ultrasonic assistance.
- Chemical formula C10H18N4O2S and molecular weight 258.34 g/mol.
- Store powder at -20°C for long-term stability; 4°C for shorter-term storage.
Apexbio Technology LLC Sulfo-NHS-Biotin Kit (30-90 kDa) 3samples
Sulfo-NHS-Biotin Kit (30-90 kDa) is a biotinylation reagent set designed to introduce biotin molecules onto primary amines in proteins such as immunoglobulin G (IgG) The biotin molecules in this kit are activated ester derivatives (Sulfo-NHS-biotin) functioning through covalent conjugation reactions where the NHS ester group selectively reacts with primary amino groups (e g lysine residues and protein N-termini) on proteins After conjugation labeled proteins can be applied in biotin-streptavidin platforms for detection immunoassays protein immobilization and affinity purification This kit is optimized for proteins within the molecular weight range of 30-90 kDa accommodating 50-200 g protein per reaction and allows removal of excess biotin or interfering low-molecular-weight components using filtration-based purification for improved labeling quality and purity