Biotin and derivatives
Medchemexpress LLC (S,E)-TCO-NHS ester | 1610931-22-0 | MFCD24386372 | ≥98.0% | 267.28 g/mol | C13H17NO5 | 10 MG
TCO-NHS ester (axial) is a trans-cyclooctene N-hydroxysuccinimide ester used as an amine-reactive building block for bioorthogonal conjugation. It enables rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine partners and is suitable for labeling or modifying amine-containing small molecules and biomolecules in organic media. The reagent is supplied as a purified solid with supporting analytical documentation for research use.
- Amine-reactive NHS ester for efficient conjugation.
- Fast bioorthogonal iEDDA reactivity with tetrazines.
- Suitable for labeling and bioconjugation of biomolecules.
- High purity for reproducible experimental results.
- Analytical documentation available (SDS, COA, H-NMR).
Medchemexpress LLC NHS-SS-Ac | 2750799-11-0 | 95.0% | 337.37 | 25 MG
NHS-SS-Ac is an amine-reactive product synthesized from acetic acid. It is intended for research use only.
- Amine-reactive product
- Purity of 95.0%
- Colorless to light yellow oil
- Recommended storage for pure form: -20°C for 3 years or 4°C for 2 years
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 98.7% | 258.34 g/mol | C10H18N4O2S | 1 G
Biotin hydrazide is a carbonyl-reactive biotinylation reagent that forms hydrazone linkages with oxidized carbohydrates and other carbonyl groups. It is used to introduce a biotin tag for detection, affinity capture, and enrichment of labeled proteins and glycoconjugates in biochemical assays and proteomics workflows.
- Reacts selectively with aldehydes and ketones after oxidation.
- Enables streptavidin-based detection and affinity purification.
- Suitable for labeling glycoproteins following periodate oxidation.
- Supplied as a solid reagent for solution preparation and storage.
- High purity for reproducible analytical and preparative work.
Medchemexpress LLC Mal-PEG6-NHS ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 g/mol | C23H34N2O12 | 5 G
Mal-PEG6-NHS ester is a non-cleavable linker containing a maleimide reactive group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester for thiol and amine bioconjugation. Supplied as a solid with typical purity of 98.0%, it is used in antibody-drug conjugate and PROTAC linker synthesis and general bioconjugation workflows.
- Non-cleavable linker for stable bioconjugation.
- Maleimide group enables thiol-specific conjugation.
- NHS ester allows amine coupling.
- PEG6 spacer increases solubility and reduces aggregation.
- Typical purity 98.0%.
- Soluble in DMSO at 100 mg/mL; in vivo formulation protocols documented.
- Supplied as a 5 g pack for research use.
eMolecules 1353016-71-3 | DBCO-NHS ester | Chem-Impex | MFCD24386367 | 402.406 | C23H18N2O5 | 97.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 5mg | 490843457
DBCO-NHS ester | Chem-Impex | 1353016-71-3 | MFCD24386367 | 402.406 | C23H18N2O5 | 97.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 5mg | 490843457
Apexbio Technology LLC DMG-PEG2000-NHS(Synonyms: DMG-PEG2000-NHS ester, NHS-PEG2000-DMG, DMG PEG NHS ester), 500mg.
DMG-PEG2000-NHS is a polyethylene glycol (PEG) derivative functionalized with an N-hydroxysuccinimide (NHS) ester The reactive NHS ester readily forms stable amide linkages upon interaction with primary amine (-NH ) groups facilitating covalent attachment to peptides proteins or amino-functionalized small molecules Due to these conjugation properties DMG-PEG2000-NHS is commonly employed in biomedical research for constructing drug delivery platforms such as lipid nanoparticles (LNPs) or liposomes particularly for siRNA delivery systems
Medchemexpress LLC Methoxy polyethylene glycol N-hydroxysuccinimide ester | 92451-01-9 | 98.0% | 10MG
Methoxy polyethylene glycol N-hydroxysuccinimide ester, average molecular weight 20,000 Da, is an NHS-activated methoxy-PEG reagent that reacts efficiently with primary amines to form stable amide bonds. It is supplied as a solid for research use and is commonly used for PEGylation of peptides and proteins, linker construction in targeted degraders, and general bioconjugation to improve solubility and pharmacokinetic properties.
- Reacts with primary amines to form stable amide linkages.
- Improves solubility and reduces immunogenicity of conjugates.
- Provides a 20 kDa hydrophilic spacer for linker design.
- Supplied as a high-purity reagent suitable for research applications.
- Compatible with standard coupling and purification workflows.
Chem-Impex International, Inc. Biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt | 127062-22-0 | MFCD00078534 | 100MG
Biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt, 127062-22-0, MFCD00078534, 100MG
Medchemexpress LLC Nsp-sa-nhs | 199293-83-9 | 99.7% | 681.73 | C32H31N3O10S2 | 10 MG
Acridinium ester reagent for chemiluminescent labeling in immunoassays. It is provided as a high-purity solid for research use and is intended to enable sensitive detection when conjugated to analytes in chemiluminescent assay workflows.
- Used for chemiluminescent immunoassay labeling.
- High purity (≈99.7%) for sensitive detection.
- Molecular weight 681.73 g·mol-1 and formula C32H31N3O10S2.
- CAS number 199293-83-9 for unambiguous identification.
- Supplied in milligram quantities suitable for conjugation workflows.
- Store sealed, protected from moisture and light, preferably at -20°C.
Medchemexpress LLC Biotin-C4-amide-C5-NH2 | 151294-96-1 | 97.0% | 314.45 | C14H26N4O2S | 100 MG
Biotin-C4-amide-C5-NH2 is a biotin-based, cleavable linker used to attach cytotoxins to antibodies in the synthesis of antibody-drug conjugates (ADCs). It is supplied as a solid with specified purity and storage instructions for research applications.
- Cleavable ADC linker suitable for ADC construction and biotin labeling.
- Solid, white to off-white appearance.
- Molecular weight 314.45 and formula C14H26N4O2S.
- Purity 97.0%.
- Available in multiple pack sizes, including 100 MG.
- Storage: store at 4°C protected from light; in solution keep at -80°C up to 6 months or -20°C up to 1 month.
TARGETMOL CHEMICALS INC Biotin-azide 5MG
Also available in 1 mL, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Biotin-azide (N-(3-Azidopropyl)biotinamide) is used for preparing various biotin affixes and identifying proteins. Purity 99.69%
Medchemexpress LLC NHS-MMAF | 1404073-19-3 | 97.2% | 943.18 | C49H78N6O12 | 5 MG
NHS-MMAF is an NHS-activated derivative of monomethyl auristatin F (MMAF) designed as a linkerable payload for antibody-drug conjugate research. It acts as a tubulin polymerization inhibitor and is supplied as a solid for laboratory research use.
- High purity suitable for research applications.
- Contains NHS ester for conjugation to amines.
- Potent tubulin polymerization inhibitor.
- Soluble in DMSO; requires ultrasonic treatment and freshly opened DMSO.
- Supplied as a solid; store at -20°C, protect from moisture and light.
Medchemexpress LLC Azido-PEG5-NHS ester | 1433996-86-1 | ≥98.0% | C17H28N4O9 | 50 MG
Azido-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups, leveraging the ubiquitin-proteasome system for selective protein degradation.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables targeted protein degradation
Medchemexpress LLC Norbornene-NHS | 1888335-48-5 | C12H13NO5 | 5 MG
Norbornene-NHS is a click chemistry reagent that functions as a dienophile for conjugation via copper-free Click reaction with tetrazines. This product is for research use only.
- Functions as a dienophile for conjugation
- Utilizes copper-free Click reaction
- Reacts with tetrazines