Cycloheptathiophenes
![Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-40106-13-6.jpg-250.jpg)
Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%
CAS: 40106-13-6 Molecular Formula: C12H17NO2S Molecular Weight (g/mol): 239.333 MDL Number: MFCD00216932 InChI Key: XTUHIGALMIGZST-UHFFFAOYSA-N Synonym: ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-4h,5h,6h,7h,8h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta-b thiophene-3-carboxylate,ethyl 2-amino-4,5,6,7,8-pentahydrocyclohepta 1,2-b thiophene-3-carboxylate,2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylic acid ethyl ester,ethyl 2-aminocyclohepta b thiophene-3-carboxylate,aronis24232,ethyl 2-aminocycloheptathiophene-3-carboxylate,2-amino-3-ethoxy-carbonyl-4,5-pentamethylenethiophene PubChem CID: 292644 IUPAC Name: ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate SMILES: CCOC(=O)C1=C(SC2=C1CCCCC2)N
Ketotifen fumarate, 99%
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Ketotifen Hydrogen Fumarate, EP, 98.5-101%, Spectrum™ Chemical
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.50 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N IUPAC Name: (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one SMILES: OC(=O)\C=C\C(O)=O.CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12
Ketotifen Fumarate 98.0+%, TCI America™
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Pizotifen 98.0+%, TCI America™
CAS: 15574-96-6 Molecular Formula: C19H21NS Molecular Weight (g/mol): 295.444 MDL Number: MFCD00864192 InChI Key: FIADGNVRKBPQEU-UHFFFAOYSA-N Synonym: 4-[9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene]-1-methylpiperidine, Sandomigran PubChem CID: 27400 ChEBI: CHEBI:50212 IUPAC Name: 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine SMILES: CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
Medchemexpress LLC Diethyl fumarate | 623-91-6 | 99.0% | 172.18 | 10 G
Diethyl fumarate is a decomposition product of Malathion 9 and a reactant in the Diels-Alder reaction. It is a reputed skin irritant and can cause non-immunologic contact urticaria on the skin. Diethyl fumarate and Curcumin hybridize to exert neuroprotective effects.
- Decomposition product of Malathion 9.
- Reactant in Diels-Alder reaction.
- Causes dose-dependent swelling of ears in guinea pigs.
- Curcumin hybrids show neuroprotective effects in C. elegans model of PD.
- For research use only.
Medchemexpress LLC Cevipabulin fumarate | 849550-67-0 | 99.9% | 580.89 | 50 MG
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines.
- Microtubule-active, antitumor compound
- Shows good activity (18-40 nM IC50 values) on ovarian, breast, prostate, and cervical tumor cell lines
- Produces sub-G1 nuclei at low concentrations (20-40 nM)
- Causes a strong G2-M block at concentrations above 50 nM
- Active via intravenous (i.v.) and oral (p.o.) administration against human tumor xenografts in mice, with good antitumor activity at 20 and 15 mg/kg
Enzo Life Sciences Ketotifen. fumarate (1g). CAS: 34580-14-8
Selective histamine H1 antagonist. Inhibits histamine release from monocytes and lymphocytes at 0.1-10 µM. Purity: ≥98% (HPLC). Solubility: Soluble in water (10 mg/ml). Long Term Storage: Ambient.
Medchemexpress LLC Fesoterodine fumarate | 286930-03-8 | 99.5% | C30H41NO7 | 10 MM * 1 ML
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It has pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. It is used for the treatment of overactive bladder (OAB).
- Decreases micturition frequency, urgency severity, and urgency incontinence episodes.
- Increases the volume voided with each micturition.
- Rapidly and extensively hydrolyzed in plasma to Desfesoterodine (an active metabolite of Fesoterodine) after oral administration.
- Reduces micturition pressure.
- Increases bladder capacity and intercontraction intervals (ICIs) at a dose of 0.01 mg/kg in bladders from female Sprague-Dawley rats.
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 50mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC Bedaquiline fumarate | 845533-86-0 | 99.99% | 671.58 | 5 MG
Bedaquiline fumarate is a diarylquinoline antibiotic that targets ATP synthase and is effective for the treatment of Mycobacterium tuberculosis infections.
- Inhibits the growth of TDR Mycobacterium tuberculosis strains.
- Highest activity against Mycobacterium avium among slowly growing mycobacteria.
- Shows moderate in vitro activity against NTM species.
- Excellent in vitro activity against multidrug-resistant Mycobacterium tuberculosis.
Apexbio Technology LLC Ibutilide Fumarate 122647-32-9 100mg
Ibutilide Fumarate (CAS 122647-32-9) is a small molecule classified as a Class III antiarrhythmic agent It acts primarily by enhancing slow inward sodium currents and delaying repolarization through inhibition of the rapid component of the cardiac delayed rectifier potassium current (IKr) resulting in prolongation of the cardiac action potential Ibutilide is utilized in research to investigate pharmacological cardioversion of atrial arrhythmias specifically studying the acute conversion of atrial fibrillation and atrial flutter to normal sinus rhythm Its properties make it valuable for exploring the mechanisms of antiarrhythmic therapy and cardiac electrophysiology
Medchemexpress LLC Ro60-0175 fumarate | 169675-09-6 | MFCD06798313 | 99.5% | 342.75 g/mol | C15H16ClFN2O4 | 1 ML
Ro60-0175 fumarate is a selective agonist of the serotonin 5-HT2C receptor used in neuroscience and pharmacology research. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid quantities; reported purity is 99.47%, with molecular formula C15H16ClFN2O4 and molecular weight 342.75 g/mol.
- Selective 5-HT2C receptor agonist for pharmacology studies.
- Available as 10 mM solution in DMSO (1 mL) and as solids (5, 10, 50 mg).
- High purity (~99.5%) suitable for research applications.
- Soluble in DMSO; in vitro solubility approximately 100 mg/mL.
- Storage guidance provided for powder and solutions to preserve stability.
Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.
- Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
- Active against ovarian, breast, prostate, and cervical tumor cell lines.
- Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
- Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
- Active in vivo via i.v. and p.o. administration against human tumor xenografts.
- Shows dose-dependent antitumor activity in mouse xenograft models.