Furans
Medchemexpress LLC Evixapodlin | 2374856-75-2 | 98.1% | C34H36Cl2N8O4 | 10MG
Evixapodlin is an orally bioavailable small-molecule inhibitor of programmed death-ligand 1 (PD-L1) used in research to modulate PD-1/PD-L1 protein-protein interactions. It has demonstrated potent activity in preclinical assays and has been evaluated in early clinical studies for advanced solid tumors.
- Chemical name: Evixapodlin.
- CAS number: 2374856-75-2.
- Molecular formula: C34H36Cl2N8O4.
- Molecular weight: 691.61.
- Reported IC50: 0.213 nM (PD-1/PD-L1 protein-protein interaction).
- Purity: 98.1% (HPLC).
- Physical form: powder for research use.
- Typical use: reagent for PD-1/PD-L1 pathway and oncology research.
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.9% | C27H43Cl3N4O5 | 10MG
JQKD82 trihydrochloride is a cell-permeable, selective inhibitor of lysine demethylase KDM5 (JARID1) used in epigenetic research. It increases histone H3 lysine 4 trimethylation (H3K4me3) and is applied in studies of multiple myeloma and KDM5-mediated regulation.
- Selective KDM5 inhibitor.
- Cell-permeable small molecule for intracellular studies.
- Increases H3K4me3 levels in treated cells.
- Supplied as the trihydrochloride salt for enhanced stability.
- High purity suitable for research use (99.9%).
- Available in multiple milligram pack sizes for assay flexibility.
eMolecules 5638-76-6 | 2-(2-Methylaminoethyl)pyridine | Combi-Blocks | MFCD00006362 | 136.198 | C8H12N2 | 97.000 | CNCCc1ccccn1 | 25g | 457916687
2-(2-Methylaminoethyl)pyridine | Combi-Blocks | 5638-76-6 | MFCD00006362 | 136.198 | C8H12N2 | 97.000 | CNCCc1ccccn1 | 25g | 457916687
Medchemexpress LLC PF-06456384 trihydrochloride | 1834610-75-1 | ≥98.0% | 829.18 g·mol⁻¹ | C35H32F3N7O3S2 · 3HCl | 25 MG
The trihydrochloride salt is a small-molecule research compound described as a highly potent and selective inhibitor of the NaV1.7 voltage-gated sodium channel; it has reported sub-nanomolar activity and is used in preclinical pain model research.
- Highly potent and selective NaV1.7 inhibition (reported IC50 ≈ 0.01 nM).
- Used in preclinical pain models, including the formalin test.
- Supplied as a trihydrochloride salt in white to beige powder form.
- High purity (≥98% by HPLC reported by distributors).
- Solubility: readily soluble in DMSO (~125 mg/mL); limited aqueous solubility (~2 mg/mL reported).
![Medchemexpress LLC 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone | 881639-98-1 | MFCD16618392 | 99.8% | 412.28 | C21H18BrNO3 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239727.png-250.jpg)
Medchemexpress LLC 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone | 881639-98-1 | MFCD16618392 | 99.8% | 412.28 | C21H18BrNO3 | 100 MG
G-1 is a nonsteroidal, high-affinity, selective agonist of the GPR30 (GPER) receptor used as a research reagent to probe estrogen-related signaling. The compound is supplied as a powdered research chemical with reported molecular weight 412.28 and CAS number 881639-98-1; solubility and storage recommendations are provided for laboratory handling.
- High-affinity GPR30 (GPER) agonist with Ki = 11 nM.
- Supplied as a stable powder for laboratory use.
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Recommended storage conditions for powder and solutions are provided.
- Useful for estrogen-related signaling and receptor pharmacology studies.
Medchemexpress LLC 7-tfa-ap-7-deaza-da | 178420-75-2 | 98.8% | C16H16F3N5O4 | 10MG
7-TFA-ap-7-Deaza-dA is a modified deoxynucleoside bearing a trifluoroacetyl-protected alkyne; designed for incorporation into DNA/oligonucleotides and for conjugation via copper-catalyzed azide-alkyne cycloaddition. Supplied as a solid or as a DMSO solution for use in synthetic and analytical workflows requiring a terminal alkyne handle.
- Contains an alkyne functional group for CuAAC click chemistry.
- Suitable for incorporation into deoxyribonucleic acid and oligonucleotide synthesis.
- Available as a solid and as a 10 mM solution in DMSO.
- High purity (~98.8%) suitable for research applications.
- Store solids at 4°C sealed; store solutions at low temperatures to preserve stability.
Medchemexpress LLC CCT365623 hydrochloride | 2126136-98-7 | 98.1% | 443.99 g·mol⁻¹ | C18H18ClNO4S3 | 50MG
CCT365623 hydrochloride is the hydrochloride salt of a small-molecule lysyl oxidase (LOX) inhibitor intended for research use. It exhibits LOX inhibitory activity in the submicromolar to low-micromolar range, suppresses EGF-driven EGFR (pY1068) and AKT phosphorylation in cellular studies, and has reported favorable pharmacokinetic properties.
- Hydrochloride salt form for improved solubility.
- Reported LOX inhibitory activity with IC50 ≈ 0.89 μM.
- Suppresses EGF-driven EGFR (pY1068) and AKT phosphorylation in cell-based assays.
- High reported purity (~98.1%).
- Available as solid vials and as solution formulations in DMSO.
- For research use only.
AdipoGen 2 7-Dichlorofluorescin DA
Chemical. CAS 4091-99-0. Formula C24H16Cl2O7. MW 487.29. Dichlorofluorescin diacetate H2DCFDA is a chemically reduced analog of fluorescein, used as an indicator for reactive oxygen species ROS in cells. The cell permeable non-fluorescent H2DCFDA is cleaved by cellular esterases and oxidation, and converted to the highly fluorescent 2,7-dichlorofluorescein. H2DCFDA might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Peroxynitrite is an efficient mediator of this oxidation and neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH. This probe is widely used to monitoring cellular redox processes. Used as a component/substrate of the 2,7-dichlorofluorescein diacetate DCFH-DA assay to quantitate reactive oxygen species ROS. Can detect reactive oxygen species in live cells. Spectral data lambdaEx=504nm/lambdaEm=529nm.
Medchemexpress LLC Sincalide (ammonium) | 70706-98-8 | 99.2% | 1160.30 | 10 MG
Sincalide ammonium is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. It is a major bioactive segment of CCK that retains most of its biological activities. CCK-8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders, increasing bile secretion, causing gallbladder contraction, and relaxing the sphincter of Oddi for bile drainage into the duodenum.
- Significant inhibitory effect on myocardial fibrosis in noninfarcted areas
- Positive role in fighting inflammation, apoptosis, and collagen deposition
- Protects H9c2 cardiomyoblasts from Ang II‐induced apoptosis
- Alleviates fibrosis in noninfarcted regions
- Delays left ventricular remodeling and the progress of heart failure in a MI rat model
Medchemexpress LLC Sonlicromanol | 1541170-75-5 | 99.8% | 10 MG
Sonlicromanol is an orally active reactive oxygen species (ROS) modulator used for mitochondrial disease research. It is provided as a high-purity research reagent with good solubility in DMSO.
- Orally active ROS modulator suitable for mitochondrial disease research.
- High purity, 99.75%.
- Molecular formula C19H28N2O3; molecular weight 332.44 g·mol⁻¹.
- Soluble in DMSO at approximately 25 mg/mL; sonication may be required.
- Packaged as 10 mg for laboratory research use.
Medchemexpress LLC CCT365623 hydrochloride | 2126136-98-7 | 98.1% | 443.99 | C18H18ClNO4S3 | 100MG
CCT365623 hydrochloride is a research-grade small molecule lysyl oxidase (LOX) inhibitor used in biochemical and cellular studies. It is supplied as a solid (white to yellow) with reported potency IC50 0.89 μM against LOX. Analytical purity is 98.07%, molecular weight 443.99, and formula C18H18ClNO4S3. The compound is highly soluble in DMSO (250 mg/mL) and is hygroscopic in solution; store sealed and away from moisture, with solvent storage recommended at -80°C (up to 6 months) or -20°C (up to 1 month).
- Potent LOX inhibition with reported IC50 0.89 μM.
- High analytical purity of 98.07%.
- Molecular weight 443.99.
- Chemical formula C18H18ClNO4S3.
- Soluble in DMSO at 250 mg/mL; ultrasonic aid may be required.
- Solid, white to yellow; hygroscopic in DMSO.
- Store sealed away from moisture; solvent storage -80°C (6 months).
![Medchemexpress LLC N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alanineamide | 1233229-75-8 | 99.4% | 352.43 g/mol | C20H24N4O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221119.png-250.jpg)
Medchemexpress LLC N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alanineamide | 1233229-75-8 | 99.4% | 352.43 g/mol | C20H24N4O2 | 5 MG
Bliretrigine is a research-stage sodium channel blocker supplied for laboratory studies of pain and neuronal function. It is provided in high-purity solid and solution formats for preclinical experiments and is intended for research use only, not for human therapeutic use.
- Sodium channel blocker with reported analgesic activity.
- High purity suitable for research applications (99.4%).
- Available as powder and as a DMSO solution.
- Stable when stored under recommended conditions for powder and solutions.
- Intended for research use only; not for human use.