Furans
Apexbio Technology LLC PYR-41,10mg CAS# 418805-02-4
Ubiquitylation is catalyzed by the sequential action of ubiquitinactivating enzyme (E1), a ubiquitin-conjugating enzyme (E2) and a ubiquitin protein ligase (E3). Ubiquitylation is essential to numerous cellular and developmental processes, including protein quality control, growth, apoptosis, antigen presentation, DNA repair, and signal transduction. PYR-41, 4[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester, is a selective inhibitor of Ubiquitin-Activating Enzyme (E1).In vitro: In addition to blocking ubiquitylation, PYR-41 was found to increase total sumoylation in cells. PYR-41 could attenuate cytokine-mediated nuclear factor-KBactivation. This correlated with inhibition of nonproteasomal ubiquitylation of TRAF6, which is important to IKBkinase activation. Other sizes are also available. Please inqury us for quote.
eMolecules 3-ETHYNYLTETRAHYDRO-2H-PYRAN | 1260667-24-0 | MFCD18250569 | 1g
AstaTech | 3-ETHYNYLTETRAHYDRO-2H-PYRAN | 1g | 391060138 | P12240 | 95.000 | 1260667-24-0 | MFCD18250569 | 110.156 | C7H10O
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Medchemexpress LLC Dantrolene | 7261-97-4 | MFCD00867709 | 98.4% | 314.25 g/mol | C14H10N4O5 | 500MG
Dantrolene is a small-molecule ryanodine receptor antagonist used as a direct-acting skeletal muscle relaxant in research. It is supplied as a solid powder with a reported purity of 98.38% and is offered in multiple pack sizes, including a 500 mg vial. Manufacturer documentation includes a datasheet, certificate of analysis, and safety data sheet to support experimental use and handling.
Medchemexpress LLC CX-6258 (hydrochloride) | 1353859-00-3 | 99.0% | 498.40 | 50 MG
CX-6258 hydrochloride is a potent and kinase-selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, causing dose-dependent inhibition of pro-survival proteins like Bad and 4E-BP1. In vitro studies show it diminishes ectopic NKX3.1 levels, while in vivo, it exhibits robust efficacy in Pim kinases driven tumor models, demonstrating significant tumor growth inhibition.
- Potent and kinase-selective pan-Pim kinases inhibitor.
- Inhibits phosphorylation of pro-survival proteins.
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells.
- Exhibits robust efficacy in Pim kinases driven tumor models in vivo.
- For research use only.
Medchemexpress LLC ATH686 | 853299-52-2 | 99.54% | 515.53 | 5 MG
ATH686 is a potent, selective, and ATP-competitive FLT3 inhibitor that targets mutant FLT3 protein kinase activity. It inhibits the proliferation of cells harboring FLT3 mutants by inducing apoptosis and cell cycle inhibition, also exhibiting antileukemic effects.
- Potently inhibits cell proliferation (IC50 around 0.001 μM) in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells
- Induces apoptosis
- Inhibits autophosphorylation of mutant FLT3
- Exhibits antileukemic effects
Medchemexpress LLC Nitrofurantoin (Standard) | 67-20-9 | 99.7% | C8H6N4O5 | 50 MG
Nitrofurantoin (Standard) is the analytical standard of Nitrofurantoin. It is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent, primarily used for research and analytical applications. This antibiotic is suitable for the study of urinary tract infections (UTIs), including cystitis and kidney infections.
- Analytical standard for qualitative, quantitative, and methodological research
- Used in HPLC, GC, and MS experiments
- Potent and orally active broad-spectrum antimicrobial agent
- Acts as an antibiotic
- Suitable for studying urinary tract infections, including cystitis and kidney infections
Medchemexpress LLC Azimilide dihydrochloride | 149888-94-8 | 98.2% | 530.88 | 1 ML
Azimilide dihydrochloride is a class III antiarrhythmic agent that functions by blocking potassium channels in the heart. It is a dual blocker of IKs (IC50 = 2.6 μM) and IKr (IC50 = 1 μM), and also inhibits HERG channels, L-type calcium current (ICa), and sodium current (INa). This compound is used for the study of atrial fibrillation and ventricular fibrillation.
- Class III antiarrhythmic agent
- Blocks potassium channels in the heart
- Dual blocker of IKs and IKr
- Inhibits HERG channel
- Inhibits L-type calcium current (ICa) and sodium current (INa)
- Can be used for the study of atrial fibrillation and ventricular fibrillation
- Purity: 98.17%
Accela Chembio Inc Diethyl 3 | 4-furandicarboxylate | 5g | 30614-77-8 | MFCD00005349 | 95+% | D: 1.14 | Shelf Life: 1620 Days | Light Sensitive
Diethyl 3 | 4-furandicarboxylate | 5g | 30614-77-8 | MFCD00005349 | 95+% | D: 1.14 | Shelf Life: 1620 Days | Light Sensitive
Medchemexpress LLC Azimilide | 149908-53-2 | 99.0% | 457.95 | 5 MG
Azimilide is a class III antiarrhythmic agent that blocks potassium channels in the heart. It is a dual blocker of IKs and IKr potassium channels. It also blocks HERG channels, and inhibits L-type calcium current (ICa) and sodium current (INa). It can be used for the study of atrial fibrillation and ventricular fibrillation.
- Class III antiarrhythmic agent
- Dual blocker of IKs and IKr potassium channels
- Blocks HERG channels
- Inhibits L-type calcium current (ICa)
- Inhibits sodium current (INa)
- Can be used for the study of atrial fibrillation and ventricular fibrillation
- Significantly reduces the occurrence of ventricular tachycardia (VT) induced by electrical stimulation (PES) in dogs
- Prolongs the effective refractory period of the ventricle and the QTc interval
- Provides significant protection against ischemia-induced ventricular fibrillation and improves survival rates
Medchemexpress LLC 3-Furaldehyde | 498-60-2 | 99.94% | C5H4O2 | 5 G
3-Furaldehyde is a furan member and an aldehyde used in synthesizing the neoclerodane diterpene Salvinorin A. It is also an atmospheric pollutant from biomass burning, undergoing photoisomerization and photolysis under ultraviolet light. It is available as a colorless to light yellow liquid.
- Can be used in the synthesis of Salvinorin A
- Atmospheric pollutant derived from biomass burning
- Undergoes photoisomerization and photolysis reactions
- Research use only
eMolecules Medchem Express / CX-6258 (hydrochloride) / 5mg / 601586574 / HY-18095B / / 1353859-00-3 / MFCD28137787 / 498.400 / C26H25Cl2N3O3
Medchem Express / CX-6258 (hydrochloride) / 5mg / 601586574 / HY-18095B / / 1353859-00-3 / MFCD28137787 / 498.400 / C26H25Cl2N3O3
Medchemexpress LLC Pf-06456384 trihydrochloride | 1834610-75-1 | 99.4% | 829.18 g/mol | C35H35Cl3F3N7O3S2 | 5 MG
PF-06456384 trihydrochloride is a research-grade small-molecule trihydrochloride salt and a highly potent, selective NaV1.7 inhibitor (reported IC50 = 0.01 nM) provided for preclinical pharmacology and pain-model studies.
- High potency and selectivity toward NaV1.7 for target validation and pharmacology studies.
- Trihydrochloride salt form improves compound handling and solubility for assays.
- High purity (reported ~99.38%) suitable for research applications.
- Molecular weight 829.18 g/mol; white to off-white solid.
- Supplied in small research quantities for assay development and in vivo pilot studies.