Furans
Medchemexpress LLC Cobomarsen (MRG-106) | 1848257-52-2 | 4736.00 g/mol | C148H177N52O77P13S13 | 5 MG
Cobomarsen (MRG-106) is a locked nucleic acid-modified oligonucleotide inhibitor of microRNA-155 (miR-155) used in preclinical research to reduce cellular proliferation and survival by modulating multiple signaling pathways. The material is supplied as a solid research-grade compound and should be handled per the manufacturer's storage and handling guidance.
- Inhibits miR-155 to modulate JAK/STAT, MAPK/ERK, and PI3K/AKT signaling.
- Designed as an LNA/modified oligonucleotide for increased affinity and stability.
- Provided as a white to off-white solid suitable for laboratory use.
- CAS 1848257-52-2; molecular weight approximately 4736.00 g/mol.
- Intended for preclinical and mechanistic studies in hematologic and lymphoid disease models.
![Medchemexpress LLC 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydrocyclopenta[c]quinolin-8-yl]ethanone | 881639-98-1 | 99.8% | 412.28 g·mol⁻¹ | C21H18BrNO3 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239967.png-250.jpg)
Medchemexpress LLC 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydrocyclopenta[c]quinolin-8-yl]ethanone | 881639-98-1 | 99.8% | 412.28 g·mol⁻¹ | C21H18BrNO3 | 50 MG
G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 (G protein-coupled estrogen receptor) with a reported Ki of 11 nM. It is supplied as a research reagent with formula C21H18BrNO3, molecular weight 412.28 g·mol⁻¹, and high reported purity suitable for in vitro signaling studies.
- Selective GPR30 agonist (Ki = 11 nM).
- High purity (99.76%).
- Molecular formula C21H18BrNO3 and molecular weight 412.28 g·mol⁻¹.
- Soluble in DMSO for assay preparation.
- Intended for research use only; not for human use.
Medchemexpress LLC BMS-911172 50mg | 1644248-18-9 | 339.34 g/mol | C16H19F2N3O3 | 50 MG
BMS-911172 is a small-molecule, brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) supplied as a 50 mg solid for research use only. It was developed as a tool compound to validate AAK1 as a target for neuropathic pain; reported potency varies across sources.
- Inhibits AAK1 with reported IC50 in the low nanomolar range (reported values 12-35 nM).
- Brain-penetrant small molecule suitable for in vitro and in vivo studies.
- Supplied as a solid at 50 mg quantity.
- High supplier-reported purity (typically ≥99%).
- Provided for research use only; not for human therapeutic use.
Medchemexpress LLC Epoxiconazole | 133855-98-8 | 99.0% | 25 MG
Epoxiconazole is a triazole-class fungicide and demethylation inhibitor of ergosterol biosynthesis, supplied as a high-purity analytical reagent for laboratory research.
- Triazole fungicide and ergosterol biosynthesis inhibitor.
- High purity, 99.0% (as supplied).
- Chemical formula C17H13ClFN3O; molecular weight 329.76 g/mol.
- Suitable as a reference standard or reagent for biochemical assays.
- Available as a small-scale solid dose for analytical testing.
- Includes datasheet and safety data sheet for handling and storage guidance.
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.89% | 610.01 | 50 MG
JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. It increases H3K4me3 and can be used for the research of multiple myeloma.
- Increases global H3K4me3 levels in cells.
- Inhibits cell growth in a dose- and time-dependent manner (IC50=0.42 μM).
- Induces G1 cell-cycle arrest.
- Exhibits anti-multiple myeloma activity in vivo.
- Leads to increased H3K4me3 levels and reduced MYC immuno-staining.
- Significantly reduces tumor burden in mouse models.
Medchemexpress LLC Furazolidone | 67-45-8 | MFCD00010550 | 1 ML
Furazolidone is a monoamine oxidase (MAO) inhibitor that possesses antiproliferative, apoptosis-inducing, and differentiation-promoting characteristics. It has the potential to inhibit leukemia fusion protein-mediated bone marrow transformation by increasing the stability of the tumor suppressor protein p53. Furthermore, Furazolidone demonstrates anti-leukemic activity in acute myeloid leukemia (AML) cell lines and is suitable for anti-AML research.
- Monoamine oxidase (MAO) inhibitor.
- Exhibits antiproliferative activity.
- Induces apoptosis.
- Promotes differentiation.
- May inhibit leukemia fusion protein-mediated bone marrow transformation.
- Upregulates the stability of tumor suppressor protein p53.
- Shows anti-leukemic activity in acute myeloid leukemia (AML) cell lines.
- Can be used for anti-AML research.
Medchemexpress LLC PF-06456384 trihydrochloride | 1834610-75-1 | MFCD31697702 | 99.4% | 829.18 | C35H35Cl3F3N7O3S2 | 10 MG
PF-06456384 trihydrochloride is a research-grade small-molecule inhibitor selective for the voltage-gated sodium channel NaV1.7. It is reported to have extremely high potency (IC50 = 0.01 nM) and is supplied at high purity for use in in vitro and in vivo pain-model research.
- Highly potent NaV1.7 inhibitor (IC50 = 0.01 nM).
- High purity suitable for research applications (>99%).
- Molecular weight 829.18 and formula C35H35Cl3F3N7O3S2.
- Provided as the trihydrochloride salt for enhanced stability and handling.
- Intended for laboratory research use only.
Medchemexpress LLC 2-pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 10MG
DMA-135 hydrochloride is the hydrochloride salt of a small-molecule ligand that targets the enterovirus 71 (EV71) SLII RNA domain and inhibits EV71 IRES-dependent translation and replication; it has a reported KD of ~520 nM and shows no significant toxicity in cell-based studies. Provided as a light-yellow solid with high purity for biochemical and cellular research.
- Binds EV71 SLII RNA with moderate affinity.
- Inhibits IRES-dependent translation and viral replication in vitro.
- High purity suitable for biochemical and cell-based assays.
- Available as solid and as 10 mM solution in DMSO.
- Light yellow solid appearance for easy visual inspection.
- Stable when stored sealed; follow recommended temperature guidelines.
Medchemexpress LLC Ry796 | 1393441-53-6 | 98.6% | 5 MG
RY796 is a potent, selective inhibitor of voltage-gated potassium (KV2) channels used in preclinical research; it shows analgesic activity and inhibits KV2.1 and KV2.2 with IC50 values in the submicromolar range.
- Selective KV2 channel inhibitor (IC50: 0.25 μM for KV2.1, 0.09 μM for KV2.2).
- Demonstrates analgesic activity in preclinical models.
- High research-grade purity (98.6%).
- Soluble in DMSO at 100 mg/mL; in vivo formulations documented.
- Stable as a powder at standard low-temperature storage conditions.
Medchemexpress LLC 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one | 34320-83-7 | 99.7% | 281.3 | C15H11N3O3 | 100 MG
TCS PrP Inhibitor 13 is a research small molecule that inhibits cellular prion protein (PrPC) and reduces accumulation of protease-resistant prion protein (PrP-res). It is employed in cellular studies to evaluate antiprion activity and related effects on cell viability and apoptosis.
- Potent inhibitor with an IC50 of about 3 nM in ScN2a and F3 cells.
- Reported to induce apoptosis in Schwannoma cells.
- High purity (99.72%) suitable for research applications.
- Supplied as a solid powder and as a DMSO solution (10 mM).
- Stable when stored as a powder at -20 °C (up to 3 years) or 4 °C (up to 2 years).
- In-solution storage: -80 °C (up to 6 months) or -20 °C (up to 1 month).
Medchemexpress LLC Eprazinone dihydrochloride | 10402-53-6 | 99.05% | 50 MG
Eprazinone dihydrochloride is a mucolytic, secretolytic, antitussic, and bronchial antispasmodic agent. It functions as a neurokinin 1 receptor (NK1R) ligand and shows potential for treating chronic bronchitis by improving pulmonary function and arterial partial pressure of oxygen. It is for research use only.
- Functions as a neurokinin 1 receptor (NK1R) ligand
- Potential for treating chronic bronchitis
- Improves pulmonary function and arterial partial pressure of oxygen
- Specifically displaces binding to the NK1R
- May contribute to mucolytic activity through NK1R blockade
- Increases total and individual phospholipid levels at higher doses in animal studies
- Decreases total neutral lipids at higher doses in animal studies
- Produces a dose-dependent decrease in short-circuit current (Isc) in airway epithelial studies
Medchemexpress LLC Inx-sm-56 | 2734878-18-1 | 99.5% | 576.70 | C32H36N2O6S | 1 MG
INX-SM-56 is a cytotoxin used as an antibody-drug conjugate (ADC) payload for the synthesis of anti-VISTA antibody conjugates. It is supplied as a white-to-yellow solid with high analytical purity and is intended for research use.
- Cytotoxin for antibody-drug conjugate synthesis.
- High purity: 99.47% (analytical).
- Molecular weight: 576.70; formula: C32H36N2O6S.
- CAS number: 2734878-18-1.
- Available in small research sizes such as 1 mg and 5 mg.
- Storage: 4°C, sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Evixapodlin | 2374856-75-2 | 98.1% | C34H36Cl2N8O4 | 10MG
Evixapodlin is an orally bioavailable small-molecule inhibitor of programmed death-ligand 1 (PD-L1) used in research to modulate PD-1/PD-L1 protein-protein interactions. It has demonstrated potent activity in preclinical assays and has been evaluated in early clinical studies for advanced solid tumors.
- Chemical name: Evixapodlin.
- CAS number: 2374856-75-2.
- Molecular formula: C34H36Cl2N8O4.
- Molecular weight: 691.61.
- Reported IC50: 0.213 nM (PD-1/PD-L1 protein-protein interaction).
- Purity: 98.1% (HPLC).
- Physical form: powder for research use.
- Typical use: reagent for PD-1/PD-L1 pathway and oncology research.
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.9% | C27H43Cl3N4O5 | 10MG
JQKD82 trihydrochloride is a cell-permeable, selective inhibitor of lysine demethylase KDM5 (JARID1) used in epigenetic research. It increases histone H3 lysine 4 trimethylation (H3K4me3) and is applied in studies of multiple myeloma and KDM5-mediated regulation.
- Selective KDM5 inhibitor.
- Cell-permeable small molecule for intracellular studies.
- Increases H3K4me3 levels in treated cells.
- Supplied as the trihydrochloride salt for enhanced stability.
- High purity suitable for research use (99.9%).
- Available in multiple milligram pack sizes for assay flexibility.
eMolecules 5638-76-6 | 2-(2-Methylaminoethyl)pyridine | Combi-Blocks | MFCD00006362 | 136.198 | C8H12N2 | 97.000 | CNCCc1ccccn1 | 25g | 457916687
2-(2-Methylaminoethyl)pyridine | Combi-Blocks | 5638-76-6 | MFCD00006362 | 136.198 | C8H12N2 | 97.000 | CNCCc1ccccn1 | 25g | 457916687