Lactams
eMolecules 1950635-17-2 | Thalidomide-5-(C6-amine) | Broadpharm400.435 | C20H24N4O5 | 98.000 | NCCCCCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699636
Thalidomide-5-(C6-amine) | Broadpharm | 1950635-17-2400.435 | C20H24N4O5 | 98.000 | NCCCCCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699636
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | MFCD34706062 | 98.6% | 571.58 g/mol | C29H29N7O6 | 5 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide developed as an E3 ligase ligand and click-chemistry reagent. It is designed to undergo inverse electron-demand Diels-Alder (iEDDA) reactions with strained alkenes and has demonstrated binding activity to BRD4 in biochemical assays.
- Tetrazine functional group for rapid iEDDA click reactions with TCO-modified partners.
- Reported BRD4 binding (IC50: 46.25 μM for BRD4-1; 62.55 μM for BRD4-2).
- High purity suitable for research applications (98.6%).
- Solid, pink to red appearance for easy handling.
- Soluble in DMSO (~50 mg/mL), facilitating stock solution preparation.
- Storage conditions provided to support stability in powder and solution.
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Thalidomide-4-o-c12-nh2 hydrochloride | 95.6% | 494.02 | 25 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Can be linked to a protein ligand via a linker to form PROTACs
- Target: Cereblon
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 100 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
eMolecules 50607-30-2 | 2,4-Piperidinedione | Combi-Blocks | MFCD08704814 | 113.116 | C5H7NO2 | 98.000 | O=C1CCNC(=O)C1 | 25g | 205391986
2,4-Piperidinedione | Combi-Blocks | 50607-30-2 | MFCD08704814 | 113.116 | C5H7NO2 | 98.000 | O=C1CCNC(=O)C1 | 25g | 205391986
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 1 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. Thalidomide targets cereblon (CRBN), a protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The product appears as an off-white to gray solid.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to the ligand for IRAK4 protein to form PROTAC IRAK4 degrader-1
- Targets cereblon (CRBN), part of the CUL4-RBX1-DDB1 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 99.96% | 258.23 | 100 MG
Thalidomide (Standard) is an analytical standard intended for research and analytical applications. It inhibits cereblon (CRBN), part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, and possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. It can also act as a molecular glue to potentiate substrate. This analytical standard is suitable for various assays and commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Inhibits cereblon (CRBN)
- Possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties
- Can act as a molecular glue to potentiate substrate
- Suitable for assays
- Used in HPLC, GC, and MS experiments
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 100 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide used in bioorthogonal click-chemistry and as an E3 ligase ligand for biochemical research. It contains a reactive tetrazine group for rapid conjugation via inverse electron demand Diels-Alder reactions and has been characterized for binding to BRD4.
- Tetrazine moiety enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Functions as an E3 ligase ligand for targeted protein interaction studies.
- Documented binding affinity to BRD4 in biochemical assays.
- High purity suitable for research applications.
- Available as a solid and as a 10 mM solution in DMSO for experimental flexibility.
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | MFCD30290642 | 99.9% | 272.26 g·mol-1 | C14H12N2O4 | 5 MG
Thalidomide-5-methyl is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase subunit in chemical biology and targeted protein degradation applications. It is provided as a research-grade small molecule suitable for use as a CRBN-binding moiety in PROTAC synthesis.
- Cereblon (CRBN) ligand for recruiting E3 ligase in PROTAC design.
- High purity suitable for research applications (99.87%).
- Molecular formula C14H12N2O4 and molecular weight 272.26 g·mol-1.
- Supplied in milligram-scale quantities for synthesis and assay development.
- Useful as a modular CRBN-binding building block in chemical biology experiments.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | 381.81 | C17H20ClN3O5 | 5 MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC research. It couples a thalidomide-derived cereblon ligand to a four-carbon alkyl linker terminating in a primary amine, enabling conjugation to target-binding moieties. The material is intended for laboratory research use only.
- High purity (99.35%).
- Hydrochloride salt form for handling and stability.
- Molecular weight 381.81.
- Molecular formula C17H20ClN3O5.
- Available in small research quantities (5 mg and up).
- Intended for use in PROTAC design and cereblon-based degrader development.
Medchemexpress LLC Thalidomide-5-PEG7-NH2 hydrochloride | 618.07 g/mol | C27H40ClN3O11 | 10 MG
Thalidomide-5-PEG7-NH2 hydrochloride is a thalidomide-derived cereblon ligand with a PEG7 spacer provided as the hydrochloride salt. It is designed for use as an E3 ligase ligand in PROTAC and ligand-linker conjugate synthesis and is supplied as a solid for research applications.
- Thalidomide-derived cereblon ligand for recruitment of CRBN.
- PEG7 spacer offers a flexible linker for conjugation to target ligands.
- Provided as the hydrochloride salt to aid handling and solubility.
- White to off-white solid physical form.
- Molecular formula C27H40ClN3O11 and molecular weight 618.07 g/mol.
- Store sealed at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month.
- Available in small mg quantities for laboratory research use.
Medchemexpress LLC Tz-thalidomide | 2087490-42-2 | 98.6% | 571.58 | C29H29N7O6 | 10 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide used in degrader and click-chemistry research. It serves as an E3 ligase ligand and contains a tetrazine group capable of undergoing inverse electron-demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners. Reported biochemical data indicate binding affinity for BRD4. Typical purity is 98.6% and the compound is supplied as a solid and as a 10 mM solution in DMSO.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 | C13H9FN2O4 | 1 ML
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in targeted protein degradation (PROTAC) research and related chemical biology applications. It is supplied as both solid material and pre-formulated DMSO solutions to facilitate linker conjugation and assay use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Cas number: 835616-61-0.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- Purity reported at 99.96% (analytical).
- Available as 10 mM solution in DMSO (1 mL) and as solid in multiple package sizes.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.