Lactams
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 50 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- Utilized in PROTAC technology.
- Exploits intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Targets Cereblon.
- For research use only.
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 25 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a cereblon (CRBN) ligand in the synthesis of PROTAC degraders and other bifunctional molecules. It is supplied as an off-white to gray solid with high purity for research use.
- High purity: 98.0%.
- Molecular weight: 335.74 g/mol.
- Molecular formula: C15H14ClN3O4.
- CAS number: 2616553-35-4.
- Physical form: off-white to gray solid.
- Storage: store dry and keep cool; in solution store at -80°C (2 years) or -20°C (1 year).
- Applications: used as an E3 ligase ligand for PROTAC synthesis.
Medchemexpress LLC (S)-thalidomide-4-oh | 2357105-36-1 | 98.0% | 274.23 g/mol | C13H10N2O5 | 50 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-derived cereblon ligand used in chemical biology and medicinal chemistry. Supplied as a solid research reagent, it is commonly used to recruit CRBN in PROTAC design and as a building block for medicinal chemistry.
- S-enantiomer of thalidomide-4-OH for stereospecific studies.
- Cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable building block for PROTAC synthesis and linker chemistry.
- Off-white to light yellow solid; typical pack size 50 mg.
- Reported purity 98.0% and molecular weight 274.23 g/mol.
eMolecules Thalidomide-5-(PEG4-acid) | Broadpharm |549.533 | C25H31N3O11 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699648
Thalidomide-5-(PEG4-acid) | Broadpharm |549.533 | C25H31N3O11 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699648
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 100 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-O-C7-NH2 hydrochloride | 98.1% | 423.89 g/mol | C20H26ClN3O5 | 10 MG
Thalidomide-5-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand supplied as the hydrochloride salt for use in chemical biology and targeted protein degradation research. It is designed to be connected to target ligands via a linker to build PROTACs and other CRBN-recruiting constructs, and includes storage recommendations to preserve compound integrity.
- Facilitates cereblon (CRBN) recruitment for targeted degradation studies.
- Hydrochloride salt form for improved handling and stability.
- Compatible with linker conjugation to form PROTAC molecules.
- Provided with documented molecular and storage data to support experimental planning.
- Suitable for research applications requiring characterized E3 ligase ligands.
Medchemexpress LLC Thalidomide-O-amido-C3-PEG3-C1-NH2 | 1799711-29-7 | 99.1% | 648.58 g/mol | C27H35F3N4O11 | 5 MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a thalidomide-derived cereblon E3 ligase ligand conjugated to a three-unit PEG linker and a short C3 spacer terminating in an amine. Supplied for research use, it is intended as a linker-ligand building block for PROTAC design and related chemical biology applications.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker and C3 spacer terminating in an amine for conjugation.
- High purity suitable for research applications (~99.1%).
- Available in small pack sizes for discovery work (mg scale).
- Store sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only, not for human use.
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 50 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker used in PROTAC technology
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 | C15H12N2O7 | 25 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiter in PROTAC and chemical biology research. It is supplied as a solid research reagent with high purity and characterized molecular properties for use in biochemical and cellular assays.
- High purity: 99.85%.
- Molecular formula: C15H12N2O7.
- Molecular weight: 332.27 g/mol.
- Appearance: solid, white to off-white.
- Available package sizes include 25 G for bulk research use.
- Intended use: cereblon recruitment and PROTAC design in research applications.